Musculoskeletal Ultrasound in Monitoring Clinical Response to Treatment in Acute Symptomatic Psoriatic Dactylitis: Results from a Multicentre Prospective Observational Study
This observational and prospective study evaluated the clinical correlations of sonographic lesions in consecutive psoriatic arthritis (PsA) dactylitis cases. Eighty-three dactylitic digits were evaluated clinically and sonographically before treatment and at one-month (T1) and three-month (T3) foll...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/10/3127 |
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| author | Nicolò Girolimetto Pierluigi Macchioni Niccolò Possemato Ilaria Tinazzi Vittoria Bascherini Giorgia Citriniti Rebecca McConnell Antonio Marchetta Rosario Peluso Vincenzo Sabbatino Carlo Salvarani Raffaele Scarpa Luisa Costa Francesco Caso |
| author_facet | Nicolò Girolimetto Pierluigi Macchioni Niccolò Possemato Ilaria Tinazzi Vittoria Bascherini Giorgia Citriniti Rebecca McConnell Antonio Marchetta Rosario Peluso Vincenzo Sabbatino Carlo Salvarani Raffaele Scarpa Luisa Costa Francesco Caso |
| author_sort | Nicolò Girolimetto |
| collection | DOAJ |
| description | This observational and prospective study evaluated the clinical correlations of sonographic lesions in consecutive psoriatic arthritis (PsA) dactylitis cases. Eighty-three dactylitic digits were evaluated clinically and sonographically before treatment and at one-month (T1) and three-month (T3) follow-up. Clinical evaluation included the Leeds Dactylitis Index-basic (LDI-b) score and the visual analogue scales for pain (VAS-p) and functional impairment (VAS-FI). High-frequency ultrasound with grey scale (GS) and power Doppler (PD) assessed flexor tenosynovitis (FT), soft tissue oedema (STO), extensor tendon paratenonitis, and joint synovitis. There was a statistically significant correlation between the clinical parameters (VAS-p, VAS-FI, and LDI-b) and FT and STO at T1 and T3. We found statistically significant improvement in FT and STO for the cases with clinically meaningful treatment responses (<i>p</i> < 0.001). After a multiple conditional logistic regression analysis, the only variables that correlated with a T1 clinical response were the resolutions of PD FT (OR 15.66) and PD STO (OR 6.23), while the resolution of PD FT (OR 27.77) and of GS STO (OR 7.29) correlated with a T3 clinical response. The clinical improvements of active dactylitis are linked to the regression of sonographic evidence of extracapsular inflammation (particularly FT and STO). |
| first_indexed | 2024-03-10T16:00:02Z |
| format | Article |
| id | doaj.art-ab934ad8c7e84a42ae50270c6e784adf |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T16:00:02Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ab934ad8c7e84a42ae50270c6e784adf2023-11-20T15:20:07ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-01910312710.3390/jcm9103127Musculoskeletal Ultrasound in Monitoring Clinical Response to Treatment in Acute Symptomatic Psoriatic Dactylitis: Results from a Multicentre Prospective Observational StudyNicolò Girolimetto0Pierluigi Macchioni1Niccolò Possemato2Ilaria Tinazzi3Vittoria Bascherini4Giorgia Citriniti5Rebecca McConnell6Antonio Marchetta7Rosario Peluso8Vincenzo Sabbatino9Carlo Salvarani10Raffaele Scarpa11Luisa Costa12Francesco Caso13Department of Clinical and Experimental Medicine, Rheumatology Research Unit, University Federico II, 80138 Naples, ItalyDepartment of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyDepartment of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Rheumatology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar, ItalyDepartment of Clinical and Experimental Medicine, Rheumatology Research Unit, University Federico II, 80138 Naples, ItalyDepartment of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyNeurosciences Center, Bronson Health Group, Kalamazoo, MI 49007, USAUnit of Rheumatology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar, ItalyDepartment of Clinical and Experimental Medicine, Rheumatology Research Unit, University Federico II, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, Rheumatology Research Unit, University Federico II, 80138 Naples, ItalyDepartment of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyDepartment of Clinical and Experimental Medicine, Rheumatology Research Unit, University Federico II, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, Rheumatology Research Unit, University Federico II, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, Rheumatology Research Unit, University Federico II, 80138 Naples, ItalyThis observational and prospective study evaluated the clinical correlations of sonographic lesions in consecutive psoriatic arthritis (PsA) dactylitis cases. Eighty-three dactylitic digits were evaluated clinically and sonographically before treatment and at one-month (T1) and three-month (T3) follow-up. Clinical evaluation included the Leeds Dactylitis Index-basic (LDI-b) score and the visual analogue scales for pain (VAS-p) and functional impairment (VAS-FI). High-frequency ultrasound with grey scale (GS) and power Doppler (PD) assessed flexor tenosynovitis (FT), soft tissue oedema (STO), extensor tendon paratenonitis, and joint synovitis. There was a statistically significant correlation between the clinical parameters (VAS-p, VAS-FI, and LDI-b) and FT and STO at T1 and T3. We found statistically significant improvement in FT and STO for the cases with clinically meaningful treatment responses (<i>p</i> < 0.001). After a multiple conditional logistic regression analysis, the only variables that correlated with a T1 clinical response were the resolutions of PD FT (OR 15.66) and PD STO (OR 6.23), while the resolution of PD FT (OR 27.77) and of GS STO (OR 7.29) correlated with a T3 clinical response. The clinical improvements of active dactylitis are linked to the regression of sonographic evidence of extracapsular inflammation (particularly FT and STO).https://www.mdpi.com/2077-0383/9/10/3127dactylitispsoriatic arthritisultrasoundflexor tenosynovitissoft tissue odema |
| spellingShingle | Nicolò Girolimetto Pierluigi Macchioni Niccolò Possemato Ilaria Tinazzi Vittoria Bascherini Giorgia Citriniti Rebecca McConnell Antonio Marchetta Rosario Peluso Vincenzo Sabbatino Carlo Salvarani Raffaele Scarpa Luisa Costa Francesco Caso Musculoskeletal Ultrasound in Monitoring Clinical Response to Treatment in Acute Symptomatic Psoriatic Dactylitis: Results from a Multicentre Prospective Observational Study Journal of Clinical Medicine dactylitis psoriatic arthritis ultrasound flexor tenosynovitis soft tissue odema |
| title | Musculoskeletal Ultrasound in Monitoring Clinical Response to Treatment in Acute Symptomatic Psoriatic Dactylitis: Results from a Multicentre Prospective Observational Study |
| title_full | Musculoskeletal Ultrasound in Monitoring Clinical Response to Treatment in Acute Symptomatic Psoriatic Dactylitis: Results from a Multicentre Prospective Observational Study |
| title_fullStr | Musculoskeletal Ultrasound in Monitoring Clinical Response to Treatment in Acute Symptomatic Psoriatic Dactylitis: Results from a Multicentre Prospective Observational Study |
| title_full_unstemmed | Musculoskeletal Ultrasound in Monitoring Clinical Response to Treatment in Acute Symptomatic Psoriatic Dactylitis: Results from a Multicentre Prospective Observational Study |
| title_short | Musculoskeletal Ultrasound in Monitoring Clinical Response to Treatment in Acute Symptomatic Psoriatic Dactylitis: Results from a Multicentre Prospective Observational Study |
| title_sort | musculoskeletal ultrasound in monitoring clinical response to treatment in acute symptomatic psoriatic dactylitis results from a multicentre prospective observational study |
| topic | dactylitis psoriatic arthritis ultrasound flexor tenosynovitis soft tissue odema |
| url | https://www.mdpi.com/2077-0383/9/10/3127 |
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