Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough during the Induction of Anesthesia in Children under General Anesthesia
Background: One of the main adverse effects of fentanyl, as the most commonly used anesthetic drug in children, is coughing. Several medications have been used to reduce this complication. In this study, the effect of ketamine and lidocaine on cough reduction after fentanyl injection was investigate...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2019-04-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/10973 |
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| author | Amir Shafa Mohamadreza Habibzadeh Negin Goodarzi |
| author_facet | Amir Shafa Mohamadreza Habibzadeh Negin Goodarzi |
| author_sort | Amir Shafa |
| collection | DOAJ |
| description | Background: One of the main adverse effects of fentanyl, as the most commonly used anesthetic drug in children, is coughing. Several medications have been used to reduce this complication. In this study, the effect of ketamine and lidocaine on cough reduction after fentanyl injection was investigated.
Methods: This was a randomized clinical trial study on 120 children under general anesthesia aged 6 months to 2 years, with class I and II based on the American Society of Anesthesiologists (ASA) scoring. Patients were divided into 3 equal groups treated with lidocaine (1 mg/kg), ketamine (0.15 mg/kg), and normal saline (control group). The incidence and severity of cough, heart rate, mean arterial pressure, and oxygen saturation were compared between the 3 groups.
Findings: The incidence (P = 0.03) and severity (P = 0.03) of cough in control group was significantly higher than two other groups of ketamine and lidocaine.
Conclusion: Based on our findings, use of ketamine and/or lidocaine significantly reduces the incidence and severity of coughing following intravenous fentanyl administration under general anesthesia. |
| first_indexed | 2024-03-12T07:13:31Z |
| format | Article |
| id | doaj.art-ab83150fcf264fc7be410f73dd85b1d3 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T07:13:31Z |
| publishDate | 2019-04-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-ab83150fcf264fc7be410f73dd85b1d32023-09-02T22:57:13ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2019-04-01375161081133317Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough during the Induction of Anesthesia in Children under General AnesthesiaAmir Shafa0Mohamadreza Habibzadeh1Negin Goodarzi2Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: One of the main adverse effects of fentanyl, as the most commonly used anesthetic drug in children, is coughing. Several medications have been used to reduce this complication. In this study, the effect of ketamine and lidocaine on cough reduction after fentanyl injection was investigated. Methods: This was a randomized clinical trial study on 120 children under general anesthesia aged 6 months to 2 years, with class I and II based on the American Society of Anesthesiologists (ASA) scoring. Patients were divided into 3 equal groups treated with lidocaine (1 mg/kg), ketamine (0.15 mg/kg), and normal saline (control group). The incidence and severity of cough, heart rate, mean arterial pressure, and oxygen saturation were compared between the 3 groups. Findings: The incidence (P = 0.03) and severity (P = 0.03) of cough in control group was significantly higher than two other groups of ketamine and lidocaine. Conclusion: Based on our findings, use of ketamine and/or lidocaine significantly reduces the incidence and severity of coughing following intravenous fentanyl administration under general anesthesia.http://jims.mui.ac.ir/index.php/jims/article/view/10973FentanylKetamineLidocaineCoughAnesthesiaChild |
| spellingShingle | Amir Shafa Mohamadreza Habibzadeh Negin Goodarzi Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough during the Induction of Anesthesia in Children under General Anesthesia مجله دانشکده پزشکی اصفهان Fentanyl Ketamine Lidocaine Cough Anesthesia Child |
| title | Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough during the Induction of Anesthesia in Children under General Anesthesia |
| title_full | Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough during the Induction of Anesthesia in Children under General Anesthesia |
| title_fullStr | Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough during the Induction of Anesthesia in Children under General Anesthesia |
| title_full_unstemmed | Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough during the Induction of Anesthesia in Children under General Anesthesia |
| title_short | Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough during the Induction of Anesthesia in Children under General Anesthesia |
| title_sort | comparison of the effect of lidocaine and ketamine on prevention of fentanyl induced cough during the induction of anesthesia in children under general anesthesia |
| topic | Fentanyl Ketamine Lidocaine Cough Anesthesia Child |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/10973 |
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