Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia

Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia

Objective: To observe the antioxidative effects of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors (NAY) in vitro and in vivo models of hyperuricemia and explore the mechanism.Methods: A classical experimental method of acute toxicity and a chronic toxicity test were used to compare...

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Bibliographic Details
Main Authors: Tianshu Gao, Jin Xu, Yuxiao Xiao, Jiaqi Li, Weifeng Hu, Xiaoyu Su, Xudong Shen, Wan Yu, Zhen Chen, Baosheng Huang, Honglei Li, Xing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
anthraquinone
hyperuricemia
xanthine oxidase inhibitor
uric acid transporter
mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.950699/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.950699/full

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