The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
Abstract As interest in space exploration rises, there is a growing need to quantify the impact of microgravity on the growth, survival, and adaptation of microorganisms, including those responsible for astronaut illness. Motility is a key microbial behavior that plays important roles in nutrient as...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-021-00135-x |
| _version_ | 1797641698817343488 |
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| author | Jacqueline M. Acres Myka Jaap Youngapelian Jay Nadeau |
| author_facet | Jacqueline M. Acres Myka Jaap Youngapelian Jay Nadeau |
| author_sort | Jacqueline M. Acres |
| collection | DOAJ |
| description | Abstract As interest in space exploration rises, there is a growing need to quantify the impact of microgravity on the growth, survival, and adaptation of microorganisms, including those responsible for astronaut illness. Motility is a key microbial behavior that plays important roles in nutrient assimilation, tissue localization and invasion, pathogenicity, biofilm formation, and ultimately survival. Very few studies have specifically looked at the effects of microgravity on the phenotypes of microbial motility. However, genomic and transcriptomic studies give a broad general picture of overall gene expression that can be used to predict motility phenotypes based upon selected genes, such as those responsible for flagellar synthesis and function and/or taxis. In this review, we focus on specific strains of Gram-negative bacteria that have been the most studied in this context. We begin with a discussion of Earth-based microgravity simulation systems and how they may affect the genes and phenotypes of interest. We then summarize results from both Earth- and space-based systems showing effects of microgravity on motility-related genes and phenotypes. |
| first_indexed | 2024-03-11T13:49:27Z |
| format | Article |
| id | doaj.art-ab8e96e5c9f145329132f9f5637eeb2e |
| institution | Directory Open Access Journal |
| issn | 2373-8065 |
| language | English |
| last_indexed | 2024-03-11T13:49:27Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj.art-ab8e96e5c9f145329132f9f5637eeb2e2023-11-02T09:23:50ZengNature Portfolionpj Microgravity2373-80652021-02-017111110.1038/s41526-021-00135-xThe influence of spaceflight and simulated microgravity on bacterial motility and chemotaxisJacqueline M. Acres0Myka Jaap Youngapelian1Jay Nadeau2Portland State UniversityPortland State UniversityPortland State UniversityAbstract As interest in space exploration rises, there is a growing need to quantify the impact of microgravity on the growth, survival, and adaptation of microorganisms, including those responsible for astronaut illness. Motility is a key microbial behavior that plays important roles in nutrient assimilation, tissue localization and invasion, pathogenicity, biofilm formation, and ultimately survival. Very few studies have specifically looked at the effects of microgravity on the phenotypes of microbial motility. However, genomic and transcriptomic studies give a broad general picture of overall gene expression that can be used to predict motility phenotypes based upon selected genes, such as those responsible for flagellar synthesis and function and/or taxis. In this review, we focus on specific strains of Gram-negative bacteria that have been the most studied in this context. We begin with a discussion of Earth-based microgravity simulation systems and how they may affect the genes and phenotypes of interest. We then summarize results from both Earth- and space-based systems showing effects of microgravity on motility-related genes and phenotypes.https://doi.org/10.1038/s41526-021-00135-x |
| spellingShingle | Jacqueline M. Acres Myka Jaap Youngapelian Jay Nadeau The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis npj Microgravity |
| title | The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis |
| title_full | The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis |
| title_fullStr | The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis |
| title_full_unstemmed | The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis |
| title_short | The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis |
| title_sort | influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis |
| url | https://doi.org/10.1038/s41526-021-00135-x |
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