Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer’s Disease

Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer’s Disease

Simufilam is a novel oral drug candidate in Phase 3 clinical trials for Alzheimer’s disease (AD) dementia. This small molecule binds an altered form of filamin A (FLNA) that occurs in AD. This drug action disrupts FLNA’s aberrant linkage to the α7 nicotinic acetylcholine receptor (α7nAChR), thereby...

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Bibliographic Details
Main Authors:	Hoau-Yan Wang, Erika Cecon, Julie Dam, Zhe Pei, Ralf Jockers, Lindsay H. Burns
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	International Journal of Molecular Sciences
Subjects:	α7 nicotinic acetylcholine receptor TLR4 TLR2 CXCR4 CD4 CCR5
Online Access:	https://www.mdpi.com/1422-0067/24/18/13927

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