Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland
Various types of genetic variation contribute to the etiology of intellectual disability (ID). Here, the authors study a cohort of ID patients enriched for mild ID from Finland, to investigate contributions of rare and common variants associated with ID of different levels of severity.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-08262-y |
| _version_ | 1818751367616921600 |
|---|---|
| author | Mitja I. Kurki Elmo Saarentaus Olli Pietiläinen Padhraig Gormley Dennis Lal Sini Kerminen Minna Torniainen-Holm Eija Hämäläinen Elisa Rahikkala Riikka Keski-Filppula Merja Rauhala Satu Korpi-Heikkilä Jonna Komulainen–Ebrahim Heli Helander Päivi Vieira Minna Männikkö Markku Peltonen Aki S. Havulinna Veikko Salomaa Matti Pirinen Jaana Suvisaari Jukka S. Moilanen Jarmo Körkkö Outi Kuismin Mark J. Daly Aarno Palotie |
| author_facet | Mitja I. Kurki Elmo Saarentaus Olli Pietiläinen Padhraig Gormley Dennis Lal Sini Kerminen Minna Torniainen-Holm Eija Hämäläinen Elisa Rahikkala Riikka Keski-Filppula Merja Rauhala Satu Korpi-Heikkilä Jonna Komulainen–Ebrahim Heli Helander Päivi Vieira Minna Männikkö Markku Peltonen Aki S. Havulinna Veikko Salomaa Matti Pirinen Jaana Suvisaari Jukka S. Moilanen Jarmo Körkkö Outi Kuismin Mark J. Daly Aarno Palotie |
| author_sort | Mitja I. Kurki |
| collection | DOAJ |
| description | Various types of genetic variation contribute to the etiology of intellectual disability (ID). Here, the authors study a cohort of ID patients enriched for mild ID from Finland, to investigate contributions of rare and common variants associated with ID of different levels of severity. |
| first_indexed | 2024-12-18T04:34:27Z |
| format | Article |
| id | doaj.art-ab9e0271d0224acca582195c7d5d71d8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:34:27Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ab9e0271d0224acca582195c7d5d71d82022-12-21T21:20:54ZengNature PortfolioNature Communications2041-17232019-01-0110111510.1038/s41467-018-08262-yContribution of rare and common variants to intellectual disability in a sub-isolate of Northern FinlandMitja I. Kurki0Elmo Saarentaus1Olli Pietiläinen2Padhraig Gormley3Dennis Lal4Sini Kerminen5Minna Torniainen-Holm6Eija Hämäläinen7Elisa Rahikkala8Riikka Keski-Filppula9Merja Rauhala10Satu Korpi-Heikkilä11Jonna Komulainen–Ebrahim12Heli Helander13Päivi Vieira14Minna Männikkö15Markku Peltonen16Aki S. Havulinna17Veikko Salomaa18Matti Pirinen19Jaana Suvisaari20Jukka S. Moilanen21Jarmo Körkkö22Outi Kuismin23Mark J. Daly24Aarno Palotie25Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and HarvardPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiPEDEGO Research Unit, University of OuluPEDEGO Research Unit, University of OuluNorthern Ostrobothnia Hospital District, Center for Intellectual Disability CareNorthern Ostrobothnia Hospital District, Center for Intellectual Disability CareDepartment of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of OuluDepartment of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of OuluDepartment of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of OuluCenter for Life Course Health Research, Faculty of Medicine, University of OuluNational Institute for Health and WelfareInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiNational Institute for Health and WelfareInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiNational Institute for Health and WelfarePEDEGO Research Unit, University of OuluNorthern Ostrobothnia Hospital District, Center for Intellectual Disability CareInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonVarious types of genetic variation contribute to the etiology of intellectual disability (ID). Here, the authors study a cohort of ID patients enriched for mild ID from Finland, to investigate contributions of rare and common variants associated with ID of different levels of severity.https://doi.org/10.1038/s41467-018-08262-y |
| spellingShingle | Mitja I. Kurki Elmo Saarentaus Olli Pietiläinen Padhraig Gormley Dennis Lal Sini Kerminen Minna Torniainen-Holm Eija Hämäläinen Elisa Rahikkala Riikka Keski-Filppula Merja Rauhala Satu Korpi-Heikkilä Jonna Komulainen–Ebrahim Heli Helander Päivi Vieira Minna Männikkö Markku Peltonen Aki S. Havulinna Veikko Salomaa Matti Pirinen Jaana Suvisaari Jukka S. Moilanen Jarmo Körkkö Outi Kuismin Mark J. Daly Aarno Palotie Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland Nature Communications |
| title | Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland |
| title_full | Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland |
| title_fullStr | Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland |
| title_full_unstemmed | Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland |
| title_short | Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland |
| title_sort | contribution of rare and common variants to intellectual disability in a sub isolate of northern finland |
| url | https://doi.org/10.1038/s41467-018-08262-y |
| work_keys_str_mv | AT mitjaikurki contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT elmosaarentaus contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT ollipietilainen contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT padhraiggormley contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT dennislal contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT sinikerminen contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT minnatorniainenholm contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT eijahamalainen contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT elisarahikkala contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT riikkakeskifilppula contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT merjarauhala contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT satukorpiheikkila contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT jonnakomulainenebrahim contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT helihelander contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT paivivieira contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT minnamannikko contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT markkupeltonen contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT akishavulinna contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT veikkosalomaa contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT mattipirinen contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT jaanasuvisaari contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT jukkasmoilanen contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT jarmokorkko contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT outikuismin contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT markjdaly contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland AT aarnopalotie contributionofrareandcommonvariantstointellectualdisabilityinasubisolateofnorthernfinland |