Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in Taiwan
Background: Major depressive disorder (MDD) and dementia are both major contributors to the global burden of disease. Despite existing literature on the association between MDD and dementia, there is a lack of a nationwide longitudinal cohort study that considers the competing risk of death. Therefo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-11-01
|
| Series: | Comprehensive Psychiatry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0010440X23000482 |
| _version_ | 1797647976112324608 |
|---|---|
| author | Chih-Ching Liu Chih-Yuan Lin Chien-Hui Liu Kun-Chia Chang Sheng-Kai Wang Jiun-Yi Wang |
| author_facet | Chih-Ching Liu Chih-Yuan Lin Chien-Hui Liu Kun-Chia Chang Sheng-Kai Wang Jiun-Yi Wang |
| author_sort | Chih-Ching Liu |
| collection | DOAJ |
| description | Background: Major depressive disorder (MDD) and dementia are both major contributors to the global burden of disease. Despite existing literature on the association between MDD and dementia, there is a lack of a nationwide longitudinal cohort study that considers the competing risk of death. Therefore, this study assessed the bidirectional associations between MDD and dementia over an 11-year period in population-based settings, accounting for death as a competing risk. Methods: We conducted two population-based retrospective cohort studies in Taiwan. We identified 80,742 patients diagnosed with MDD in 2009–2010 and matched them with patients without MDD by sex, age, and year of diagnosis to assess the relative risk of dementia. We also identified 80,108 patients diagnosed with dementia in 2009–2010 and matched them with patients without dementia by sex, age, and year of diagnosis to assess the relative risk of MDD. All patients were followed until they received a diagnosis of new onset MDD or new onset dementia, their death, or the end of 2019. Cause-specific hazards models were used to estimate adjusted hazard ratios (aHRs). Results: The incidence density (ID) of dementia was higher in patients with MDD than in patients without MDD (7.63 vs. 2.99 per 1000 person-years), with an aHR of 2.71 (95% confidence interval [CI]: 2.55–2.88). The ID of MDD was higher in patients with dementia than in patients without dementia (12.77 vs. 4.69 per 1000 person-years), with an aHR of 2.47 (95% CI: 2.35–2.59). Conclusions: This population-based study found a bidirectional association between MDD and dementia. Our findings suggest the need to identify dementia in patients with MDD and vice versa. |
| first_indexed | 2024-03-11T15:24:30Z |
| format | Article |
| id | doaj.art-ab85e317d27840daafacb168e2356067 |
| institution | Directory Open Access Journal |
| issn | 0010-440X |
| language | English |
| last_indexed | 2024-03-11T15:24:30Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comprehensive Psychiatry |
| spelling | doaj.art-ab85e317d27840daafacb168e23560672023-10-28T05:06:13ZengElsevierComprehensive Psychiatry0010-440X2023-11-01127152411Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in TaiwanChih-Ching Liu0Chih-Yuan Lin1Chien-Hui Liu2Kun-Chia Chang3Sheng-Kai Wang4Jiun-Yi Wang5Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taiwan; Corresponding authors at: Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taiwan.Department of Neurology, Taipei City Hospital, Linsen Chinese Medicine Branch, Taipei, Taiwan; Institute of Health and Welfare Policy, School of Medicine, National Yang Ming Chiao Tung University, TaiwanInstitute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taiwan; Division of Emergency Medical Service, New Taipei City Fire Department, New Taipei City, TaiwanJianan Psychiatric Center, Ministry of Health and Welfare, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, TaiwanDepartment of Healthcare Administration, College of Medical and Health Science, Asia University, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taiwan; Corresponding authors at: Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taiwan.Background: Major depressive disorder (MDD) and dementia are both major contributors to the global burden of disease. Despite existing literature on the association between MDD and dementia, there is a lack of a nationwide longitudinal cohort study that considers the competing risk of death. Therefore, this study assessed the bidirectional associations between MDD and dementia over an 11-year period in population-based settings, accounting for death as a competing risk. Methods: We conducted two population-based retrospective cohort studies in Taiwan. We identified 80,742 patients diagnosed with MDD in 2009–2010 and matched them with patients without MDD by sex, age, and year of diagnosis to assess the relative risk of dementia. We also identified 80,108 patients diagnosed with dementia in 2009–2010 and matched them with patients without dementia by sex, age, and year of diagnosis to assess the relative risk of MDD. All patients were followed until they received a diagnosis of new onset MDD or new onset dementia, their death, or the end of 2019. Cause-specific hazards models were used to estimate adjusted hazard ratios (aHRs). Results: The incidence density (ID) of dementia was higher in patients with MDD than in patients without MDD (7.63 vs. 2.99 per 1000 person-years), with an aHR of 2.71 (95% confidence interval [CI]: 2.55–2.88). The ID of MDD was higher in patients with dementia than in patients without dementia (12.77 vs. 4.69 per 1000 person-years), with an aHR of 2.47 (95% CI: 2.35–2.59). Conclusions: This population-based study found a bidirectional association between MDD and dementia. Our findings suggest the need to identify dementia in patients with MDD and vice versa.http://www.sciencedirect.com/science/article/pii/S0010440X23000482DementiaMajor depressive disorderCohort studyBidirectional association |
| spellingShingle | Chih-Ching Liu Chih-Yuan Lin Chien-Hui Liu Kun-Chia Chang Sheng-Kai Wang Jiun-Yi Wang Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in Taiwan Comprehensive Psychiatry Dementia Major depressive disorder Cohort study Bidirectional association |
| title | Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in Taiwan |
| title_full | Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in Taiwan |
| title_fullStr | Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in Taiwan |
| title_full_unstemmed | Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in Taiwan |
| title_short | Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in Taiwan |
| title_sort | bidirectional association between major depressive disorder and dementia two population based cohort studies in taiwan |
| topic | Dementia Major depressive disorder Cohort study Bidirectional association |
| url | http://www.sciencedirect.com/science/article/pii/S0010440X23000482 |
| work_keys_str_mv | AT chihchingliu bidirectionalassociationbetweenmajordepressivedisorderanddementiatwopopulationbasedcohortstudiesintaiwan AT chihyuanlin bidirectionalassociationbetweenmajordepressivedisorderanddementiatwopopulationbasedcohortstudiesintaiwan AT chienhuiliu bidirectionalassociationbetweenmajordepressivedisorderanddementiatwopopulationbasedcohortstudiesintaiwan AT kunchiachang bidirectionalassociationbetweenmajordepressivedisorderanddementiatwopopulationbasedcohortstudiesintaiwan AT shengkaiwang bidirectionalassociationbetweenmajordepressivedisorderanddementiatwopopulationbasedcohortstudiesintaiwan AT jiunyiwang bidirectionalassociationbetweenmajordepressivedisorderanddementiatwopopulationbasedcohortstudiesintaiwan |