Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy
Abstract Weight reduction therapy represents a fundamental strategy to prevent nonalcoholic fatty liver disease (NAFLD) in patients with obesity, which may result in liver fibrosis. Histological findings previously demonstrated that weight reduction therapy attenuated NAFLD. The FIB4 index is widely...
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| Format: | Article |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-19420-0 |
| _version_ | 1811211780719902720 |
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| author | Shiori Kawai Hajime Yamakage Kazuhiko Kotani Mitsuhiko Noda Noriko Satoh-Asahara Koshi Hashimoto |
| author_facet | Shiori Kawai Hajime Yamakage Kazuhiko Kotani Mitsuhiko Noda Noriko Satoh-Asahara Koshi Hashimoto |
| author_sort | Shiori Kawai |
| collection | DOAJ |
| description | Abstract Weight reduction therapy represents a fundamental strategy to prevent nonalcoholic fatty liver disease (NAFLD) in patients with obesity, which may result in liver fibrosis. Histological findings previously demonstrated that weight reduction therapy attenuated NAFLD. The FIB4 index is widely used to assess the status of NAFLD. The present study investigated whether the FIB4 index improved during weight reduction therapy. We used cohort data of the Japan Obesity and Metabolic syndrome Study and examined the correlation between body weight (BW) loss (BW loss) and changes in the FIB4 index (ΔFIB4 index) in patients who successfully reduced their BW by more than 5% from baseline BW after 3, 6, and 12 months (M) of weight reduction therapy. A negative correlation (r = −0.342, p = 0.029) was observed between BW loss and FIB4 index after 3 M, but not after 6 M, whereas a positive correlation (r = 0.298, p = 0.03) was noted after 12 M. These results revealed changes in the correlation between ΔBW loss and ΔFIB4 index during the therapy, mainly due to time-dependent changes in components of the FIB4 index formula. Thus, we concluded that the FIB4 index is useful and reliable to assess liver fibrosis until 3 M during weight reduction therapy. However, after 3 M, we should recognize that the FIB4 index may not reflect liver status. Therefore, it is important to consider this characteristic of the FIB4 index as a limitation when assessing liver fibrosis in obese patients receiving weight reduction therapy. |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T05:18:32Z |
| publishDate | 2022-09-01 |
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| series | Scientific Reports |
| spelling | doaj.art-ab8c3ce9cf5d49658f02e961676504d62022-12-22T03:46:34ZengNature PortfolioScientific Reports2045-23222022-09-0112111110.1038/s41598-022-19420-0Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapyShiori Kawai0Hajime Yamakage1Kazuhiko Kotani2Mitsuhiko Noda3Noriko Satoh-Asahara4Koshi Hashimoto5Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical CenterDivision of Diabetic Research, Clinical Research Institute, National Hospital Organization Kyoto Medical CenterDivision of Community and Family Medicine, Jichi Medical UniversityDepartment of Diabetes, Metabolism and Endocrinology, Ichikawa Hospital, International University of Health and WelfareDivision of Diabetic Research, Clinical Research Institute, National Hospital Organization Kyoto Medical CenterDepartment of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical CenterAbstract Weight reduction therapy represents a fundamental strategy to prevent nonalcoholic fatty liver disease (NAFLD) in patients with obesity, which may result in liver fibrosis. Histological findings previously demonstrated that weight reduction therapy attenuated NAFLD. The FIB4 index is widely used to assess the status of NAFLD. The present study investigated whether the FIB4 index improved during weight reduction therapy. We used cohort data of the Japan Obesity and Metabolic syndrome Study and examined the correlation between body weight (BW) loss (BW loss) and changes in the FIB4 index (ΔFIB4 index) in patients who successfully reduced their BW by more than 5% from baseline BW after 3, 6, and 12 months (M) of weight reduction therapy. A negative correlation (r = −0.342, p = 0.029) was observed between BW loss and FIB4 index after 3 M, but not after 6 M, whereas a positive correlation (r = 0.298, p = 0.03) was noted after 12 M. These results revealed changes in the correlation between ΔBW loss and ΔFIB4 index during the therapy, mainly due to time-dependent changes in components of the FIB4 index formula. Thus, we concluded that the FIB4 index is useful and reliable to assess liver fibrosis until 3 M during weight reduction therapy. However, after 3 M, we should recognize that the FIB4 index may not reflect liver status. Therefore, it is important to consider this characteristic of the FIB4 index as a limitation when assessing liver fibrosis in obese patients receiving weight reduction therapy.https://doi.org/10.1038/s41598-022-19420-0 |
| spellingShingle | Shiori Kawai Hajime Yamakage Kazuhiko Kotani Mitsuhiko Noda Noriko Satoh-Asahara Koshi Hashimoto Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy Scientific Reports |
| title | Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy |
| title_full | Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy |
| title_fullStr | Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy |
| title_full_unstemmed | Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy |
| title_short | Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy |
| title_sort | analysis of time dependent changes in the fib4 index in patients with obesity receiving weight reduction therapy |
| url | https://doi.org/10.1038/s41598-022-19420-0 |
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