Structure-Based Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities

Structure-Based Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities

Phosphodiesterase 10 is a promising target for the treatment of a series of central nervous system (CNS) diseases. Imbalance between oxidative stress and antioxidant defense systems as a universal condition in neurodegenerative disorders is widely studied as a potential therapy for CNS diseases, suc...

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Bibliographic Details
Main Authors:	Jinxuan Li, Jing-Yi Chen, Ya-Lin Deng, Qian Zhou, Yinuo Wu, Deyan Wu, Hai-Bin Luo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Series:	Frontiers in Chemistry
Subjects:	Phosphodiesterase-10A papaverine antioxidant activity Alzheimer's disease molecular docking
Online Access:	http://journal.frontiersin.org/article/10.3389/fchem.2018.00167/full

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