Production, characterization and toxicology assay of creatine pegylated nanoliposome with polysorbate 80 for brain delivery

Production, characterization and toxicology assay of creatine pegylated nanoliposome with polysorbate 80 for brain delivery

ABSTRACT Creatine acts intracellularly as energy buffer and storage, demonstrating protective effects in animal models of neurodegenerative diseases. However, its permeability throught blood-brain barrier (BBB) is reduced. The aim of the present study was developing a carrier to facilitate the deliv...

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Main Authors: DIEGO B. BORIN, NATHANA J. MEZZOMO, RODRIGO A. VAUCHER, GUILHERME DO CARMO, LUIZ C. RODRIGUES JUNIOR, FERNANDO B. SULCZEWSKI, CLAITON I. SCHWERTZ, RICARDO E. MENDES, ADRIANI P. DAMIANI, VANESSA M. DE ANDRADE, VIRGÍNIA C. RECH, CARINA R. BOECK
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2018-04-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
nanocarrier
neurodegenerative diseases
nanotechnology
liposomes
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018005007105&lng=en&tlng=en

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