Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome.
Nakalanga syndrome is a condition that was described in Uganda and various other African countries decades ago. Its features include growth retardation, physical deformities, endocrine dysfunction, mental impairment, and epilepsy, amongst others. Its cause remains obscure. Nodding syndrome is a neur...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-02-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC5300103?pdf=render |
| _version_ | 1818937796392386560 |
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| author | Kathrin Föger Gina Gora-Stahlberg James Sejvar Emilio Ovuga Louise Jilek-Aall Erich Schmutzhard Christoph Kaiser Andrea S Winkler |
| author_facet | Kathrin Föger Gina Gora-Stahlberg James Sejvar Emilio Ovuga Louise Jilek-Aall Erich Schmutzhard Christoph Kaiser Andrea S Winkler |
| author_sort | Kathrin Föger |
| collection | DOAJ |
| description | Nakalanga syndrome is a condition that was described in Uganda and various other African countries decades ago. Its features include growth retardation, physical deformities, endocrine dysfunction, mental impairment, and epilepsy, amongst others. Its cause remains obscure. Nodding syndrome is a neurological disorder with some features in common with Nakalanga syndrome, which has been described mainly in Uganda, South Sudan, and Tanzania. It has been considered an encephalopathy affecting children who, besides head nodding attacks, can also present with stunted growth, delayed puberty, and mental impairment, amongst other symptoms. Despite active research over the last years on the pathogenesis of Nodding syndrome, to date, no convincing single cause of Nodding syndrome has been reported. In this review, by means of a thorough literature search, we compare features of both disorders. We conclude that Nakalanga and Nodding syndromes are closely related and may represent the same condition. Our findings may provide new directions in research on the cause underlying this neurological disorder. |
| first_indexed | 2024-12-20T05:57:39Z |
| format | Article |
| id | doaj.art-ab8bcba74cb54d1c88122c4592bbdc83 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-20T05:57:39Z |
| publishDate | 2017-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-ab8bcba74cb54d1c88122c4592bbdc832022-12-21T19:50:58ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352017-02-01112e000520110.1371/journal.pntd.0005201Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome.Kathrin FögerGina Gora-StahlbergJames SejvarEmilio OvugaLouise Jilek-AallErich SchmutzhardChristoph KaiserAndrea S WinklerNakalanga syndrome is a condition that was described in Uganda and various other African countries decades ago. Its features include growth retardation, physical deformities, endocrine dysfunction, mental impairment, and epilepsy, amongst others. Its cause remains obscure. Nodding syndrome is a neurological disorder with some features in common with Nakalanga syndrome, which has been described mainly in Uganda, South Sudan, and Tanzania. It has been considered an encephalopathy affecting children who, besides head nodding attacks, can also present with stunted growth, delayed puberty, and mental impairment, amongst other symptoms. Despite active research over the last years on the pathogenesis of Nodding syndrome, to date, no convincing single cause of Nodding syndrome has been reported. In this review, by means of a thorough literature search, we compare features of both disorders. We conclude that Nakalanga and Nodding syndromes are closely related and may represent the same condition. Our findings may provide new directions in research on the cause underlying this neurological disorder.http://europepmc.org/articles/PMC5300103?pdf=render |
| spellingShingle | Kathrin Föger Gina Gora-Stahlberg James Sejvar Emilio Ovuga Louise Jilek-Aall Erich Schmutzhard Christoph Kaiser Andrea S Winkler Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome. PLoS Neglected Tropical Diseases |
| title | Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome. |
| title_full | Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome. |
| title_fullStr | Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome. |
| title_full_unstemmed | Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome. |
| title_short | Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome. |
| title_sort | nakalanga syndrome clinical characteristics potential causes and its relationship with recently described nodding syndrome |
| url | http://europepmc.org/articles/PMC5300103?pdf=render |
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