The inadequate corpus luteum
The corpus luteum is the source of progesterone in the luteal phase of the cycle and the initial two-thirds of the first trimester of pregnancy. Normal luteal function is required for fertility and the maintenance of pregnancy. Progesterone administration is increasingly used during fertility treatm...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2021-04-01
|
| Series: | Reproduction and Fertility |
| Subjects: | |
| Online Access: | https://raf.bioscientifica.com/view/journals/raf/2/1/RAF-20-0044.xml |
| _version_ | 1819146844057370624 |
|---|---|
| author | W Colin Duncan |
| author_facet | W Colin Duncan |
| author_sort | W Colin Duncan |
| collection | DOAJ |
| description | The corpus luteum is the source of progesterone in the luteal phase of the cycle and the initial two-thirds of the first trimester of pregnancy. Normal luteal function is required for fertility and the maintenance of pregnancy. Progesterone administration is increasingly used during fertility treatments and in early pregnancy to mitigate potentially inadequate corpus luteum function. This commentary considers the concept of the inadequate corpus luteum and the role and effects of exogenous progesterone. Progesterone supplementation does have important beneficial effects but we should be wary of therapeutic administration beyond or outside the evidence base. |
| first_indexed | 2024-12-22T13:20:22Z |
| format | Article |
| id | doaj.art-aba4a9caab6743929da4f0f1817224db |
| institution | Directory Open Access Journal |
| issn | 2633-8386 2633-8386 |
| language | English |
| last_indexed | 2024-12-22T13:20:22Z |
| publishDate | 2021-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Reproduction and Fertility |
| spelling | doaj.art-aba4a9caab6743929da4f0f1817224db2022-12-21T18:24:28ZengBioscientificaReproduction and Fertility2633-83862633-83862021-04-0121C1C7https://doi.org/10.1530/RAF-20-0044The inadequate corpus luteumW Colin Duncan0MRC Centre for Reproductive Health, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UKThe corpus luteum is the source of progesterone in the luteal phase of the cycle and the initial two-thirds of the first trimester of pregnancy. Normal luteal function is required for fertility and the maintenance of pregnancy. Progesterone administration is increasingly used during fertility treatments and in early pregnancy to mitigate potentially inadequate corpus luteum function. This commentary considers the concept of the inadequate corpus luteum and the role and effects of exogenous progesterone. Progesterone supplementation does have important beneficial effects but we should be wary of therapeutic administration beyond or outside the evidence base.https://raf.bioscientifica.com/view/journals/raf/2/1/RAF-20-0044.xmlluteal phase defectprogesteroneinfertilitymiscarriageluteal support |
| spellingShingle | W Colin Duncan The inadequate corpus luteum Reproduction and Fertility luteal phase defect progesterone infertility miscarriage luteal support |
| title | The inadequate corpus luteum |
| title_full | The inadequate corpus luteum |
| title_fullStr | The inadequate corpus luteum |
| title_full_unstemmed | The inadequate corpus luteum |
| title_short | The inadequate corpus luteum |
| title_sort | inadequate corpus luteum |
| topic | luteal phase defect progesterone infertility miscarriage luteal support |
| url | https://raf.bioscientifica.com/view/journals/raf/2/1/RAF-20-0044.xml |
| work_keys_str_mv | AT wcolinduncan theinadequatecorpusluteum AT wcolinduncan inadequatecorpusluteum |