Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing
Musculoskeletal health is paramount in an ageing population susceptible to conditions such as osteoporosis, arthritis and fractures. Age-related changes in bone, muscle, and joint function result in declining musculoskeletal health, reduced mobility, increased risk of falls, and persistent discomfor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1290721/full |
| _version_ | 1797397366819520512 |
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| author | Siti Liyana Saud Gany Kok-Yong Chin Jen Kit Tan Amilia Aminuddin Suzana Makpol |
| author_facet | Siti Liyana Saud Gany Kok-Yong Chin Jen Kit Tan Amilia Aminuddin Suzana Makpol |
| author_sort | Siti Liyana Saud Gany |
| collection | DOAJ |
| description | Musculoskeletal health is paramount in an ageing population susceptible to conditions such as osteoporosis, arthritis and fractures. Age-related changes in bone, muscle, and joint function result in declining musculoskeletal health, reduced mobility, increased risk of falls, and persistent discomfort. Preserving musculoskeletal wellbeing is essential for maintaining independence and enhancing the overall quality of life for the elderly. The global burden of musculoskeletal disorders is significant, impacting 1.71 billion individuals worldwide, with age-related muscle atrophy being a well-established phenomenon. Tocotrienols, a unique type of vitamin E found in various sources, demonstrate exceptional antioxidant capabilities compared to tocopherols. This characteristic positions them as promising candidates for addressing musculoskeletal challenges, particularly in mitigating inflammation and oxidative stress underlying musculoskeletal disorders. This review paper comprehensively examines existing research into the preventive and therapeutic potential of tocotrienols in addressing age-related musculoskeletal issues. It sheds light on the promising role of tocotrienols in enhancing musculoskeletal health and overall wellbeing, emphasizing their significance within the broader context of age-related health concerns. |
| first_indexed | 2024-03-09T01:08:51Z |
| format | Article |
| id | doaj.art-ab961087b8a3487bb86afaa2e52c9bb2 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T01:08:51Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ab961087b8a3487bb86afaa2e52c9bb22023-12-11T09:07:15ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.12907211290721Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageingSiti Liyana Saud Gany0Kok-Yong Chin1Jen Kit Tan2Amilia Aminuddin3Suzana Makpol4Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaMusculoskeletal health is paramount in an ageing population susceptible to conditions such as osteoporosis, arthritis and fractures. Age-related changes in bone, muscle, and joint function result in declining musculoskeletal health, reduced mobility, increased risk of falls, and persistent discomfort. Preserving musculoskeletal wellbeing is essential for maintaining independence and enhancing the overall quality of life for the elderly. The global burden of musculoskeletal disorders is significant, impacting 1.71 billion individuals worldwide, with age-related muscle atrophy being a well-established phenomenon. Tocotrienols, a unique type of vitamin E found in various sources, demonstrate exceptional antioxidant capabilities compared to tocopherols. This characteristic positions them as promising candidates for addressing musculoskeletal challenges, particularly in mitigating inflammation and oxidative stress underlying musculoskeletal disorders. This review paper comprehensively examines existing research into the preventive and therapeutic potential of tocotrienols in addressing age-related musculoskeletal issues. It sheds light on the promising role of tocotrienols in enhancing musculoskeletal health and overall wellbeing, emphasizing their significance within the broader context of age-related health concerns.https://www.frontiersin.org/articles/10.3389/fphar.2023.1290721/fullmusculoskeletalageingtocotrienolmuscle ageingsarcopeniaosteoporosis |
| spellingShingle | Siti Liyana Saud Gany Kok-Yong Chin Jen Kit Tan Amilia Aminuddin Suzana Makpol Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing Frontiers in Pharmacology musculoskeletal ageing tocotrienol muscle ageing sarcopenia osteoporosis |
| title | Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing |
| title_full | Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing |
| title_fullStr | Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing |
| title_full_unstemmed | Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing |
| title_short | Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing |
| title_sort | preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing |
| topic | musculoskeletal ageing tocotrienol muscle ageing sarcopenia osteoporosis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1290721/full |
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