Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment
Although cystic fibrosis (CF) is an irreversible genetic disease, advances in treatment have increased the life expectancy of CF patients. Upper airway involvement, which is mainly due to pathological changes in the paranasal sinuses, is prevalent in CF patients, although many are only mildly sympto...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pneumologia e Tisiologia
2015-02-01
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| Series: | Jornal Brasileiro de Pneumologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/jbpneu/v41n1/pt_1806-3713-jbpneu-41-01-00065.pdf |
| _version_ | 1819003242979262464 |
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| author | Suzie Hyeona Kang Paulo de Tarso Roth Dalcin Otavio Bejzman Piltcher Raphaella de Oliveira Migliavacca |
| author_facet | Suzie Hyeona Kang Paulo de Tarso Roth Dalcin Otavio Bejzman Piltcher Raphaella de Oliveira Migliavacca |
| author_sort | Suzie Hyeona Kang |
| collection | DOAJ |
| description | Although cystic fibrosis (CF) is an irreversible genetic disease, advances in treatment have increased the life expectancy of CF patients. Upper airway involvement, which is mainly due to pathological changes in the paranasal sinuses, is prevalent in CF patients, although many are only mildly symptomatic (with few symptoms). The objective of this literature review was to discuss the pathophysiology and current therapeutic management of chronic rhinosinusitis (CRS) in CF patients. The review was based on current evidence, which was classified in accordance with the Oxford Centre for Evidence-Based Medicine criteria. When symptomatic, CRS with nasal polyps can affect quality of life and can lead to pulmonary exacerbations, given that the paranasal sinuses can be colonized with pathogenic bacteria, especially Pseudomonas aeruginosa. Infection with P. aeruginosa plays a crucial role in morbidity and mortality after lung transplantation in CF patients. Although clinical treatment of the upper airways is recommended as initial management, this recommendation is often extrapolated from studies of CRS in the general population. When sinonasal disease is refractory to noninvasive therapy, surgery is indicated. Further studies are needed in order to gain a better understanding of upper airway involvement and improve the management of CRS in CF patients, with the objective of preserving lung function and avoiding unnecessary invasive procedures. |
| first_indexed | 2024-12-20T23:17:54Z |
| format | Article |
| id | doaj.art-ab7f92f187e5423a9a7fdc7e5a9df234 |
| institution | Directory Open Access Journal |
| issn | 1806-3756 |
| language | English |
| last_indexed | 2024-12-20T23:17:54Z |
| publishDate | 2015-02-01 |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj.art-ab7f92f187e5423a9a7fdc7e5a9df2342022-12-21T19:23:35ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-37562015-02-01411657610.1590/s1806-37132015000100009Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatmentSuzie Hyeona KangPaulo de Tarso Roth DalcinOtavio Bejzman PiltcherRaphaella de Oliveira MigliavaccaAlthough cystic fibrosis (CF) is an irreversible genetic disease, advances in treatment have increased the life expectancy of CF patients. Upper airway involvement, which is mainly due to pathological changes in the paranasal sinuses, is prevalent in CF patients, although many are only mildly symptomatic (with few symptoms). The objective of this literature review was to discuss the pathophysiology and current therapeutic management of chronic rhinosinusitis (CRS) in CF patients. The review was based on current evidence, which was classified in accordance with the Oxford Centre for Evidence-Based Medicine criteria. When symptomatic, CRS with nasal polyps can affect quality of life and can lead to pulmonary exacerbations, given that the paranasal sinuses can be colonized with pathogenic bacteria, especially Pseudomonas aeruginosa. Infection with P. aeruginosa plays a crucial role in morbidity and mortality after lung transplantation in CF patients. Although clinical treatment of the upper airways is recommended as initial management, this recommendation is often extrapolated from studies of CRS in the general population. When sinonasal disease is refractory to noninvasive therapy, surgery is indicated. Further studies are needed in order to gain a better understanding of upper airway involvement and improve the management of CRS in CF patients, with the objective of preserving lung function and avoiding unnecessary invasive procedures.http://www.scielo.br/pdf/jbpneu/v41n1/pt_1806-3713-jbpneu-41-01-00065.pdfNose diseasesCystic fibrosisNasal polypsParanasal sinusesSinusitis |
| spellingShingle | Suzie Hyeona Kang Paulo de Tarso Roth Dalcin Otavio Bejzman Piltcher Raphaella de Oliveira Migliavacca Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment Jornal Brasileiro de Pneumologia Nose diseases Cystic fibrosis Nasal polyps Paranasal sinuses Sinusitis |
| title | Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment |
| title_full | Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment |
| title_fullStr | Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment |
| title_full_unstemmed | Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment |
| title_short | Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment |
| title_sort | chronic rhinosinusitis and nasal polyposis in cystic fibrosis update on diagnosis and treatment |
| topic | Nose diseases Cystic fibrosis Nasal polyps Paranasal sinuses Sinusitis |
| url | http://www.scielo.br/pdf/jbpneu/v41n1/pt_1806-3713-jbpneu-41-01-00065.pdf |
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