Pharmacological inhibition of LSD1 suppresses growth of hepatocellular carcinoma by inducing GADD45B

Pharmacological inhibition of LSD1 suppresses growth of hepatocellular carcinoma by inducing GADD45B

Abstract Lysine‐specific histone demethylase 1 (LSD1) is an attractive target for malignancies therapy. Nevertheless, its role in hepatocellular carcinoma (HCC) progression and the potential of its inhibitor in HCC therapy remains unclear. Here, we show that LSD1 overexpression in human HCC tissues...

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Bibliographic Details
Main Authors: Na Sang, Xi Zhong, Kun Gou, Huan Liu, Jing Xu, Yang Zhou, Xia Zhou, Yuanzhi Liu, Zhiqian Chen, Yue Zhou, Yan Li, Lei Tao, Na Su, Lingyun Zhou, Jiahao Qiu, Xinyu Yang, Zeping Zuo, Li Fu, Jingyao Zhang, Dan Li, Cong Li, Qingxiang Sun, Jian Lei, Rui Li, Shengyong Yang, Xiaobo Cen, Yinglan Zhao
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:MedComm
Subjects:
drug combination
GADD45B
hepatocellular carcinoma
LSD1 inhibitor
Online Access:https://doi.org/10.1002/mco2.269

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