A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests
Behavioral variant frontotemporal dementia (bvFTD) is characterized by deep alterations in behavior and personality. Although revised diagnostic criteria agree for executive dysfunction as most characteristic, impairments in social cognition are also suggested. The study aimed at identifying those n...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00011/full |
| _version_ | 1811319048949989376 |
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| author | Matthias L. Schroeter Sarah Pawelke Sandrine Bisenius Jana Kynast Katharina Schuemberg Maryna Polyakova Sarah Anderl-Straub Adrian Danek Klaus Fassbender Holger Jahn Frank Jessen Johannes Kornhuber Martin Lauer Johannes Prudlo Anja Schneider Anja Schneider Ingo Uttner Angelika Thöne-Otto Markus Otto Janine Diehl-Schmid |
| author_facet | Matthias L. Schroeter Sarah Pawelke Sandrine Bisenius Jana Kynast Katharina Schuemberg Maryna Polyakova Sarah Anderl-Straub Adrian Danek Klaus Fassbender Holger Jahn Frank Jessen Johannes Kornhuber Martin Lauer Johannes Prudlo Anja Schneider Anja Schneider Ingo Uttner Angelika Thöne-Otto Markus Otto Janine Diehl-Schmid |
| author_sort | Matthias L. Schroeter |
| collection | DOAJ |
| description | Behavioral variant frontotemporal dementia (bvFTD) is characterized by deep alterations in behavior and personality. Although revised diagnostic criteria agree for executive dysfunction as most characteristic, impairments in social cognition are also suggested. The study aimed at identifying those neuropsychological and behavioral parameters best discriminating between bvFTD and healthy controls. Eighty six patients were diagnosed with possible or probable bvFTD according to Rascovsky et al. (2011) and compared with 43 healthy age-matched controls. Neuropsychological performance was assessed with a modified Reading the Mind in the Eyes Test (RMET), Stroop task, Trail Making Test (TMT), Hamasch-Five-Point Test (H5PT), and semantic and phonemic verbal fluency tasks. Behavior was assessed with the Apathy Evaluation Scale, Frontal Systems Behavioral Scale, and Bayer Activities of Daily Living Scale. Each test’s discriminatory power was investigated by Receiver Operating Characteristic curves calculating the area under the curve (AUC). bvFTD patients performed significantly worse than healthy controls in all neuropsychological tests. Discriminatory power (AUC) was highest in behavioral questionnaires, high in verbal fluency tasks and the RMET, and lower in executive function tests such as the Stroop task, TMT and H5PT. As fluency tasks depend on several cognitive functions, not only executive functions, results suggest that the RMET discriminated better between bvFTD and control subjects than other executive tests. Social cognition should be incorporated into diagnostic criteria for bvFTD in the future, such as in the International Classification of Diseases (ICD)-11, as already suggested in the Diagnostic and Statistical Manual for Mental Disorders (DSM)-5. |
| first_indexed | 2024-04-13T12:36:32Z |
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| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T12:36:32Z |
| publishDate | 2018-01-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ab9f8bbaa00c45f8930c208ddc1b7fd22022-12-22T02:46:39ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-01-011010.3389/fnagi.2018.00011294728A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function TestsMatthias L. Schroeter0Sarah Pawelke1Sandrine Bisenius2Jana Kynast3Katharina Schuemberg4Maryna Polyakova5Sarah Anderl-Straub6Adrian Danek7Klaus Fassbender8Holger Jahn9Frank Jessen10Johannes Kornhuber11Martin Lauer12Johannes Prudlo13Anja Schneider14Anja Schneider15Ingo Uttner16Angelika Thöne-Otto17Markus Otto18Janine Diehl-Schmid19Leipzig & Clinic for Cognitive Neurology, University Hospital Leipzig, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyLeipzig & Clinic for Cognitive Neurology, University Hospital Leipzig, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyLeipzig & Clinic for Cognitive Neurology, University Hospital Leipzig, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyLeipzig & Clinic for Cognitive Neurology, University Hospital Leipzig, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyLeipzig & Clinic for Cognitive Neurology, University Hospital Leipzig, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyLeipzig & Clinic for Cognitive Neurology, University Hospital Leipzig, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyDepartment of Neurology, University of Ulm, Ulm, GermanyDepartment of Neurology, Ludwig Maximilian University of Munich, Munich, GermanyDepartment of Neurology, Saarland University, Homburg, GermanyDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Psychiatry and Psychotherapy, University of Bonn, The German Center for Neurodegenerative Diseases, Bonn, GermanyDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, GermanyDepartment of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, GermanyDepartment of Neurology, University of Rostock, Rostock, GermanyDepartment of Psychiatry and Psychotherapy, University of Bonn, The German Center for Neurodegenerative Diseases, Bonn, Germany0Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, GermanyDepartment of Neurology, University of Ulm, Ulm, GermanyLeipzig & Clinic for Cognitive Neurology, University Hospital Leipzig, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyDepartment of Neurology, University of Ulm, Ulm, Germany1Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, GermanyBehavioral variant frontotemporal dementia (bvFTD) is characterized by deep alterations in behavior and personality. Although revised diagnostic criteria agree for executive dysfunction as most characteristic, impairments in social cognition are also suggested. The study aimed at identifying those neuropsychological and behavioral parameters best discriminating between bvFTD and healthy controls. Eighty six patients were diagnosed with possible or probable bvFTD according to Rascovsky et al. (2011) and compared with 43 healthy age-matched controls. Neuropsychological performance was assessed with a modified Reading the Mind in the Eyes Test (RMET), Stroop task, Trail Making Test (TMT), Hamasch-Five-Point Test (H5PT), and semantic and phonemic verbal fluency tasks. Behavior was assessed with the Apathy Evaluation Scale, Frontal Systems Behavioral Scale, and Bayer Activities of Daily Living Scale. Each test’s discriminatory power was investigated by Receiver Operating Characteristic curves calculating the area under the curve (AUC). bvFTD patients performed significantly worse than healthy controls in all neuropsychological tests. Discriminatory power (AUC) was highest in behavioral questionnaires, high in verbal fluency tasks and the RMET, and lower in executive function tests such as the Stroop task, TMT and H5PT. As fluency tasks depend on several cognitive functions, not only executive functions, results suggest that the RMET discriminated better between bvFTD and control subjects than other executive tests. Social cognition should be incorporated into diagnostic criteria for bvFTD in the future, such as in the International Classification of Diseases (ICD)-11, as already suggested in the Diagnostic and Statistical Manual for Mental Disorders (DSM)-5.http://journal.frontiersin.org/article/10.3389/fnagi.2018.00011/fullbehavioral variant frontotemporal dementiadiagnostic criteriaexecutive functionsocial cognitiontheory of mind |
| spellingShingle | Matthias L. Schroeter Sarah Pawelke Sandrine Bisenius Jana Kynast Katharina Schuemberg Maryna Polyakova Sarah Anderl-Straub Adrian Danek Klaus Fassbender Holger Jahn Frank Jessen Johannes Kornhuber Martin Lauer Johannes Prudlo Anja Schneider Anja Schneider Ingo Uttner Angelika Thöne-Otto Markus Otto Janine Diehl-Schmid A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests Frontiers in Aging Neuroscience behavioral variant frontotemporal dementia diagnostic criteria executive function social cognition theory of mind |
| title | A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests |
| title_full | A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests |
| title_fullStr | A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests |
| title_full_unstemmed | A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests |
| title_short | A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests |
| title_sort | modified reading the mind in the eyes test predicts behavioral variant frontotemporal dementia better than executive function tests |
| topic | behavioral variant frontotemporal dementia diagnostic criteria executive function social cognition theory of mind |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00011/full |
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