First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria)
Background: No recent data are available on hepatitis delta virus (HDV) prevalence in Algeria. For this reason we conducted an epidemiological study, cross-sectional seroprevalence of HDV in the region of Setif. Methods: Between 2011 and 2014, sera samples of 500 patients (carrying HBsAg) admitted...
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| Format: | Article |
| Language: | English |
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AOSIS
2019-10-01
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| Series: | Southern African Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://sajid.co.za/index.php/sajid/article/view/110 |
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| author | Abdelkader Gasmi Wahiba Guenifi Amel Ouyahia Mounira Rais Houda Boukhrissa Abderahmen Hachani Salah Mechakra Slimen Laouamri Abderezak Touabti Abdelmadjid Lacheheb |
| author_facet | Abdelkader Gasmi Wahiba Guenifi Amel Ouyahia Mounira Rais Houda Boukhrissa Abderahmen Hachani Salah Mechakra Slimen Laouamri Abderezak Touabti Abdelmadjid Lacheheb |
| author_sort | Abdelkader Gasmi |
| collection | DOAJ |
| description | Background: No recent data are available on hepatitis delta virus (HDV) prevalence in Algeria. For this reason we conducted an epidemiological study, cross-sectional seroprevalence of HDV in the region of Setif.
Methods: Between 2011 and 2014, sera samples of 500 patients (carrying HBsAg) admitted to the Division of Infectious Diseases Teaching Hospital, Setif (east of Algeria), were tested for anti-HDV-IgG ab (ETI-AB-DeltaK-2).
Results: The prevalence of HDV obtained is estimated at 2.4%. The prevalence ranges from 1% in chronic hepatitis to 11.1% in cirrhotic hepatitis (low endemic area). Seropositivity rate is closely correlated with age (Odds ratio [OR] = 9.98, p = 0.000) and gender (OR = 0.24, p = 0.025); it reaches 58.3% in the age group of 51–60 years and 0% in children (age group 1–15 years); it represents 75% in females and 25% in males. The presence of familial cases of HBsAg positive (OR = 4.54, p = 0.006), the endoscopic procedure (OR = 6.54, p = 0.000) and tattooing (OR = 20, p = 0.000) were found to be the transmission risk factors. A statistically significant relationship was found between the positivity of anti-HDV and advanced liver disease, cirrhosis (OR = 9. 16, p = 0.000). A significant correlation was found between the positivity of anti-HDV with diabetes (OR = 6.83, p = 0.000), obesity (OR = 4.19, p = 0.009) and viral suppression B (OR = 5.69, p = 0.003).
Conclusion: Our results show that HDV infection is low in Algeria. Research for total anti-HDV should be part of the initial assessment of patient care with viral hepatitis B as well as the prevalence of other viruses (hepatitis C [HCV] and HIV). A multicentre study should be carried out to know the importance of HDV infection and identify the risk groups. |
| first_indexed | 2024-12-21T11:28:51Z |
| format | Article |
| id | doaj.art-ab84b63cc8e2457baf9e2b41a3b649fb |
| institution | Directory Open Access Journal |
| issn | 2312-0053 2313-1810 |
| language | English |
| last_indexed | 2024-12-21T11:28:51Z |
| publishDate | 2019-10-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Southern African Journal of Infectious Diseases |
| spelling | doaj.art-ab84b63cc8e2457baf9e2b41a3b649fb2022-12-21T19:05:36ZengAOSISSouthern African Journal of Infectious Diseases2312-00532313-18102019-10-01341e1e610.4102/sajid.v34i1.110127First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria)Abdelkader Gasmi0Wahiba Guenifi1Amel Ouyahia2Mounira Rais3Houda Boukhrissa4Abderahmen Hachani5Salah Mechakra6Slimen Laouamri7Abderezak Touabti8Abdelmadjid Lacheheb9Division of Infectious Diseases Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Infectious Diseases Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Infectious Diseases Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Infectious Diseases Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Infectious Diseases Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Infectious Diseases Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Infectious Diseases Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Epidemiology Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Microbiology Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifDivision of Infectious Diseases Teaching Hospital, Faculty of Medicine, University Ferhat Abbes Setif, SetifBackground: No recent data are available on hepatitis delta virus (HDV) prevalence in Algeria. For this reason we conducted an epidemiological study, cross-sectional seroprevalence of HDV in the region of Setif. Methods: Between 2011 and 2014, sera samples of 500 patients (carrying HBsAg) admitted to the Division of Infectious Diseases Teaching Hospital, Setif (east of Algeria), were tested for anti-HDV-IgG ab (ETI-AB-DeltaK-2). Results: The prevalence of HDV obtained is estimated at 2.4%. The prevalence ranges from 1% in chronic hepatitis to 11.1% in cirrhotic hepatitis (low endemic area). Seropositivity rate is closely correlated with age (Odds ratio [OR] = 9.98, p = 0.000) and gender (OR = 0.24, p = 0.025); it reaches 58.3% in the age group of 51–60 years and 0% in children (age group 1–15 years); it represents 75% in females and 25% in males. The presence of familial cases of HBsAg positive (OR = 4.54, p = 0.006), the endoscopic procedure (OR = 6.54, p = 0.000) and tattooing (OR = 20, p = 0.000) were found to be the transmission risk factors. A statistically significant relationship was found between the positivity of anti-HDV and advanced liver disease, cirrhosis (OR = 9. 16, p = 0.000). A significant correlation was found between the positivity of anti-HDV with diabetes (OR = 6.83, p = 0.000), obesity (OR = 4.19, p = 0.009) and viral suppression B (OR = 5.69, p = 0.003). Conclusion: Our results show that HDV infection is low in Algeria. Research for total anti-HDV should be part of the initial assessment of patient care with viral hepatitis B as well as the prevalence of other viruses (hepatitis C [HCV] and HIV). A multicentre study should be carried out to know the importance of HDV infection and identify the risk groups.https://sajid.co.za/index.php/sajid/article/view/110hepatitis delta virusprevalencerisk factorssetifalgeria. |
| spellingShingle | Abdelkader Gasmi Wahiba Guenifi Amel Ouyahia Mounira Rais Houda Boukhrissa Abderahmen Hachani Salah Mechakra Slimen Laouamri Abderezak Touabti Abdelmadjid Lacheheb First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria) Southern African Journal of Infectious Diseases hepatitis delta virus prevalence risk factors setif algeria. |
| title | First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria) |
| title_full | First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria) |
| title_fullStr | First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria) |
| title_full_unstemmed | First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria) |
| title_short | First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria) |
| title_sort | first study of hepatitis delta virus in algeria seroprevalence and risk factors in setif region east of algeria |
| topic | hepatitis delta virus prevalence risk factors setif algeria. |
| url | https://sajid.co.za/index.php/sajid/article/view/110 |
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