Ezogabine skin discoloration is reversible after discontinuation
There is concern that bluish skin discoloration associated with ezogabine treatment could be permanent. We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400 mg three times a day at age 41. Bluish pigmentat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Epilepsy and Behavior Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213323216300706 |
| _version_ | 1811274178228125696 |
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| author | Sally V. Mathias Bassel W. Abou-Khalil |
| author_facet | Sally V. Mathias Bassel W. Abou-Khalil |
| author_sort | Sally V. Mathias |
| collection | DOAJ |
| description | There is concern that bluish skin discoloration associated with ezogabine treatment could be permanent. We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400 mg three times a day at age 41. Bluish pigmentation over the toe nails, finger nails, around eyes and over and around lips was first noted after 5 years of treatment. Ezogabine was discontinued eight years after initiation. Skin discoloration improved within 6 months and completely resolved within 6 years of discontinuation. This case suggests that ezogabine-induced discoloration is reversible after discontinuation of treatment. |
| first_indexed | 2024-04-12T23:14:13Z |
| format | Article |
| id | doaj.art-ab89ece4d5654f9cb5ed4191d99a85c8 |
| institution | Directory Open Access Journal |
| issn | 2213-3232 |
| language | English |
| last_indexed | 2024-04-12T23:14:13Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy and Behavior Case Reports |
| spelling | doaj.art-ab89ece4d5654f9cb5ed4191d99a85c82022-12-22T03:12:44ZengElsevierEpilepsy and Behavior Case Reports2213-32322017-01-017C616310.1016/j.ebcr.2017.01.001Ezogabine skin discoloration is reversible after discontinuationSally V. MathiasBassel W. Abou-KhalilThere is concern that bluish skin discoloration associated with ezogabine treatment could be permanent. We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400 mg three times a day at age 41. Bluish pigmentation over the toe nails, finger nails, around eyes and over and around lips was first noted after 5 years of treatment. Ezogabine was discontinued eight years after initiation. Skin discoloration improved within 6 months and completely resolved within 6 years of discontinuation. This case suggests that ezogabine-induced discoloration is reversible after discontinuation of treatment.http://www.sciencedirect.com/science/article/pii/S2213323216300706EzogabineRetigabineAnti-seizure drugSide effectSkin discolorationReversibility |
| spellingShingle | Sally V. Mathias Bassel W. Abou-Khalil Ezogabine skin discoloration is reversible after discontinuation Epilepsy and Behavior Case Reports Ezogabine Retigabine Anti-seizure drug Side effect Skin discoloration Reversibility |
| title | Ezogabine skin discoloration is reversible after discontinuation |
| title_full | Ezogabine skin discoloration is reversible after discontinuation |
| title_fullStr | Ezogabine skin discoloration is reversible after discontinuation |
| title_full_unstemmed | Ezogabine skin discoloration is reversible after discontinuation |
| title_short | Ezogabine skin discoloration is reversible after discontinuation |
| title_sort | ezogabine skin discoloration is reversible after discontinuation |
| topic | Ezogabine Retigabine Anti-seizure drug Side effect Skin discoloration Reversibility |
| url | http://www.sciencedirect.com/science/article/pii/S2213323216300706 |
| work_keys_str_mv | AT sallyvmathias ezogabineskindiscolorationisreversibleafterdiscontinuation AT basselwaboukhalil ezogabineskindiscolorationisreversibleafterdiscontinuation |