11C-PIB PET and 18F-FDG PET in patients with Alzheimer's disease and amnestic mild cognitive impairment
<p><strong>Objective</strong> The present study investigated the relationship between amyloid deposition and glucose metabolism using Pittsburgh compound B (<sup>11</sup>C-PIB) and fluorodeoxyglucose (<sup>18</sup>F-FDG) positron-emission tomography (PET)...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2014-03-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/915 |
| _version_ | 1811263401983213568 |
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| author | Zhihong Shi Ying Wang Shuai Liu Shuling Liu Yuying Zhou Jinhuan Wang Li Cai Shuo Gao Yong Ji |
| author_facet | Zhihong Shi Ying Wang Shuai Liu Shuling Liu Yuying Zhou Jinhuan Wang Li Cai Shuo Gao Yong Ji |
| author_sort | Zhihong Shi |
| collection | DOAJ |
| description | <p><strong>Objective</strong> The present study investigated the relationship between amyloid deposition and glucose metabolism using Pittsburgh compound B (<sup>11</sup>C-PIB) and fluorodeoxyglucose (<sup>18</sup>F-FDG) positron-emission tomography (PET) in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) and assessed the apolipoprotein E (<em>ApoE</em>) ε4 allele to explore the correlation between aMCI and AD. <strong>Methods</strong> Amyloid load in the brain and cerebral glucose metabolism were determined and <em>ApoE</em> genotypes were analyzed in patients with AD (N = 14), aMCI (N = 10), and healthy controls (N = 5). <strong>Results </strong>The mean <sup>11</sup>C-PIB standardized uptake value ratio (SUVR) was higher in inferior parietal lobe, lateral temporal cortex, frontal cortex, posterior cingulate cortex and precuneus, occipital lobe, and striatum in AD patients compared with controls (<em>P</em> < 0.05). <sup>11</sup>C-PIB binding levels in aMCI patients were bimodal. No significant difference in the <sup>11</sup>C-PIB SUVR was found between the <sup>11</sup>C-PIB + aMCI subgroup and AD group (<em>P</em> > 0.05). <sup>18</sup>F-FDG PET revealed hypometabolism in bilateral parietal lobes, temporal lobe, and precuneus in 3 of 5 <sup>11</sup>C-PIB + aMCI subjects, including two of them with <em>ApoE ε 4</em> allele converted to AD, and hypometabolism in the bilateral frontal lobe and anterior cingulate in 3 of 5 <sup>11</sup>C-PIB - aMCI subjects. <strong>Conclusions</strong> <sup>11</sup>C-PIB PET is a powerful tool for screening aMCI with AD pathology. The aMCI patients with AD pathology who presented hypometabolism in the parietal lobe, lateral temporal cortex, precuneus and with <em>ApoE ε 4</em> allele are more likely to convert to clinical AD dementia.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.03.013</p> |
| first_indexed | 2024-04-12T19:44:30Z |
| format | Article |
| id | doaj.art-ab91c672046d4bb98e2bf2d72e70694e |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-12T19:44:30Z |
| publishDate | 2014-03-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-ab91c672046d4bb98e2bf2d72e70694e2022-12-22T03:19:00ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312014-03-0114322223191411C-PIB PET and 18F-FDG PET in patients with Alzheimer's disease and amnestic mild cognitive impairmentZhihong Shi0Ying Wang1Shuai Liu2Shuling Liu3Yuying Zhou4Jinhuan Wang5Li Cai6Shuo Gao7Yong Ji81Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin 300060, China 2Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300060, ChinaPET-CT Center, Tianjin Medical University General Hospital, Tianjin 300052, China1Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin 300060, China 2Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300060, China1Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin 300060, China 2Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300060, China1Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin 300060, China 2Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300060, China1Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin 300060, China 2Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, ChinaPET-CT Center, Tianjin Medical University General Hospital, Tianjin 300052, ChinaPET-CT Center, Tianjin Medical University General Hospital, Tianjin 300052, China1Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin 300060, China 2Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300060, China<p><strong>Objective</strong> The present study investigated the relationship between amyloid deposition and glucose metabolism using Pittsburgh compound B (<sup>11</sup>C-PIB) and fluorodeoxyglucose (<sup>18</sup>F-FDG) positron-emission tomography (PET) in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) and assessed the apolipoprotein E (<em>ApoE</em>) ε4 allele to explore the correlation between aMCI and AD. <strong>Methods</strong> Amyloid load in the brain and cerebral glucose metabolism were determined and <em>ApoE</em> genotypes were analyzed in patients with AD (N = 14), aMCI (N = 10), and healthy controls (N = 5). <strong>Results </strong>The mean <sup>11</sup>C-PIB standardized uptake value ratio (SUVR) was higher in inferior parietal lobe, lateral temporal cortex, frontal cortex, posterior cingulate cortex and precuneus, occipital lobe, and striatum in AD patients compared with controls (<em>P</em> < 0.05). <sup>11</sup>C-PIB binding levels in aMCI patients were bimodal. No significant difference in the <sup>11</sup>C-PIB SUVR was found between the <sup>11</sup>C-PIB + aMCI subgroup and AD group (<em>P</em> > 0.05). <sup>18</sup>F-FDG PET revealed hypometabolism in bilateral parietal lobes, temporal lobe, and precuneus in 3 of 5 <sup>11</sup>C-PIB + aMCI subjects, including two of them with <em>ApoE ε 4</em> allele converted to AD, and hypometabolism in the bilateral frontal lobe and anterior cingulate in 3 of 5 <sup>11</sup>C-PIB - aMCI subjects. <strong>Conclusions</strong> <sup>11</sup>C-PIB PET is a powerful tool for screening aMCI with AD pathology. The aMCI patients with AD pathology who presented hypometabolism in the parietal lobe, lateral temporal cortex, precuneus and with <em>ApoE ε 4</em> allele are more likely to convert to clinical AD dementia.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.03.013</p>http://www.cjcnn.org/index.php/cjcnn/article/view/915Alzheimer diseaseCognition disordersApolipoprotein E4Radioactive tracersPositron-emission tomography |
| spellingShingle | Zhihong Shi Ying Wang Shuai Liu Shuling Liu Yuying Zhou Jinhuan Wang Li Cai Shuo Gao Yong Ji 11C-PIB PET and 18F-FDG PET in patients with Alzheimer's disease and amnestic mild cognitive impairment Chinese Journal of Contemporary Neurology and Neurosurgery Alzheimer disease Cognition disorders Apolipoprotein E4 Radioactive tracers Positron-emission tomography |
| title | 11C-PIB PET and 18F-FDG PET in patients with Alzheimer's disease and amnestic mild cognitive impairment |
| title_full | 11C-PIB PET and 18F-FDG PET in patients with Alzheimer's disease and amnestic mild cognitive impairment |
| title_fullStr | 11C-PIB PET and 18F-FDG PET in patients with Alzheimer's disease and amnestic mild cognitive impairment |
| title_full_unstemmed | 11C-PIB PET and 18F-FDG PET in patients with Alzheimer's disease and amnestic mild cognitive impairment |
| title_short | 11C-PIB PET and 18F-FDG PET in patients with Alzheimer's disease and amnestic mild cognitive impairment |
| title_sort | 11c pib pet and 18f fdg pet in patients with alzheimer s disease and amnestic mild cognitive impairment |
| topic | Alzheimer disease Cognition disorders Apolipoprotein E4 Radioactive tracers Positron-emission tomography |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/915 |
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