Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma
Introduction: Radiobiological modeling of radiotherapy plans are used for treatment plan comparisons. The current study aimed to compare the three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) plans for nasopharyngeal cancer using radiobiological mo...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-12-01
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| Series: | Iranian Journal of Medical Physics |
| Subjects: | |
| Online Access: | http://ijmp.mums.ac.ir/article_9072_6a78b3d277de37d5e8f0006583548492.pdf |
| _version_ | 1818128933288148992 |
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| author | Asghar Mesbahi Naser Rasuli Behnam Nasiri mohammad mohammadzadeh |
| author_facet | Asghar Mesbahi Naser Rasuli Behnam Nasiri mohammad mohammadzadeh |
| author_sort | Asghar Mesbahi |
| collection | DOAJ |
| description | Introduction: Radiobiological modeling of radiotherapy plans are used for treatment plan comparisons. The current study aimed to compare the three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) plans for nasopharyngeal cancer using radiobiological modeling.
Materials and Methods: This study was conducted on 10 patients with nasopharyngeal carcinoma, who were planned for 3DCRT and IMRT treatments by using the TiGRT treatment planning system. The planning target volume (PTV) doses of 70 and 72 Gy were administered for the 3DCRT and IMRT plans, respectively. The BIOLPLAN software and the Niemierko’s equivalent uniform dose (EUD) model were utilized for the estimation of tumor control probability (TCP) and normal tissue complication probability (NTCP). The NTCPs of the spinal cord, brain stem, parotid glands, middle ears, temporomandibular joints (TMJ), mandible, and thyroid were calculated by using two radiobiological models.
Results: According to the results, the mean TCPs for 3DCRT and IMRT plans were 89.92%±8.92 and 94.9%±3.86, respectively, showing no statistically significant difference (P=0.08). The NTCPs of the parotid glands, thyroid gland, spinal cord, TMJ, and mandible were considerably lower in the IMRT plans, compared to those in the 3DCRT plans. On the other hand, the calculated NTCPs for the middle ears and brain stem increased for the IMRT plans, which were not statistically significant. On average, the NTCPs of the critical organs were lower based on the EUD model than the Lyman-Kutcher-Burman model.
Conclusion: From the radiobiological point of view, the IMRT plans were significantly advantageous over the 3DCRT plans with some small variations in each patient. On average, the two radiobiological models generated different NTCPs depending on the studied organs. Consequently, more studies are needed for the optimization of radiobiological models for the prediction of the treatment outcomes in radiation therapy. |
| first_indexed | 2024-12-11T07:41:07Z |
| format | Article |
| id | doaj.art-ab9f41ba1394468f8e231071ce56dc03 |
| institution | Directory Open Access Journal |
| issn | 2345-3672 2345-3672 |
| language | English |
| last_indexed | 2024-12-11T07:41:07Z |
| publishDate | 2017-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Physics |
| spelling | doaj.art-ab9f41ba1394468f8e231071ce56dc032022-12-22T01:15:34ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2345-36722345-36722017-12-0114419019610.22038/ijmp.2017.22508.12139072Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal CarcinomaAsghar Mesbahi0Naser Rasuli1Behnam Nasiri2mohammad mohammadzadeh3Tabriz University of Medical SciencesMedical Physics department, Tabriz University of Medical SciencesRadiation Oncology Department, Imam Reza Hospital, Tabriz, IranRadiation oncology department, Tabriz university of medical sciencesIntroduction: Radiobiological modeling of radiotherapy plans are used for treatment plan comparisons. The current study aimed to compare the three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) plans for nasopharyngeal cancer using radiobiological modeling. Materials and Methods: This study was conducted on 10 patients with nasopharyngeal carcinoma, who were planned for 3DCRT and IMRT treatments by using the TiGRT treatment planning system. The planning target volume (PTV) doses of 70 and 72 Gy were administered for the 3DCRT and IMRT plans, respectively. The BIOLPLAN software and the Niemierko’s equivalent uniform dose (EUD) model were utilized for the estimation of tumor control probability (TCP) and normal tissue complication probability (NTCP). The NTCPs of the spinal cord, brain stem, parotid glands, middle ears, temporomandibular joints (TMJ), mandible, and thyroid were calculated by using two radiobiological models. Results: According to the results, the mean TCPs for 3DCRT and IMRT plans were 89.92%±8.92 and 94.9%±3.86, respectively, showing no statistically significant difference (P=0.08). The NTCPs of the parotid glands, thyroid gland, spinal cord, TMJ, and mandible were considerably lower in the IMRT plans, compared to those in the 3DCRT plans. On the other hand, the calculated NTCPs for the middle ears and brain stem increased for the IMRT plans, which were not statistically significant. On average, the NTCPs of the critical organs were lower based on the EUD model than the Lyman-Kutcher-Burman model. Conclusion: From the radiobiological point of view, the IMRT plans were significantly advantageous over the 3DCRT plans with some small variations in each patient. On average, the two radiobiological models generated different NTCPs depending on the studied organs. Consequently, more studies are needed for the optimization of radiobiological models for the prediction of the treatment outcomes in radiation therapy.http://ijmp.mums.ac.ir/article_9072_6a78b3d277de37d5e8f0006583548492.pdfNasopharyngealCancerIntensity Modulated RadiotherapyRadiobiology |
| spellingShingle | Asghar Mesbahi Naser Rasuli Behnam Nasiri mohammad mohammadzadeh Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma Iranian Journal of Medical Physics Nasopharyngeal Cancer Intensity Modulated Radiotherapy Radiobiology |
| title | Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma |
| title_full | Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma |
| title_fullStr | Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma |
| title_full_unstemmed | Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma |
| title_short | Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma |
| title_sort | radiobiological model based comparison of three dimensional conformal and intensity modulated radiation therapy plans for nasopharyngeal carcinoma |
| topic | Nasopharyngeal Cancer Intensity Modulated Radiotherapy Radiobiology |
| url | http://ijmp.mums.ac.ir/article_9072_6a78b3d277de37d5e8f0006583548492.pdf |
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