Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact
Chronic lymphocyte leukemia (CLL) is the most common leukemia in elderly individuals that is accompanied by the presence of CD5/CD19/CD20/CD23 positive, FMC7 negative and reduced levels of surface membrane Immunoglobuline (IgM & IgD), CD79b on B lymphocytes in the blood, bone marrow and lymph no...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2017-02-01
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| Series: | Basic & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/218 |
| _version_ | 1798023736716165120 |
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| author | Mehrnoosh Pashaei Mahdieh Shokrollahi Parviz Kokhaei |
| author_facet | Mehrnoosh Pashaei Mahdieh Shokrollahi Parviz Kokhaei |
| author_sort | Mehrnoosh Pashaei |
| collection | DOAJ |
| description | Chronic lymphocyte leukemia (CLL) is the most common leukemia in elderly individuals that is accompanied by the presence of CD5/CD19/CD20/CD23 positive, FMC7 negative and reduced levels of surface membrane Immunoglobuline (IgM & IgD), CD79b on B lymphocytes in the blood, bone marrow and lymph nodes. Remarkably, based on the mutational IgVH status, B-CLL cases can be subdivided into two prognostic groups: the first one with presence mutation (≥ 2%) in VH gene and second one with absence mutation (≤ 2%) in VH gene that is the mutation of IgVH status, affected on progression and overall survival of CLL patients. Correspondingly, also the expression level of several markers is correlated with the mutation of IgVH status and prognosis of CLL disease. In this review we focused on relation between mutation IgVH status and CLL prognosis and overall survival and also some cellular markers which may affect CLL clinical status. |
| first_indexed | 2024-04-11T17:51:14Z |
| format | Article |
| id | doaj.art-ab90cb79fa1e4998b59cafc8d9b68962 |
| institution | Directory Open Access Journal |
| issn | 2228-6527 2228-5466 |
| language | English |
| last_indexed | 2024-04-11T17:51:14Z |
| publishDate | 2017-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj.art-ab90cb79fa1e4998b59cafc8d9b689622022-12-22T04:11:06ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662017-02-0184Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic ImpactMehrnoosh Pashaei0Mahdieh Shokrollahi1Parviz Kokhaei2Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences,Semnan, Iran.Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran. AND Immunology, Asthma and AllergyResearch Center, Tehran Universityof Medical Sciences, Tehran, Iran.Department of immunology, Semnan University of Medical Sciences, Semnan, Iran. AND Immune Gene therapy Lab Department of Oncology-Pathology,Immune and Gene therapy Lab,Cancer Center Karolinska , Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden.Chronic lymphocyte leukemia (CLL) is the most common leukemia in elderly individuals that is accompanied by the presence of CD5/CD19/CD20/CD23 positive, FMC7 negative and reduced levels of surface membrane Immunoglobuline (IgM & IgD), CD79b on B lymphocytes in the blood, bone marrow and lymph nodes. Remarkably, based on the mutational IgVH status, B-CLL cases can be subdivided into two prognostic groups: the first one with presence mutation (≥ 2%) in VH gene and second one with absence mutation (≤ 2%) in VH gene that is the mutation of IgVH status, affected on progression and overall survival of CLL patients. Correspondingly, also the expression level of several markers is correlated with the mutation of IgVH status and prognosis of CLL disease. In this review we focused on relation between mutation IgVH status and CLL prognosis and overall survival and also some cellular markers which may affect CLL clinical status.https://bccr.tums.ac.ir/index.php/bccrj/article/view/218CLLmutation IgVH statusprognosis factoroverall survival |
| spellingShingle | Mehrnoosh Pashaei Mahdieh Shokrollahi Parviz Kokhaei Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact Basic & Clinical Cancer Research CLL mutation IgVH status prognosis factor overall survival |
| title | Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact |
| title_full | Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact |
| title_fullStr | Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact |
| title_full_unstemmed | Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact |
| title_short | Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact |
| title_sort | somatic mutation in immunoglobulin gene variable region in patients with chronic lymphocytic leukemia and prognostic impact |
| topic | CLL mutation IgVH status prognosis factor overall survival |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/218 |
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