Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy
Purpose: Cancer is an example of the most important growing diseases in human society and scientists are trying to treat it without considerable side effects on patient’s health. Solid lipids are colloidal nanoparticles that were used in drug delivery due to their several advantages. Methods: In thi...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2021-01-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-11-96.pdf |
| _version_ | 1818913966114471936 |
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| author | Parvaneh Bayat Parvaneh Pakravan Mojtaba Salouti Jafar Ezzati Nazhad Dolatabadi |
| author_facet | Parvaneh Bayat Parvaneh Pakravan Mojtaba Salouti Jafar Ezzati Nazhad Dolatabadi |
| author_sort | Parvaneh Bayat |
| collection | DOAJ |
| description | Purpose: Cancer is an example of the most important growing diseases in human society and scientists are trying to treat it without considerable side effects on patient’s health. Solid lipids are colloidal nanoparticles that were used in drug delivery due to their several advantages. Methods: In this work, surface modified targeted solid lipid nanoparticles (SLNs) were fabricated by nano-homogenizer using tripalmitin glyceride and stearic acid as lipid constituents. The size of nanoparticles and morphological evaluations were surveyed using particle size analyzer, scanning electron microscopy; Fourier transforms infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Results: The particle size of 148.5 and appropriate polydispersity index were achieved for lipid nanoparticles with an entrapment efficiency of 86.1%. The FT-IR analysis confirmed the coupling of lysine to the free functional group of SLNs. DSC proved the conjugation of amino acid to the surface of carriers. The in vitro epirubicin (EPI) release test exhibited the further controlled release phenomenon for the lysine conjugated nanoparticles. The cytotoxicity assay showed lower IC50 of lysine conjugated SLNs of EPI on the investigated cell line. Conclusion: These studies showed that the fabricated targeted carrier has a very remarkable anticancer effect on breast cancer cell lines in comparison with pure drug. |
| first_indexed | 2024-12-19T23:38:53Z |
| format | Article |
| id | doaj.art-ab9e458d3dad430a80a8327a49dd8dde |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-19T23:38:53Z |
| publishDate | 2021-01-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-ab9e458d3dad430a80a8327a49dd8dde2022-12-21T20:01:31ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082021-01-011119610310.34172/apb.2021.010apb-28497Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and TherapyParvaneh Bayat0Parvaneh Pakravan1Mojtaba Salouti2Jafar Ezzati Nazhad Dolatabadi3Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran.Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran.Nanobiotechnology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran.Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Purpose: Cancer is an example of the most important growing diseases in human society and scientists are trying to treat it without considerable side effects on patient’s health. Solid lipids are colloidal nanoparticles that were used in drug delivery due to their several advantages. Methods: In this work, surface modified targeted solid lipid nanoparticles (SLNs) were fabricated by nano-homogenizer using tripalmitin glyceride and stearic acid as lipid constituents. The size of nanoparticles and morphological evaluations were surveyed using particle size analyzer, scanning electron microscopy; Fourier transforms infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Results: The particle size of 148.5 and appropriate polydispersity index were achieved for lipid nanoparticles with an entrapment efficiency of 86.1%. The FT-IR analysis confirmed the coupling of lysine to the free functional group of SLNs. DSC proved the conjugation of amino acid to the surface of carriers. The in vitro epirubicin (EPI) release test exhibited the further controlled release phenomenon for the lysine conjugated nanoparticles. The cytotoxicity assay showed lower IC50 of lysine conjugated SLNs of EPI on the investigated cell line. Conclusion: These studies showed that the fabricated targeted carrier has a very remarkable anticancer effect on breast cancer cell lines in comparison with pure drug.https://apb.tbzmed.ac.ir/PDF/apb-11-96.pdfsolid lipid nanoparticlesepirubicintargeted drug deliverycytotoxicity |
| spellingShingle | Parvaneh Bayat Parvaneh Pakravan Mojtaba Salouti Jafar Ezzati Nazhad Dolatabadi Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy Advanced Pharmaceutical Bulletin solid lipid nanoparticles epirubicin targeted drug delivery cytotoxicity |
| title | Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy |
| title_full | Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy |
| title_fullStr | Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy |
| title_full_unstemmed | Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy |
| title_short | Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy |
| title_sort | lysine decorated solid lipid nanoparticles of epirubicin for cancer targeting and therapy |
| topic | solid lipid nanoparticles epirubicin targeted drug delivery cytotoxicity |
| url | https://apb.tbzmed.ac.ir/PDF/apb-11-96.pdf |
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