A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling
Breast cancer remains a major health problem worldwide. While chemotherapy represents an important therapeutic modality against breast cancer, limitations in the clinical use of chemotherapy remain formidable because of chemoresistance. The HER2/PI-3K/Akt pathway has been demonstrated to play a caus...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-03-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/10/4/694/ |
| _version_ | 1798006408655929344 |
|---|---|
| author | Mengfeng Li Yongcheng Lin Zhigang She Shengping Chen Lili Zhong Hong Chen Henan Zhang Wan Yang Min Lin Qianhui Zhang Cuiji Lin Yiwen Hu Yi Jiang Jie Yuan Weitao Wen Zhenjian He Jueheng Wu Xun Zhu |
| author_facet | Mengfeng Li Yongcheng Lin Zhigang She Shengping Chen Lili Zhong Hong Chen Henan Zhang Wan Yang Min Lin Qianhui Zhang Cuiji Lin Yiwen Hu Yi Jiang Jie Yuan Weitao Wen Zhenjian He Jueheng Wu Xun Zhu |
| author_sort | Mengfeng Li |
| collection | DOAJ |
| description | Breast cancer remains a major health problem worldwide. While chemotherapy represents an important therapeutic modality against breast cancer, limitations in the clinical use of chemotherapy remain formidable because of chemoresistance. The HER2/PI-3K/Akt pathway has been demonstrated to play a causal role in conferring a broad chemoresistance in breast cancer cells and thus justified to be a target for enhancing the effects of anti-breast cancer chemotherapies, such as adriamycin (ADR). Agents that can either enhance the effects of chemotherapeutics or overcome chemoresistance are urgently needed for the treatment of breast cancer. In this context, SZ-685C, an agent that has been previously shown, as such, to suppress Akt signaling, is expected to increase the efficacy of chemotherapy. Our current study investigated whether SZ-685C can override chemoresistance through inhibiting Akt signaling in human breast cancer cells. ADR-resistant cells derived from human breast cancer cell lines MCF-7, MCF-7/ADR and MCF-7/Akt, were used as models to test the effects of SZ-685C. We found that SZ-685C suppressed the Akt pathway and induced apoptosis in MCF-7/ADR and MCF-7/Akt cells that are resistant to ADR treatment, leading to antitumor effects both in vitro and in vivo. Our data suggest that use of SZ-685C might represent a potentially promising approach to the treatment of ADR-resistant breast cancer. |
| first_indexed | 2024-04-11T12:54:18Z |
| format | Article |
| id | doaj.art-ab8b35f6473741a9b20c101c3fa50b56 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:54:18Z |
| publishDate | 2012-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ab8b35f6473741a9b20c101c3fa50b562022-12-22T04:23:06ZengMDPI AGMarine Drugs1660-33972012-03-0110469471110.3390/md10040694A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt SignalingMengfeng LiYongcheng LinZhigang SheShengping ChenLili ZhongHong ChenHenan ZhangWan YangMin LinQianhui ZhangCuiji LinYiwen HuYi JiangJie YuanWeitao WenZhenjian HeJueheng WuXun ZhuBreast cancer remains a major health problem worldwide. While chemotherapy represents an important therapeutic modality against breast cancer, limitations in the clinical use of chemotherapy remain formidable because of chemoresistance. The HER2/PI-3K/Akt pathway has been demonstrated to play a causal role in conferring a broad chemoresistance in breast cancer cells and thus justified to be a target for enhancing the effects of anti-breast cancer chemotherapies, such as adriamycin (ADR). Agents that can either enhance the effects of chemotherapeutics or overcome chemoresistance are urgently needed for the treatment of breast cancer. In this context, SZ-685C, an agent that has been previously shown, as such, to suppress Akt signaling, is expected to increase the efficacy of chemotherapy. Our current study investigated whether SZ-685C can override chemoresistance through inhibiting Akt signaling in human breast cancer cells. ADR-resistant cells derived from human breast cancer cell lines MCF-7, MCF-7/ADR and MCF-7/Akt, were used as models to test the effects of SZ-685C. We found that SZ-685C suppressed the Akt pathway and induced apoptosis in MCF-7/ADR and MCF-7/Akt cells that are resistant to ADR treatment, leading to antitumor effects both in vitro and in vivo. Our data suggest that use of SZ-685C might represent a potentially promising approach to the treatment of ADR-resistant breast cancer.http://www.mdpi.com/1660-3397/10/4/694/SZ-685Cbreast cancerchemoresistanceAkt |
| spellingShingle | Mengfeng Li Yongcheng Lin Zhigang She Shengping Chen Lili Zhong Hong Chen Henan Zhang Wan Yang Min Lin Qianhui Zhang Cuiji Lin Yiwen Hu Yi Jiang Jie Yuan Weitao Wen Zhenjian He Jueheng Wu Xun Zhu A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling Marine Drugs SZ-685C breast cancer chemoresistance Akt |
| title | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
| title_full | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
| title_fullStr | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
| title_full_unstemmed | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
| title_short | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
| title_sort | marine anthraquinone sz 685c overrides adriamycin resistance in breast cancer cells through suppressing akt signaling |
| topic | SZ-685C breast cancer chemoresistance Akt |
| url | http://www.mdpi.com/1660-3397/10/4/694/ |
| work_keys_str_mv | AT mengfengli amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yongchenglin amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhigangshe amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT shengpingchen amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT lilizhong amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT hongchen amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT henanzhang amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT wanyang amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT minlin amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT qianhuizhang amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT cuijilin amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yiwenhu amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yijiang amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT jieyuan amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT weitaowen amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhenjianhe amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT juehengwu amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT xunzhu amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT mengfengli marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yongchenglin marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhigangshe marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT shengpingchen marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT lilizhong marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT hongchen marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT henanzhang marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT wanyang marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT minlin marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT qianhuizhang marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT cuijilin marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yiwenhu marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yijiang marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT jieyuan marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT weitaowen marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhenjianhe marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT juehengwu marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT xunzhu marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling |