Multidrug-Resistant <i>Escherichia coli</i> Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region
Failure in antibiotic therapies due to the increase in antimicrobial-resistant (AMR) bacteria is one of the main threats to public and animal health. In recent decades, the perception of companion animals has changed, from being considered as a work tool to a household member, creating a family bond...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/11/1638 |
| _version_ | 1797460416200179712 |
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| author | Ana Marco-Fuertes Jaume Jordá Clara Marin Laura Lorenzo-Rebenaque Laura Montoro-Dasi Santiago Vega |
| author_facet | Ana Marco-Fuertes Jaume Jordá Clara Marin Laura Lorenzo-Rebenaque Laura Montoro-Dasi Santiago Vega |
| author_sort | Ana Marco-Fuertes |
| collection | DOAJ |
| description | Failure in antibiotic therapies due to the increase in antimicrobial-resistant (AMR) bacteria is one of the main threats to public and animal health. In recent decades, the perception of companion animals has changed, from being considered as a work tool to a household member, creating a family bond and sharing spaces in their daily routine. Hence, the aim of this study is to assess the current epidemiological situation regarding the presence of AMR and multidrug resistance (MDR) in companion animals in the Valencia Region, using the indicator bacteria <i>Escherichia coli</i> as a sentinel. For this purpose, 244 samples of dogs and cats were collected from veterinary centres to assess antimicrobial susceptibility against a panel of 22 antibiotics with public health relevance. A total of 197 <i>E. coli</i> strains were isolated from asymptomatic dogs and cats. The results showed AMR against all the 22 antibiotics studied, including those critically important to human medicine. Moreover, almost 50% of the strains presented MDR. The present study revealed the importance of monitoring AMR and MDR trends in companion animals, as they could pose a risk due to the spread of AMR and its resistance genes to humans, other animals and the environment they cohabit. |
| first_indexed | 2024-03-09T17:04:45Z |
| format | Article |
| id | doaj.art-ab8a810646e643a083938b861395557d |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T17:04:45Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ab8a810646e643a083938b861395557d2023-11-24T14:25:27ZengMDPI AGAntibiotics2079-63822023-11-011211163810.3390/antibiotics12111638Multidrug-Resistant <i>Escherichia coli</i> Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia RegionAna Marco-Fuertes0Jaume Jordá1Clara Marin2Laura Lorenzo-Rebenaque3Laura Montoro-Dasi4Santiago Vega5Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Instituto de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Santiago Ramón y Cajal 20, Alfara del Patriarca, 45115 Valencia, SpainDepartamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Instituto de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Santiago Ramón y Cajal 20, Alfara del Patriarca, 45115 Valencia, SpainDepartamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Instituto de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Santiago Ramón y Cajal 20, Alfara del Patriarca, 45115 Valencia, SpainInstitute of Animal Science and Technology, Universitat Politècnica de València, 46022 Valencia, SpainDepartamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Instituto de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Santiago Ramón y Cajal 20, Alfara del Patriarca, 45115 Valencia, SpainDepartamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Instituto de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Santiago Ramón y Cajal 20, Alfara del Patriarca, 45115 Valencia, SpainFailure in antibiotic therapies due to the increase in antimicrobial-resistant (AMR) bacteria is one of the main threats to public and animal health. In recent decades, the perception of companion animals has changed, from being considered as a work tool to a household member, creating a family bond and sharing spaces in their daily routine. Hence, the aim of this study is to assess the current epidemiological situation regarding the presence of AMR and multidrug resistance (MDR) in companion animals in the Valencia Region, using the indicator bacteria <i>Escherichia coli</i> as a sentinel. For this purpose, 244 samples of dogs and cats were collected from veterinary centres to assess antimicrobial susceptibility against a panel of 22 antibiotics with public health relevance. A total of 197 <i>E. coli</i> strains were isolated from asymptomatic dogs and cats. The results showed AMR against all the 22 antibiotics studied, including those critically important to human medicine. Moreover, almost 50% of the strains presented MDR. The present study revealed the importance of monitoring AMR and MDR trends in companion animals, as they could pose a risk due to the spread of AMR and its resistance genes to humans, other animals and the environment they cohabit.https://www.mdpi.com/2079-6382/12/11/1638antimicrobial resistancecatscommensal bacteriadogsone health |
| spellingShingle | Ana Marco-Fuertes Jaume Jordá Clara Marin Laura Lorenzo-Rebenaque Laura Montoro-Dasi Santiago Vega Multidrug-Resistant <i>Escherichia coli</i> Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region Antibiotics antimicrobial resistance cats commensal bacteria dogs one health |
| title | Multidrug-Resistant <i>Escherichia coli</i> Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region |
| title_full | Multidrug-Resistant <i>Escherichia coli</i> Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region |
| title_fullStr | Multidrug-Resistant <i>Escherichia coli</i> Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region |
| title_full_unstemmed | Multidrug-Resistant <i>Escherichia coli</i> Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region |
| title_short | Multidrug-Resistant <i>Escherichia coli</i> Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region |
| title_sort | multidrug resistant i escherichia coli i strains to last resort human antibiotics isolated from healthy companion animals in valencia region |
| topic | antimicrobial resistance cats commensal bacteria dogs one health |
| url | https://www.mdpi.com/2079-6382/12/11/1638 |
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