Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption.
We have previously demonstrated that endothelial targeting of gold nanoparticles followed by external beam irradiation can cause specific tumor vascular disruption in mouse models of cancer. The induced vascular damage may lead to changes in tumor physiology, including tumor hypoxia, thereby comprom...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0236245 |
| _version_ | 1818678399246270464 |
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| author | Needa A Virani Olivia J Kelada Sijumon Kunjachan Alexandre Detappe Jihun Kwon Jennifer Hayashi Ana Vazquez-Pagan Douglas E Biancur Thomas Ireland Rajiv Kumar Srinivas Sridhar G Mike Makrigiorgos Ross I Berbeco |
| author_facet | Needa A Virani Olivia J Kelada Sijumon Kunjachan Alexandre Detappe Jihun Kwon Jennifer Hayashi Ana Vazquez-Pagan Douglas E Biancur Thomas Ireland Rajiv Kumar Srinivas Sridhar G Mike Makrigiorgos Ross I Berbeco |
| author_sort | Needa A Virani |
| collection | DOAJ |
| description | We have previously demonstrated that endothelial targeting of gold nanoparticles followed by external beam irradiation can cause specific tumor vascular disruption in mouse models of cancer. The induced vascular damage may lead to changes in tumor physiology, including tumor hypoxia, thereby compromising future therapeutic interventions. In this study, we investigate the dynamic changes in tumor hypoxia mediated by targeted gold nanoparticles and clinical radiation therapy (RT). By using noninvasive whole-body fluorescence imaging, tumor hypoxia was measured at baseline, on day 2 and day 13, post-tumor vascular disruption. A 2.5-fold increase (P<0.05) in tumor hypoxia was measured two days after combined therapy, resolving by day 13. In addition, the combination of vascular-targeted gold nanoparticles and radiation therapy resulted in a significant (P<0.05) suppression of tumor growth. This is the first study to demonstrate the tumor hypoxic physiological response and recovery after delivery of vascular-targeted gold nanoparticles followed by clinical radiation therapy in a human non-small cell lung cancer athymic Foxn1nu mouse model. |
| first_indexed | 2024-12-17T09:14:39Z |
| format | Article |
| id | doaj.art-aba2817600974be7babbfe7b5969fb9c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T09:14:39Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-aba2817600974be7babbfe7b5969fb9c2022-12-21T21:55:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01157e023624510.1371/journal.pone.0236245Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption.Needa A ViraniOlivia J KeladaSijumon KunjachanAlexandre DetappeJihun KwonJennifer HayashiAna Vazquez-PaganDouglas E BiancurThomas IrelandRajiv KumarSrinivas SridharG Mike MakrigiorgosRoss I BerbecoWe have previously demonstrated that endothelial targeting of gold nanoparticles followed by external beam irradiation can cause specific tumor vascular disruption in mouse models of cancer. The induced vascular damage may lead to changes in tumor physiology, including tumor hypoxia, thereby compromising future therapeutic interventions. In this study, we investigate the dynamic changes in tumor hypoxia mediated by targeted gold nanoparticles and clinical radiation therapy (RT). By using noninvasive whole-body fluorescence imaging, tumor hypoxia was measured at baseline, on day 2 and day 13, post-tumor vascular disruption. A 2.5-fold increase (P<0.05) in tumor hypoxia was measured two days after combined therapy, resolving by day 13. In addition, the combination of vascular-targeted gold nanoparticles and radiation therapy resulted in a significant (P<0.05) suppression of tumor growth. This is the first study to demonstrate the tumor hypoxic physiological response and recovery after delivery of vascular-targeted gold nanoparticles followed by clinical radiation therapy in a human non-small cell lung cancer athymic Foxn1nu mouse model.https://doi.org/10.1371/journal.pone.0236245 |
| spellingShingle | Needa A Virani Olivia J Kelada Sijumon Kunjachan Alexandre Detappe Jihun Kwon Jennifer Hayashi Ana Vazquez-Pagan Douglas E Biancur Thomas Ireland Rajiv Kumar Srinivas Sridhar G Mike Makrigiorgos Ross I Berbeco Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption. PLoS ONE |
| title | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption. |
| title_full | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption. |
| title_fullStr | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption. |
| title_full_unstemmed | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption. |
| title_short | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption. |
| title_sort | noninvasive imaging of tumor hypoxia after nanoparticle mediated tumor vascular disruption |
| url | https://doi.org/10.1371/journal.pone.0236245 |
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