Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice
Zhenguo Cai,1,2,* Yibin Zeng,3,* Zhuohang Liu,3 Ruizheng Zhu,3 Wuqing Wang1,3 1Department of Dermatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Department of Dermatology, Changhai Hospital, Naval Medical...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-09-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/curcumin-alleviates-epidermal-psoriasis-like-dermatitis-and-il-6stat3--peer-reviewed-fulltext-article-CCID |
| _version_ | 1797694057081733120 |
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| author | Cai Z Zeng Y Liu Z Zhu R Wang W |
| author_facet | Cai Z Zeng Y Liu Z Zhu R Wang W |
| author_sort | Cai Z |
| collection | DOAJ |
| description | Zhenguo Cai,1,2,* Yibin Zeng,3,* Zhuohang Liu,3 Ruizheng Zhu,3 Wuqing Wang1,3 1Department of Dermatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China; 3Department of Dermatology, Minhang Hospital, Fudan University/Central Hospital of Minhang District, Shanghai, 201199, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wuqing Wang; Ruizheng Zhu, Email wangwuqing121@sina.com; bigbigworld_emilia@163.comBackground: To further investigate why curcumin (CUR) can attenuate psoriasis-like dermatitis of mice.Methods and Results: Sixteen mice were randomized into four groups. The control group used carrier cream, and the model and the CUR group were applied with topical 5% imiquimod in the naked mice skin once a day for 6 days (62.5 mg/day/mice). Meanwhile, the control and model mice were given the same dose of saline by oral means, while mice in the CUR groups received oral drug doses of 50 and 100 mg/kg once a day for 6 days, respectively. CUR could largely improve imiquimod-induced lesions of mice. By using the ELISA and qPCR, we found that the protein and mRNA levels of epidermal TNF-α and IL-6 were inhibited by CUR. The phosphorylation levels of STAT3 and its downstream associated protein levels (eg, Cyclin D1, Bcl-2 and Pim1) in skin tissues of different groups were also inhibited by CUR. Furthermore, the results of immunohistochemistry also showed the repressed effect of CUR for the expression of TNF-α, IL-6 and p-STAT3 in psoriasis-like lesions of mice.Conclusion: CUR can effectively ameliorate the featured lesions of psoriasis mice, which may be closely associated with the involvement of IL-6/STAT3 signaling.Keywords: curcumin, psoriasis, IL-6/STAT3, inflammation |
| first_indexed | 2024-03-12T02:52:28Z |
| format | Article |
| id | doaj.art-ab970829a92f46ffb5188ae0265dd579 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-03-12T02:52:28Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-ab970829a92f46ffb5188ae0265dd5792023-09-03T19:02:41ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152023-09-01Volume 162399240886360Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of MiceCai ZZeng YLiu ZZhu RWang WZhenguo Cai,1,2,* Yibin Zeng,3,* Zhuohang Liu,3 Ruizheng Zhu,3 Wuqing Wang1,3 1Department of Dermatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China; 3Department of Dermatology, Minhang Hospital, Fudan University/Central Hospital of Minhang District, Shanghai, 201199, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wuqing Wang; Ruizheng Zhu, Email wangwuqing121@sina.com; bigbigworld_emilia@163.comBackground: To further investigate why curcumin (CUR) can attenuate psoriasis-like dermatitis of mice.Methods and Results: Sixteen mice were randomized into four groups. The control group used carrier cream, and the model and the CUR group were applied with topical 5% imiquimod in the naked mice skin once a day for 6 days (62.5 mg/day/mice). Meanwhile, the control and model mice were given the same dose of saline by oral means, while mice in the CUR groups received oral drug doses of 50 and 100 mg/kg once a day for 6 days, respectively. CUR could largely improve imiquimod-induced lesions of mice. By using the ELISA and qPCR, we found that the protein and mRNA levels of epidermal TNF-α and IL-6 were inhibited by CUR. The phosphorylation levels of STAT3 and its downstream associated protein levels (eg, Cyclin D1, Bcl-2 and Pim1) in skin tissues of different groups were also inhibited by CUR. Furthermore, the results of immunohistochemistry also showed the repressed effect of CUR for the expression of TNF-α, IL-6 and p-STAT3 in psoriasis-like lesions of mice.Conclusion: CUR can effectively ameliorate the featured lesions of psoriasis mice, which may be closely associated with the involvement of IL-6/STAT3 signaling.Keywords: curcumin, psoriasis, IL-6/STAT3, inflammationhttps://www.dovepress.com/curcumin-alleviates-epidermal-psoriasis-like-dermatitis-and-il-6stat3--peer-reviewed-fulltext-article-CCIDcurcuminpsoriasisil-6/stat3inflammation |
| spellingShingle | Cai Z Zeng Y Liu Z Zhu R Wang W Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice Clinical, Cosmetic and Investigational Dermatology curcumin psoriasis il-6/stat3 inflammation |
| title | Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice |
| title_full | Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice |
| title_fullStr | Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice |
| title_full_unstemmed | Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice |
| title_short | Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice |
| title_sort | curcumin alleviates epidermal psoriasis like dermatitis and il 6 stat3 pathway of mice |
| topic | curcumin psoriasis il-6/stat3 inflammation |
| url | https://www.dovepress.com/curcumin-alleviates-epidermal-psoriasis-like-dermatitis-and-il-6stat3--peer-reviewed-fulltext-article-CCID |
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