Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease
Background: Microcirculatory changes in congenital heart disease (CHD) patients undergoing cardiac surgery are not fully understood. We aimed to investigate the changes of retinal microcirculation in CHD patients after cardiac surgery by optical coherence tomography angiography (OCTA) and explore th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.712308/full |
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| author | Cong Li Cong Li Zhuoting Zhu Haiyun Yuan Pingting Zhong Pingting Zhong Qingsheng Peng Qingsheng Peng Xinran Dong Manqing Huang Baoyi Liu Baoyi Liu Yun Ren Yun Ren Yu Kuang Xiaomin Zeng Xiaomin Zeng Honghua Yu Xiaohong Yang |
| author_facet | Cong Li Cong Li Zhuoting Zhu Haiyun Yuan Pingting Zhong Pingting Zhong Qingsheng Peng Qingsheng Peng Xinran Dong Manqing Huang Baoyi Liu Baoyi Liu Yun Ren Yun Ren Yu Kuang Xiaomin Zeng Xiaomin Zeng Honghua Yu Xiaohong Yang |
| author_sort | Cong Li |
| collection | DOAJ |
| description | Background: Microcirculatory changes in congenital heart disease (CHD) patients undergoing cardiac surgery are not fully understood. We aimed to investigate the changes of retinal microcirculation in CHD patients after cardiac surgery by optical coherence tomography angiography (OCTA) and explore the association between retinal microcirculation and surgical outcome.Methods: This prospective observational study consisted of 71 CHD patients aged ≥6 years undergoing cardiac surgery including 19 cyanotic CHD (CCHD) and 52 acyanotic CHD (ACHD). Optical coherence tomography angiography (OCTA) was used to measure vessel density (VD) and capillary density (CD) of radial peripapillary capillary (RPC) and peripapillary, VD of superficial capillary plexus (SCP) and deep capillary plexus (DCP), thickness of retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) preoperatively and 1 month postoperatively. Transthoracic echocardiography was conducted to measure macrocirculation.Results: In CCHD patients, VD and CD of RPC and peripapillary increased postoperatively (all P < 0.05). In ACHD patients, VD of peripapillary, CD of RPC and peripapillary, and RNFL thickness increased postoperatively (all P < 0.05). VD of SCP and DCP, and GCC thickness did not change significantly in CHD patients after surgery. Lower preoperative retinal microvascular density was associated with longer cardiopulmonary bypass (CPB) time and postoperative length of stay (PLOS). No correlation was found between microcirculatory and macrohemodynamic parameters (all P > 0.05).Conclusions: Improved retinal microcirculation was observed after congenital cardiac surgery and impaired preoperative retinal microvasculature was associated with prolonged CPB time and PLOS, which might provide potential information about the outcome of congenital cardiac surgery. |
| first_indexed | 2024-12-22T01:40:33Z |
| format | Article |
| id | doaj.art-ab9fb2fa084640988becee88ed4f1b0c |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-22T01:40:33Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-ab9fb2fa084640988becee88ed4f1b0c2022-12-21T18:43:15ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-08-01810.3389/fcvm.2021.712308712308Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart DiseaseCong Li0Cong Li1Zhuoting Zhu2Haiyun Yuan3Pingting Zhong4Pingting Zhong5Qingsheng Peng6Qingsheng Peng7Xinran Dong8Manqing Huang9Baoyi Liu10Baoyi Liu11Yun Ren12Yun Ren13Yu Kuang14Xiaomin Zeng15Xiaomin Zeng16Honghua Yu17Xiaohong Yang18Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaSchool of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial Key Laboratory of South China Structural Heart Disease, Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaMedical College, Shantou University, Shantou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaMedical College, Shantou University, Shantou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaMedical College, Shantou University, Shantou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaBackground: Microcirculatory changes in congenital heart disease (CHD) patients undergoing cardiac surgery are not fully understood. We aimed to investigate the changes of retinal microcirculation in CHD patients after cardiac surgery by optical coherence tomography angiography (OCTA) and explore the association between retinal microcirculation and surgical outcome.Methods: This prospective observational study consisted of 71 CHD patients aged ≥6 years undergoing cardiac surgery including 19 cyanotic CHD (CCHD) and 52 acyanotic CHD (ACHD). Optical coherence tomography angiography (OCTA) was used to measure vessel density (VD) and capillary density (CD) of radial peripapillary capillary (RPC) and peripapillary, VD of superficial capillary plexus (SCP) and deep capillary plexus (DCP), thickness of retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) preoperatively and 1 month postoperatively. Transthoracic echocardiography was conducted to measure macrocirculation.Results: In CCHD patients, VD and CD of RPC and peripapillary increased postoperatively (all P < 0.05). In ACHD patients, VD of peripapillary, CD of RPC and peripapillary, and RNFL thickness increased postoperatively (all P < 0.05). VD of SCP and DCP, and GCC thickness did not change significantly in CHD patients after surgery. Lower preoperative retinal microvascular density was associated with longer cardiopulmonary bypass (CPB) time and postoperative length of stay (PLOS). No correlation was found between microcirculatory and macrohemodynamic parameters (all P > 0.05).Conclusions: Improved retinal microcirculation was observed after congenital cardiac surgery and impaired preoperative retinal microvasculature was associated with prolonged CPB time and PLOS, which might provide potential information about the outcome of congenital cardiac surgery.https://www.frontiersin.org/articles/10.3389/fcvm.2021.712308/fullcongenital heart diseasecardiac surgeryretinal vessel densityoptical coherence tomography angiographymicrocirculation |
| spellingShingle | Cong Li Cong Li Zhuoting Zhu Haiyun Yuan Pingting Zhong Pingting Zhong Qingsheng Peng Qingsheng Peng Xinran Dong Manqing Huang Baoyi Liu Baoyi Liu Yun Ren Yun Ren Yu Kuang Xiaomin Zeng Xiaomin Zeng Honghua Yu Xiaohong Yang Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease Frontiers in Cardiovascular Medicine congenital heart disease cardiac surgery retinal vessel density optical coherence tomography angiography microcirculation |
| title | Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease |
| title_full | Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease |
| title_fullStr | Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease |
| title_full_unstemmed | Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease |
| title_short | Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease |
| title_sort | improved retinal microcirculation after cardiac surgery in patients with congenital heart disease |
| topic | congenital heart disease cardiac surgery retinal vessel density optical coherence tomography angiography microcirculation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.712308/full |
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