Structural Plasticity Is a Feature of Rheostat Positions in the Human Na<sup>+</sup>/Taurocholate Cotransporting Polypeptide (NTCP)

Structural Plasticity Is a Feature of Rheostat Positions in the Human Na<sup>+</sup>/Taurocholate Cotransporting Polypeptide (NTCP)

In the Na<sup>+</sup>/taurocholate cotransporting polypeptide (NTCP), the clinically relevant S267F polymorphism occurs at a “rheostat position”. That is, amino acid substitutions at this position (“S267X”) lead to a wide range of functional outcomes. This result was particularly strikin...

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Bibliographic Details
Main Authors: Melissa J. Ruggiero, Shipra Malhotra, Aron W. Fenton, Liskin Swint-Kruse, John Karanicolas, Bruno Hagenbuch
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
rheostat
transmembrane protein
protein plasticity
Online Access:https://www.mdpi.com/1422-0067/23/6/3211

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