Differential Effects of Domoic Acid and E. coli Lipopolysaccharide on Tumor Necrosis Factor-α, Transforming Growth Factor-β1 and Matrix Metalloproteinase-9 Release by Rat Neonatal Microglia: Evaluation of the Direct Activation Hypothesis

Differential Effects of Domoic Acid and E. coli Lipopolysaccharide on Tumor Necrosis Factor-α, Transforming Growth Factor-β1 and Matrix Metalloproteinase-9 Release by Rat Neonatal Microglia: Evaluation of the Direct Activation Hypothesis

The excitatory amino acid domoic acid is the causative agent of amnesic shellfish poisoning in humans. The in vitro effects of domoic acid on rat neonatal brain microglia were compared with E. coli lipopolysaccharide (LPS), a known activator of microglia mediator release over a 4 to 24 hour observat...

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Bibliographic Details
Main Authors: Sarath P. Gunasekera, Anne M. Romanic, Peer B. Jacobson, Michael J. Fay, Mary Hall, Renee Peksa, Marcio Guzman, Alejandro M. S. Mayer
Format: Article
Language:English
Published: MDPI AG 2007-09-01
Series:Marine Drugs
Subjects:
domoic acid
microglia
tumor necrosis factor-α
TNF-α
transforming growth factor β1
TGF-β1
matrix metalloproteinase-9
LPS
lipopolysaccharide
excitotoxic
endotoxin.
Online Access:http://www.mdpi.com/1660-3397/5/3/113/

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