Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

Although it has been known for over a decade that the inflammatory mediator NGF sensitizes pain-receptor neurons through increased trafficking of TRPV1 channels to the plasma membrane, the mechanism by which this occurs remains mysterious. NGF activates phosphoinositide 3-kinase (PI3K), the enzyme t...

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Bibliographic Details
Main Authors: Anastasiia Stratiievska, Sara Nelson, Eric N Senning, Jonathan D Lautz, Stephen EP Smith, Sharona E Gordon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
TRPV1
NGF
PI3K
inflammation
PIP3
TRPV2
Online Access:https://elifesciences.org/articles/38869

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