Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients
Tianjun Wei,1,2 Wei Wei,2 Qiang Ma,2 Zhongbing Shen,2 Kebing Lu,2 Xiangming Zhu1,2 1School of Continuing Education, Anhui Medical University, Hefei, 230032, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241001, People’s Republic...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-08-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/development-of-a-clinical-radiomics-nomogram-that-used-contrast-enhanc-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1797733356095406080 |
|---|---|
| author | Wei T Wei W Ma Q Shen Z Lu K Zhu X |
| author_facet | Wei T Wei W Ma Q Shen Z Lu K Zhu X |
| author_sort | Wei T |
| collection | DOAJ |
| description | Tianjun Wei,1,2 Wei Wei,2 Qiang Ma,2 Zhongbing Shen,2 Kebing Lu,2 Xiangming Zhu1,2 1School of Continuing Education, Anhui Medical University, Hefei, 230032, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241001, People’s Republic of ChinaCorrespondence: Xiangming Zhu, School of Continuing Education, Anhui Medical University, NO. 81 Meishan Road, Shushan District, Hefei City, Anhui Province, 230032, People’s Republic of China, Tel +86 553-5739808, Email xiangmingzhudr@yeah.netBackground and Objectives: Papillary thyroid carcinoma (PTC) is a prevalent histological type of thyroid cancer; however, noninvasive assessment of cervical lymph node metastasis (LNM) poses a challenge. This study aims to develop a novel clinical-radiomics nomogram that utilizes ultrasound (US) images to predict the presence of cervical LNM metastasis in patients with PTC.Methods: A total of 423 patients with PTC were recruited to participate in this study between January 2020 and December 2022, of which 282 were classified into the training group and 141 patients were classified into the validation set. Contrast-enhanced ultrasound (CEUS) and B-mode ultrasound (BMUS) images were subjected to radiomic analysis, leading to the extraction of 912 radiomic features. Thereafter, a radiomics score (Radscore) was developed to effectively integrate the information derived from BMUS and CEUS modalities. Univariate and multivariate backward stepwise logistic regression analysis techniques were used to construct the clinical and clinical-radiomics models, respectively.Results: The findings revealed that the clinical-radiomics nomogram incorporated age, sex, CEUS Radscore, and US-reported LNM as risk factors. The nomogram demonstrated good performance using data from the training (AUC = 0.891) and validation (AUC = 0.870) sets. The decision curve analysis implied that this nomogram exhibited good clinical utility, which was further supported by the results of the calibration curves and Hosmer-Lemeshow test.Conclusion: The CEUS Radscore-based clinical radiomics nomogram could serve as a valuable tool for predicting cervical LNM metastasis in patients with PTC, thereby tailoring individualized treatment strategies for them.Keywords: lymph node metastasis, radiomics, papillary thyroid carcinoma, contrast-enhanced ultrasound, B-mode ultrasound |
| first_indexed | 2024-03-12T12:28:00Z |
| format | Article |
| id | doaj.art-ab9827cc9aaa42779c8b046ea94210eb |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-03-12T12:28:00Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-ab9827cc9aaa42779c8b046ea94210eb2023-08-29T19:31:00ZengDove Medical PressInternational Journal of General Medicine1178-70742023-08-01Volume 163921393286269Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma PatientsWei TWei WMa QShen ZLu KZhu XTianjun Wei,1,2 Wei Wei,2 Qiang Ma,2 Zhongbing Shen,2 Kebing Lu,2 Xiangming Zhu1,2 1School of Continuing Education, Anhui Medical University, Hefei, 230032, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241001, People’s Republic of ChinaCorrespondence: Xiangming Zhu, School of Continuing Education, Anhui Medical University, NO. 81 Meishan Road, Shushan District, Hefei City, Anhui Province, 230032, People’s Republic of China, Tel +86 553-5739808, Email xiangmingzhudr@yeah.netBackground and Objectives: Papillary thyroid carcinoma (PTC) is a prevalent histological type of thyroid cancer; however, noninvasive assessment of cervical lymph node metastasis (LNM) poses a challenge. This study aims to develop a novel clinical-radiomics nomogram that utilizes ultrasound (US) images to predict the presence of cervical LNM metastasis in patients with PTC.Methods: A total of 423 patients with PTC were recruited to participate in this study between January 2020 and December 2022, of which 282 were classified into the training group and 141 patients were classified into the validation set. Contrast-enhanced ultrasound (CEUS) and B-mode ultrasound (BMUS) images were subjected to radiomic analysis, leading to the extraction of 912 radiomic features. Thereafter, a radiomics score (Radscore) was developed to effectively integrate the information derived from BMUS and CEUS modalities. Univariate and multivariate backward stepwise logistic regression analysis techniques were used to construct the clinical and clinical-radiomics models, respectively.Results: The findings revealed that the clinical-radiomics nomogram incorporated age, sex, CEUS Radscore, and US-reported LNM as risk factors. The nomogram demonstrated good performance using data from the training (AUC = 0.891) and validation (AUC = 0.870) sets. The decision curve analysis implied that this nomogram exhibited good clinical utility, which was further supported by the results of the calibration curves and Hosmer-Lemeshow test.Conclusion: The CEUS Radscore-based clinical radiomics nomogram could serve as a valuable tool for predicting cervical LNM metastasis in patients with PTC, thereby tailoring individualized treatment strategies for them.Keywords: lymph node metastasis, radiomics, papillary thyroid carcinoma, contrast-enhanced ultrasound, B-mode ultrasoundhttps://www.dovepress.com/development-of-a-clinical-radiomics-nomogram-that-used-contrast-enhanc-peer-reviewed-fulltext-article-IJGMlymph node metastasisradiomicspapillary thyroid carcinomacontrast-enhanced ultrasoundb-mode ultrasound. |
| spellingShingle | Wei T Wei W Ma Q Shen Z Lu K Zhu X Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients International Journal of General Medicine lymph node metastasis radiomics papillary thyroid carcinoma contrast-enhanced ultrasound b-mode ultrasound. |
| title | Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients |
| title_full | Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients |
| title_fullStr | Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients |
| title_full_unstemmed | Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients |
| title_short | Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients |
| title_sort | development of a clinical radiomics nomogram that used contrast enhanced ultrasound images to anticipate the occurrence of preoperative cervical lymph node metastasis in papillary thyroid carcinoma patients |
| topic | lymph node metastasis radiomics papillary thyroid carcinoma contrast-enhanced ultrasound b-mode ultrasound. |
| url | https://www.dovepress.com/development-of-a-clinical-radiomics-nomogram-that-used-contrast-enhanc-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT weit developmentofaclinicalradiomicsnomogramthatusedcontrastenhancedultrasoundimagestoanticipatetheoccurrenceofpreoperativecervicallymphnodemetastasisinpapillarythyroidcarcinomapatients AT weiw developmentofaclinicalradiomicsnomogramthatusedcontrastenhancedultrasoundimagestoanticipatetheoccurrenceofpreoperativecervicallymphnodemetastasisinpapillarythyroidcarcinomapatients AT maq developmentofaclinicalradiomicsnomogramthatusedcontrastenhancedultrasoundimagestoanticipatetheoccurrenceofpreoperativecervicallymphnodemetastasisinpapillarythyroidcarcinomapatients AT shenz developmentofaclinicalradiomicsnomogramthatusedcontrastenhancedultrasoundimagestoanticipatetheoccurrenceofpreoperativecervicallymphnodemetastasisinpapillarythyroidcarcinomapatients AT luk developmentofaclinicalradiomicsnomogramthatusedcontrastenhancedultrasoundimagestoanticipatetheoccurrenceofpreoperativecervicallymphnodemetastasisinpapillarythyroidcarcinomapatients AT zhux developmentofaclinicalradiomicsnomogramthatusedcontrastenhancedultrasoundimagestoanticipatetheoccurrenceofpreoperativecervicallymphnodemetastasisinpapillarythyroidcarcinomapatients |