Pharmacological aspects of acute treatment glycoside intoxication
Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases. Moreover, interest in this group of drugs is only increasing with the discovery...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Private institution educational organization of higher education "Medical University "ReaViz"
2021-08-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| Subjects: | |
| Online Access: | https://vestnik.reaviz.ru/jour/article/view/253 |
| _version_ | 1797695100558508032 |
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| author | M. I. Sperling E. G. Kruchinin A. S. Gogolevsky |
| author_facet | M. I. Sperling E. G. Kruchinin A. S. Gogolevsky |
| author_sort | M. I. Sperling |
| collection | DOAJ |
| description | Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases. Moreover, interest in this group of drugs is only increasing with the discovery of new pharmacological effects, such as antitumor and antiviral. However, despite many years of experience, the issue of managing patients with symptoms of both acute and chronic poisoning with cardiac glycosides remains one of the leading ones. The literature review provides a brief historical outline of cardiac glycoside poisoning and comprehensively describes the pharmacokinetics and pharmacodynamics of this group of drugs. The clinical picture of intoxication is described. We analyzed modern ideas and limitations of using antidote therapy such as digoxin immune Fab-antibody fragments, as well as the features of pathogenetic and symptomatic treatment of patients with acute glycoside poisoning. |
| first_indexed | 2024-03-12T03:06:22Z |
| format | Article |
| id | doaj.art-ab80095ab12e45aa82853e6a4f9f26e1 |
| institution | Directory Open Access Journal |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| last_indexed | 2024-03-12T03:06:22Z |
| publishDate | 2021-08-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj.art-ab80095ab12e45aa82853e6a4f9f26e12023-09-03T14:32:45ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792021-08-010412013410.20340/vmi-rvz.2021.4.CLIN.1206Pharmacological aspects of acute treatment glycoside intoxicationM. I. Sperling0E. G. Kruchinin1A. S. Gogolevsky2Военно-медицинская академия им. С.М. КироваГосударственный научно-исследовательский испытательный институт военной медициныГосударственный научно-исследовательский испытательный институт военной медициныDespite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases. Moreover, interest in this group of drugs is only increasing with the discovery of new pharmacological effects, such as antitumor and antiviral. However, despite many years of experience, the issue of managing patients with symptoms of both acute and chronic poisoning with cardiac glycosides remains one of the leading ones. The literature review provides a brief historical outline of cardiac glycoside poisoning and comprehensively describes the pharmacokinetics and pharmacodynamics of this group of drugs. The clinical picture of intoxication is described. We analyzed modern ideas and limitations of using antidote therapy such as digoxin immune Fab-antibody fragments, as well as the features of pathogenetic and symptomatic treatment of patients with acute glycoside poisoning.https://vestnik.reaviz.ru/jour/article/view/253сердечные гликозидыгликозидная интоксикацияfab-фрагменты антител к дигоксину |
| spellingShingle | M. I. Sperling E. G. Kruchinin A. S. Gogolevsky Pharmacological aspects of acute treatment glycoside intoxication Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье сердечные гликозиды гликозидная интоксикация fab-фрагменты антител к дигоксину |
| title | Pharmacological aspects of acute treatment glycoside intoxication |
| title_full | Pharmacological aspects of acute treatment glycoside intoxication |
| title_fullStr | Pharmacological aspects of acute treatment glycoside intoxication |
| title_full_unstemmed | Pharmacological aspects of acute treatment glycoside intoxication |
| title_short | Pharmacological aspects of acute treatment glycoside intoxication |
| title_sort | pharmacological aspects of acute treatment glycoside intoxication |
| topic | сердечные гликозиды гликозидная интоксикация fab-фрагменты антител к дигоксину |
| url | https://vestnik.reaviz.ru/jour/article/view/253 |
| work_keys_str_mv | AT misperling pharmacologicalaspectsofacutetreatmentglycosideintoxication AT egkruchinin pharmacologicalaspectsofacutetreatmentglycosideintoxication AT asgogolevsky pharmacologicalaspectsofacutetreatmentglycosideintoxication |