Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants
C-reactive protein (CRP) has been one of the most investigated inflammatory-biomarkers during the ongoing COVID-19 pandemics caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The severe outcome among patients with SARS-CoV-2 infection is closely related to the cytokine storm an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213246/full |
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| author | Tudorita Gabriela Paranga Tudorita Gabriela Paranga Mariana Pavel-Tanasa Mariana Pavel-Tanasa Daniela Constantinescu Daniela Constantinescu Claudia Elena Plesca Claudia Elena Plesca Cristina Petrovici Cristina Petrovici Ionela-Larisa Miftode Ionela-Larisa Miftode Mihaela Moscalu Petru Cianga Petru Cianga Egidia Gabriela Miftode Egidia Gabriela Miftode |
| author_facet | Tudorita Gabriela Paranga Tudorita Gabriela Paranga Mariana Pavel-Tanasa Mariana Pavel-Tanasa Daniela Constantinescu Daniela Constantinescu Claudia Elena Plesca Claudia Elena Plesca Cristina Petrovici Cristina Petrovici Ionela-Larisa Miftode Ionela-Larisa Miftode Mihaela Moscalu Petru Cianga Petru Cianga Egidia Gabriela Miftode Egidia Gabriela Miftode |
| author_sort | Tudorita Gabriela Paranga |
| collection | DOAJ |
| description | C-reactive protein (CRP) has been one of the most investigated inflammatory-biomarkers during the ongoing COVID-19 pandemics caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The severe outcome among patients with SARS-CoV-2 infection is closely related to the cytokine storm and the hyperinflammation responsible for the acute respiratory distress syndrome and multiple organ failure. It still remains a challenge to determine which of the hyperinflammatory biomarkers and cytokines are the best predictors for disease severity and mortality in COVID-19 patients. Therefore, we evaluated and compared the outcome prediction efficiencies between CRP, the recently reported inflammatory modulators (suPAR, sTREM-1, HGF), and the classical biomarkers (MCP-1, IL-1β, IL-6, NLR, PLR, ESR, ferritin, fibrinogen, and LDH) in patients confirmed with SARS-CoV-2 infection at hospital admission. Notably, patients with severe disease had higher serum levels of CRP, suPAR, sTREM-1, HGF and classical biomarkers compared to the mild and moderate cases. Our data also identified CRP, among all investigated analytes, to best discriminate between severe and non-severe forms of disease, while LDH, sTREM-1 and HGF proved to be excellent mortality predictors in COVID-19 patients. Importantly, suPAR emerged as a key molecule in characterizing the Delta variant infections. |
| first_indexed | 2024-03-13T05:37:48Z |
| format | Article |
| id | doaj.art-aba437d689c34f0bb72a89073dc686f7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T05:37:48Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-aba437d689c34f0bb72a89073dc686f72023-06-14T05:36:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.12132461213246Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variantsTudorita Gabriela Paranga0Tudorita Gabriela Paranga1Mariana Pavel-Tanasa2Mariana Pavel-Tanasa3Daniela Constantinescu4Daniela Constantinescu5Claudia Elena Plesca6Claudia Elena Plesca7Cristina Petrovici8Cristina Petrovici9Ionela-Larisa Miftode10Ionela-Larisa Miftode11Mihaela Moscalu12Petru Cianga13Petru Cianga14Egidia Gabriela Miftode15Egidia Gabriela Miftode16Department of Infectious Diseases (Internal Medicine II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaSt. Parascheva Clinical Hospital for Infectious Diseases, Iasi, RomaniaDepartment of Immunology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaLaboratory of Immunology, St. Spiridon County Clinical Emergency Hospital, Iasi, RomaniaDepartment of Immunology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaLaboratory of Immunology, St. Spiridon County Clinical Emergency Hospital, Iasi, RomaniaDepartment of Infectious Diseases (Internal Medicine II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaSt. Parascheva Clinical Hospital for Infectious Diseases, Iasi, RomaniaDepartment of Infectious Diseases (Internal Medicine II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaSt. Parascheva Clinical Hospital for Infectious Diseases, Iasi, RomaniaDepartment of Infectious Diseases (Internal Medicine II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaSt. Parascheva Clinical Hospital for Infectious Diseases, Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaDepartment of Immunology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaLaboratory of Immunology, St. Spiridon County Clinical Emergency Hospital, Iasi, RomaniaDepartment of Infectious Diseases (Internal Medicine II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, RomaniaSt. Parascheva Clinical Hospital for Infectious Diseases, Iasi, RomaniaC-reactive protein (CRP) has been one of the most investigated inflammatory-biomarkers during the ongoing COVID-19 pandemics caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The severe outcome among patients with SARS-CoV-2 infection is closely related to the cytokine storm and the hyperinflammation responsible for the acute respiratory distress syndrome and multiple organ failure. It still remains a challenge to determine which of the hyperinflammatory biomarkers and cytokines are the best predictors for disease severity and mortality in COVID-19 patients. Therefore, we evaluated and compared the outcome prediction efficiencies between CRP, the recently reported inflammatory modulators (suPAR, sTREM-1, HGF), and the classical biomarkers (MCP-1, IL-1β, IL-6, NLR, PLR, ESR, ferritin, fibrinogen, and LDH) in patients confirmed with SARS-CoV-2 infection at hospital admission. Notably, patients with severe disease had higher serum levels of CRP, suPAR, sTREM-1, HGF and classical biomarkers compared to the mild and moderate cases. Our data also identified CRP, among all investigated analytes, to best discriminate between severe and non-severe forms of disease, while LDH, sTREM-1 and HGF proved to be excellent mortality predictors in COVID-19 patients. Importantly, suPAR emerged as a key molecule in characterizing the Delta variant infections.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213246/fullCOVID-19CRPsuPARs-TREM-1HGFbiomarkers |
| spellingShingle | Tudorita Gabriela Paranga Tudorita Gabriela Paranga Mariana Pavel-Tanasa Mariana Pavel-Tanasa Daniela Constantinescu Daniela Constantinescu Claudia Elena Plesca Claudia Elena Plesca Cristina Petrovici Cristina Petrovici Ionela-Larisa Miftode Ionela-Larisa Miftode Mihaela Moscalu Petru Cianga Petru Cianga Egidia Gabriela Miftode Egidia Gabriela Miftode Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants Frontiers in Immunology COVID-19 CRP suPAR s-TREM-1 HGF biomarkers |
| title | Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants |
| title_full | Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants |
| title_fullStr | Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants |
| title_full_unstemmed | Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants |
| title_short | Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants |
| title_sort | comparison of c reactive protein with distinct hyperinflammatory biomarkers in association with covid 19 severity mortality and sars cov 2 variants |
| topic | COVID-19 CRP suPAR s-TREM-1 HGF biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213246/full |
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