Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database.
INTRODUCTION:Brain tumors are the most common solid malignancy and leading cause of cancer-related deaths in infants. Current epidemiological data is limited by low numbers of reported cases. This study used a population-based approach with analysis of contemporary and historical survival curves to...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0223051 |
| _version_ | 1818678539095900160 |
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| author | Claire Faltermeier Timothy Chai Sharjeel Syed Nathan Lau Lior Elkaim George Ibrahim Anthony Wang Alexander Weil Anne Bendel Aria Fallah Albert Tu |
| author_facet | Claire Faltermeier Timothy Chai Sharjeel Syed Nathan Lau Lior Elkaim George Ibrahim Anthony Wang Alexander Weil Anne Bendel Aria Fallah Albert Tu |
| author_sort | Claire Faltermeier |
| collection | DOAJ |
| description | INTRODUCTION:Brain tumors are the most common solid malignancy and leading cause of cancer-related deaths in infants. Current epidemiological data is limited by low numbers of reported cases. This study used a population-based approach with analysis of contemporary and historical survival curves to provide up-to-date prognostication. METHODS:Observational cohort analysis was performed using the Surveillance, Epidemiology and End Results (SEER) database. Infants with brain tumors diagnosed from 1973 to 2013 were categorized by the most common tumor types (diffuse astrocytic and oligodendroglioma, choroid plexus, embryonal, ependymal, medulloblastoma and pilocytic astrocytoma). The 1, 5 and 10 year survival was stratified by decade, with trends in management and outcomes analyzed. RESULTS:We identified 2996 affected infants satisfying inclusion criteria. All tumor types, except embryonal and choroid plexus, demonstrated improving survival with time. Infants with embryonal tumors showed a decline in survival from the 1970s to 1990s (p = 0.009), whereas infants with choroid plexus tumors had no change in survival. Infants with ependymal tumors experienced the greatest improvement in survival from 1980s to 1990s and 1990s to 2000s (p = 0.0001, p = 0.01), with 5-year survival probability improving from 28% (95% CI 15-42%) in the 1980s to 77% (95% CI 69-83%) the 2000s. The use of radiation declined from 1970 to 2000 for all tumors; however, radiation treatment for embryonal and ependymal subtypes increased after 2000. CONCLUSIONS:While overall survival for infants with brain tumors has improved from the 1970s onwards, not every tumor type has seen a statistically significant change. Given changes in management and survival, prognostication of infants with brain tumor should be updated. |
| first_indexed | 2024-12-17T09:16:52Z |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T09:16:52Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-ab9acb5e18834ca797afb38cb5f58f352022-12-21T21:54:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01149e022305110.1371/journal.pone.0223051Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database.Claire FaltermeierTimothy ChaiSharjeel SyedNathan LauLior ElkaimGeorge IbrahimAnthony WangAlexander WeilAnne BendelAria FallahAlbert TuINTRODUCTION:Brain tumors are the most common solid malignancy and leading cause of cancer-related deaths in infants. Current epidemiological data is limited by low numbers of reported cases. This study used a population-based approach with analysis of contemporary and historical survival curves to provide up-to-date prognostication. METHODS:Observational cohort analysis was performed using the Surveillance, Epidemiology and End Results (SEER) database. Infants with brain tumors diagnosed from 1973 to 2013 were categorized by the most common tumor types (diffuse astrocytic and oligodendroglioma, choroid plexus, embryonal, ependymal, medulloblastoma and pilocytic astrocytoma). The 1, 5 and 10 year survival was stratified by decade, with trends in management and outcomes analyzed. RESULTS:We identified 2996 affected infants satisfying inclusion criteria. All tumor types, except embryonal and choroid plexus, demonstrated improving survival with time. Infants with embryonal tumors showed a decline in survival from the 1970s to 1990s (p = 0.009), whereas infants with choroid plexus tumors had no change in survival. Infants with ependymal tumors experienced the greatest improvement in survival from 1980s to 1990s and 1990s to 2000s (p = 0.0001, p = 0.01), with 5-year survival probability improving from 28% (95% CI 15-42%) in the 1980s to 77% (95% CI 69-83%) the 2000s. The use of radiation declined from 1970 to 2000 for all tumors; however, radiation treatment for embryonal and ependymal subtypes increased after 2000. CONCLUSIONS:While overall survival for infants with brain tumors has improved from the 1970s onwards, not every tumor type has seen a statistically significant change. Given changes in management and survival, prognostication of infants with brain tumor should be updated.https://doi.org/10.1371/journal.pone.0223051 |
| spellingShingle | Claire Faltermeier Timothy Chai Sharjeel Syed Nathan Lau Lior Elkaim George Ibrahim Anthony Wang Alexander Weil Anne Bendel Aria Fallah Albert Tu Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database. PLoS ONE |
| title | Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database. |
| title_full | Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database. |
| title_fullStr | Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database. |
| title_full_unstemmed | Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database. |
| title_short | Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database. |
| title_sort | survival of infants ≤24 months of age with brain tumors a population based study using the seer database |
| url | https://doi.org/10.1371/journal.pone.0223051 |
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