Kalpra: A kernel approach for longitudinal pathway regression analysis integrating network information with an application to the longitudinal PsyCourse Study

Kalpra: A kernel approach for longitudinal pathway regression analysis integrating network information with an application to the longitudinal PsyCourse Study

A popular approach to reduce the high dimensionality resulting from genome-wide association studies is to analyze a whole pathway in a single test for association with a phenotype. Kernel machine regression (KMR) is a highly flexible pathway analysis approach. Initially, KMR was developed to analyze...

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Bibliographic Details
Main Authors: Bernadette Wendel, Markus Heidenreich, Monika Budde, Maria Heilbronner, Mojtaba Oraki Kohshour, Sergi Papiol, Peter Falkai, Thomas G. Schulze, Urs Heilbronner, Heike Bickeböller
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Genetics
Subjects:
pathway analysis
kernel machine regression
longitudinal data
network
PsyCourse Study
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1015885/full

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