Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks
In this work, novel copolymers of poly(adipic anhydride-co-mannitol) were synthesized by melting condensation polymerization of poly(adipic anhydride) with five percentages of mannitol sugar, 1 to 5 Wt.%. These copolymers were purified and then, characterized by FT-IR, which was proved that the cros...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2016-06-01
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| Series: | Baghdad Science Journal |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2767 |
| _version_ | 1819208401696063488 |
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| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | In this work, novel copolymers of poly(adipic anhydride-co-mannitol) were synthesized by melting condensation polymerization of poly(adipic anhydride) with five percentages of mannitol sugar, 1 to 5 Wt.%. These copolymers were purified and then, characterized by FT-IR, which was proved that the cross-linking reaction was caused by nucleophilic attack of mannitol hydroxyl group to acidic anhydride groups of poly(adipic anhydride) backbone and new ester groups were formed and appeared. Also, modified organic-soluble chitosan, N-maleoyl-chitosan, were synthesized by grafting reaction of chitosan with maleic anhydride in DMF as solvent, and it was also purified and characterized by FT-IR. Biodegradation in vitro of the IPNs of poly(adipic anhydride-co-mannitol)-N-maleoyl chitosan networks were evaluated by hydrolytic degradation studies at three different media (PBS, SIF and SGF) for 18 weeks with 92% as maximum degradation and it was found that minimum weight loss of IPNs was noticeably shown in SIF. In addition, hydrolytic degradation percent was decreased with increasing mannitol proportions. |
| first_indexed | 2024-12-23T05:38:48Z |
| format | Article |
| id | doaj.art-ab955d2ce2894d7e9047bc61f74e6e52 |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-12-23T05:38:48Z |
| publishDate | 2016-06-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-ab955d2ce2894d7e9047bc61f74e6e522022-12-21T17:58:15ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862016-06-0113210.21123/bsj.13.2.210-220Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan NetworksBaghdad Science JournalIn this work, novel copolymers of poly(adipic anhydride-co-mannitol) were synthesized by melting condensation polymerization of poly(adipic anhydride) with five percentages of mannitol sugar, 1 to 5 Wt.%. These copolymers were purified and then, characterized by FT-IR, which was proved that the cross-linking reaction was caused by nucleophilic attack of mannitol hydroxyl group to acidic anhydride groups of poly(adipic anhydride) backbone and new ester groups were formed and appeared. Also, modified organic-soluble chitosan, N-maleoyl-chitosan, were synthesized by grafting reaction of chitosan with maleic anhydride in DMF as solvent, and it was also purified and characterized by FT-IR. Biodegradation in vitro of the IPNs of poly(adipic anhydride-co-mannitol)-N-maleoyl chitosan networks were evaluated by hydrolytic degradation studies at three different media (PBS, SIF and SGF) for 18 weeks with 92% as maximum degradation and it was found that minimum weight loss of IPNs was noticeably shown in SIF. In addition, hydrolytic degradation percent was decreased with increasing mannitol proportions.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2767"melt condensation, poly(adipic anhydride), mannitol, poly(adipic anhydride-co-mannitol), biodegradable polymer, in vitro degradation " |
| spellingShingle | Baghdad Science Journal Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks Baghdad Science Journal "melt condensation, poly(adipic anhydride), mannitol, poly(adipic anhydride-co-mannitol), biodegradable polymer, in vitro degradation " |
| title | Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks |
| title_full | Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks |
| title_fullStr | Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks |
| title_full_unstemmed | Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks |
| title_short | Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks |
| title_sort | biodegradation studies in vitro of novel poly adipic anhydride co mannitol n maleoyl chitosan networks |
| topic | "melt condensation, poly(adipic anhydride), mannitol, poly(adipic anhydride-co-mannitol), biodegradable polymer, in vitro degradation " |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2767 |
| work_keys_str_mv | AT baghdadsciencejournal biodegradationstudiesinvitroofnovelpolyadipicanhydridecomannitolnmaleoylchitosannetworks |