Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy
PurposeTo evaluate the outcomes and prognostic factors in children with extracranial germ cell tumors (GCTs) treated at a single institution.MethodsSixty-six children diagnosed with extracranial GCTs between 1996 and 2012 were included in the study. Primary treatment was surgical excision, followed...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Pediatric Society
2015-10-01
|
| Series: | Korean Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://kjp.or.kr/upload/pdf/kjped-58-386.pdf |
| _version_ | 1819019291337424896 |
|---|---|
| author | Jinsup Kim Na Hee Lee Soo Hyun Lee Keon Hee Yoo Ki Woong Sung Hong Hoe Koo Jeong-Meen Seo Suk-Koo Lee |
| author_facet | Jinsup Kim Na Hee Lee Soo Hyun Lee Keon Hee Yoo Ki Woong Sung Hong Hoe Koo Jeong-Meen Seo Suk-Koo Lee |
| author_sort | Jinsup Kim |
| collection | DOAJ |
| description | PurposeTo evaluate the outcomes and prognostic factors in children with extracranial germ cell tumors (GCTs) treated at a single institution.MethodsSixty-six children diagnosed with extracranial GCTs between 1996 and 2012 were included in the study. Primary treatment was surgical excision, followed by six cycles of cisplatin-based chemotherapy. The survival rates were compared according to the International Germ Cell Cancer Cooperative Group classification used for GCTs in adults to validate the classification guidelines for GCTs in children.ResultsThe median patient age was 4.4 years. In 34 patients (51.5%), the primary tumor site was the gonad. Extragonadal GCTs were detected in 32 patients. The 5-year overall survival and event-free survival (EFS) were 92.0%±3.5% and 90.4%±3.7%, respectively. In univariate analysis, tumor histology, metastasis, and elevated alpha-fetoprotein were not prognostic factors in children with extracranial GCTs. However, EFS was poorer in patients with mediastinal disease (n=12, 66.7%±13.6 %) than in those with nonmediastinal disease (n=54, 96.0%±2.8%) (P=0.001). The 5-year EFS was lower in patients older than 10 years, (n=21, 80.0%±8.9%) compared with those younger than 10 years (n=45, 95.2%±3.3%) (P=0.04). Multivariate analysis identified the mediastinal tumor site as the only independent prognostic factor.ConclusionThe prognosis of children with extracranial GCTs was favorable. However, nongerminomatous mediastinal tumors were associated with poor survival in children. Further research is needed to improve the prognosis of children with malignant mediastinal GCTs. |
| first_indexed | 2024-12-21T03:32:59Z |
| format | Article |
| id | doaj.art-ab8678416bee4aaba73df1aa7eec9bc4 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-21T03:32:59Z |
| publishDate | 2015-10-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-ab8678416bee4aaba73df1aa7eec9bc42022-12-21T19:17:25ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582015-10-01581038639110.3345/kjp.2015.58.10.3862014600070Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapyJinsup Kim0Na Hee Lee1Soo Hyun Lee2Keon Hee Yoo3Ki Woong Sung4Hong Hoe Koo5Jeong-Meen Seo6Suk-Koo Lee7Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Pediatric Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Pediatric Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.PurposeTo evaluate the outcomes and prognostic factors in children with extracranial germ cell tumors (GCTs) treated at a single institution.MethodsSixty-six children diagnosed with extracranial GCTs between 1996 and 2012 were included in the study. Primary treatment was surgical excision, followed by six cycles of cisplatin-based chemotherapy. The survival rates were compared according to the International Germ Cell Cancer Cooperative Group classification used for GCTs in adults to validate the classification guidelines for GCTs in children.ResultsThe median patient age was 4.4 years. In 34 patients (51.5%), the primary tumor site was the gonad. Extragonadal GCTs were detected in 32 patients. The 5-year overall survival and event-free survival (EFS) were 92.0%±3.5% and 90.4%±3.7%, respectively. In univariate analysis, tumor histology, metastasis, and elevated alpha-fetoprotein were not prognostic factors in children with extracranial GCTs. However, EFS was poorer in patients with mediastinal disease (n=12, 66.7%±13.6 %) than in those with nonmediastinal disease (n=54, 96.0%±2.8%) (P=0.001). The 5-year EFS was lower in patients older than 10 years, (n=21, 80.0%±8.9%) compared with those younger than 10 years (n=45, 95.2%±3.3%) (P=0.04). Multivariate analysis identified the mediastinal tumor site as the only independent prognostic factor.ConclusionThe prognosis of children with extracranial GCTs was favorable. However, nongerminomatous mediastinal tumors were associated with poor survival in children. Further research is needed to improve the prognosis of children with malignant mediastinal GCTs.http://kjp.or.kr/upload/pdf/kjped-58-386.pdfGerm cell and embryonal neoplasmsChildPrognosisMediastinumSurvival |
| spellingShingle | Jinsup Kim Na Hee Lee Soo Hyun Lee Keon Hee Yoo Ki Woong Sung Hong Hoe Koo Jeong-Meen Seo Suk-Koo Lee Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy Korean Journal of Pediatrics Germ cell and embryonal neoplasms Child Prognosis Mediastinum Survival |
| title | Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy |
| title_full | Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy |
| title_fullStr | Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy |
| title_full_unstemmed | Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy |
| title_short | Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy |
| title_sort | prognostic factors in children with extracranial germ cell tumors treated with cisplatin based chemotherapy |
| topic | Germ cell and embryonal neoplasms Child Prognosis Mediastinum Survival |
| url | http://kjp.or.kr/upload/pdf/kjped-58-386.pdf |
| work_keys_str_mv | AT jinsupkim prognosticfactorsinchildrenwithextracranialgermcelltumorstreatedwithcisplatinbasedchemotherapy AT naheelee prognosticfactorsinchildrenwithextracranialgermcelltumorstreatedwithcisplatinbasedchemotherapy AT soohyunlee prognosticfactorsinchildrenwithextracranialgermcelltumorstreatedwithcisplatinbasedchemotherapy AT keonheeyoo prognosticfactorsinchildrenwithextracranialgermcelltumorstreatedwithcisplatinbasedchemotherapy AT kiwoongsung prognosticfactorsinchildrenwithextracranialgermcelltumorstreatedwithcisplatinbasedchemotherapy AT honghoekoo prognosticfactorsinchildrenwithextracranialgermcelltumorstreatedwithcisplatinbasedchemotherapy AT jeongmeenseo prognosticfactorsinchildrenwithextracranialgermcelltumorstreatedwithcisplatinbasedchemotherapy AT sukkoolee prognosticfactorsinchildrenwithextracranialgermcelltumorstreatedwithcisplatinbasedchemotherapy |