Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging
The cumulative damage skin sustains from exposure to environmental stressors throughout life exerts significant effects on skin aging and cancer development. One of the main ways by which environmental stressors mediate their effects within skin is through induction of reactive oxygen species (ROS)....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/6/1168 |
| _version_ | 1797596408375672832 |
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| author | Thomas A. Meyer William R. Swindell Ratan K. Chaudhuri |
| author_facet | Thomas A. Meyer William R. Swindell Ratan K. Chaudhuri |
| author_sort | Thomas A. Meyer |
| collection | DOAJ |
| description | The cumulative damage skin sustains from exposure to environmental stressors throughout life exerts significant effects on skin aging and cancer development. One of the main ways by which environmental stressors mediate their effects within skin is through induction of reactive oxygen species (ROS). In this review, we chronicle the multiple properties by which acetyl zingerone (AZ) as a skincare ingredient can benefit skin (1) by helping manage overproduction of ROS through multiple routes as an antioxidant, physical quencher and selective chelator, (2) by fortifying protection after UV exposure ends to prevent the type of epidermal DNA damage that correlates with development of skin cancer, (3) by modulating matrisome activity and nurturing the integrity of the extracellular matrix (ECM) within the dermis and (4) through its proficient ability to neutralize singlet oxygen, by stabilizing the ascorbic acid precursor tetrahexyldecyl ascorbate (THDC) in the dermal microenvironment. This activity improves THDC bioavailability and may blunt pro-inflammatory effects of THDC, such as activation of type I interferon signaling. Moreover, AZ is photostable and can sustain its properties during UV exposure, in contrast to α-tocopherol. All these properties of AZ translate into measurable clinical benefits to improve the visual appearance of photoaged facial skin and to strengthen the skin’s own defenses against sun damage. |
| first_indexed | 2024-03-11T02:49:59Z |
| format | Article |
| id | doaj.art-ab9dcf4cac504cf58f35e4af25dff506 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T02:49:59Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ab9dcf4cac504cf58f35e4af25dff5062023-11-18T09:02:24ZengMDPI AGAntioxidants2076-39212023-05-01126116810.3390/antiox12061168Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin AgingThomas A. Meyer0William R. Swindell1Ratan K. Chaudhuri2Sytheon, 10 Waterview Blvd, Parsippany, NJ 07054, USADepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USASytheon, 10 Waterview Blvd, Parsippany, NJ 07054, USAThe cumulative damage skin sustains from exposure to environmental stressors throughout life exerts significant effects on skin aging and cancer development. One of the main ways by which environmental stressors mediate their effects within skin is through induction of reactive oxygen species (ROS). In this review, we chronicle the multiple properties by which acetyl zingerone (AZ) as a skincare ingredient can benefit skin (1) by helping manage overproduction of ROS through multiple routes as an antioxidant, physical quencher and selective chelator, (2) by fortifying protection after UV exposure ends to prevent the type of epidermal DNA damage that correlates with development of skin cancer, (3) by modulating matrisome activity and nurturing the integrity of the extracellular matrix (ECM) within the dermis and (4) through its proficient ability to neutralize singlet oxygen, by stabilizing the ascorbic acid precursor tetrahexyldecyl ascorbate (THDC) in the dermal microenvironment. This activity improves THDC bioavailability and may blunt pro-inflammatory effects of THDC, such as activation of type I interferon signaling. Moreover, AZ is photostable and can sustain its properties during UV exposure, in contrast to α-tocopherol. All these properties of AZ translate into measurable clinical benefits to improve the visual appearance of photoaged facial skin and to strengthen the skin’s own defenses against sun damage.https://www.mdpi.com/2076-3921/12/6/1168acetyl zingeronenon-sacrificial antioxidantanti-inflammatoryselective chelatorincident and delayed CPDsmatrisome modulator |
| spellingShingle | Thomas A. Meyer William R. Swindell Ratan K. Chaudhuri Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging Antioxidants acetyl zingerone non-sacrificial antioxidant anti-inflammatory selective chelator incident and delayed CPDs matrisome modulator |
| title | Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging |
| title_full | Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging |
| title_fullStr | Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging |
| title_full_unstemmed | Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging |
| title_short | Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging |
| title_sort | acetyl zingerone a photostable multifunctional skincare ingredient that combats features of intrinsic and extrinsic skin aging |
| topic | acetyl zingerone non-sacrificial antioxidant anti-inflammatory selective chelator incident and delayed CPDs matrisome modulator |
| url | https://www.mdpi.com/2076-3921/12/6/1168 |
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