Silver Nanoparticles from <em>Annona muricata</em> Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool
Cancer is one of the most prevalent diseases in the world and requires new therapies for its treatment. In this context, the biosynthesis of silver nanoparticles (AgNPs) has been developed to treat different types of tumors. The <i>Annona muricata</i> plant is known for having anticancer...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/5/1273 |
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| author | María G. González-Pedroza Liliana Argueta-Figueroa René García-Contreras Yaiza Jiménez-Martínez Eduardo Martínez-Martínez Saúl A. Navarro-Marchal Juan A. Marchal Raúl A. Morales-Luckie Houria Boulaiz |
| author_facet | María G. González-Pedroza Liliana Argueta-Figueroa René García-Contreras Yaiza Jiménez-Martínez Eduardo Martínez-Martínez Saúl A. Navarro-Marchal Juan A. Marchal Raúl A. Morales-Luckie Houria Boulaiz |
| author_sort | María G. González-Pedroza |
| collection | DOAJ |
| description | Cancer is one of the most prevalent diseases in the world and requires new therapies for its treatment. In this context, the biosynthesis of silver nanoparticles (AgNPs) has been developed to treat different types of tumors. The <i>Annona muricata</i> plant is known for having anticancer activity. Its main compounds present in the leaves, stems and skin, allowing for its use as reducing agents. In this manuscript, AgNPs with leaf extract (AgNPs-LE) and fruit peel extract (AgNPs-PE) of <i>A. muricata</i> were biosynthesized obtaining an average nanoparticle diameter sizes smaller than 50 nm, being 19.63 ± 3.7 nm and 16.56 ± 4.1 nm, and with a surface plasmonic resonance (SPR) at 447 and 448 nm, respectively. The lactone functional group present in the LE and PE extracts was identified by the FTIR technique. The behavior and antiproliferation activity of AgNPs-LE and AgNPs-PE were evaluated in breast, colon and melanoma cancer cell lines. Our results showed that <i>Annona muricata</i> fruit peel, which is a waste product, has an antitumor effect more potent than leaf extract. This difference is maintained with AgNPs where the destruction of cancer cells was, for the first time, achieved using concentrations that do not exceed 3 μg/mL with a better therapeutic index in the different tumor strains. In conclusion, we present a low-cost one-step experimental setup to generate AgNPs-PE whose in-vitro biocompatibility and powerful therapeutic effect make it a very attractive tool worth exploiting. |
| first_indexed | 2024-03-10T11:29:58Z |
| format | Article |
| id | doaj.art-aba55db41d9148609748fbf63786a76f |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T11:29:58Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-aba55db41d9148609748fbf63786a76f2023-11-21T19:23:16ZengMDPI AGNanomaterials2079-49912021-05-01115127310.3390/nano11051273Silver Nanoparticles from <em>Annona muricata</em> Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor ToolMaría G. González-Pedroza0Liliana Argueta-Figueroa1René García-Contreras2Yaiza Jiménez-Martínez3Eduardo Martínez-Martínez4Saúl A. Navarro-Marchal5Juan A. Marchal6Raúl A. Morales-Luckie7Houria Boulaiz8Department of Biotechnology, Faculty of Sciences, Autonomous University of the State of Mexico (UAEMex), Toluca 50200, MexicoConacyt Chairs, Faculty of Dentistry, Benito Juárez Autonomous University of Oaxaca, Oaxaca 68120, MexicoInterdisciplinary Research Laboratory, Nanostructures and Biomaterials, National School of Higher Studies (ENES) León Unit, National Autonomous University of Mexico (UNAM), Leon 37684, MexicoRegenerative Institute of Biopathology and Medicine (IBIMER), University of Granada, 18016 Granada, SpainLaboratory of Cell Communication and Extracellular Vesicles, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, MexicoRegenerative Institute of Biopathology and Medicine (IBIMER), University of Granada, 18016 Granada, SpainRegenerative Institute of Biopathology and Medicine (IBIMER), University of Granada, 18016 Granada, SpainJoint Center for Research in Sustainable Chemistry UAEMex—UNAM (CCIQS), Autonomous University of the State of Mexico (UAEMex), Toluca 50200, MexicoRegenerative Institute of Biopathology and Medicine (IBIMER), University of Granada, 18016 Granada, SpainCancer is one of the most prevalent diseases in the world and requires new therapies for its treatment. In this context, the biosynthesis of silver nanoparticles (AgNPs) has been developed to treat different types of tumors. The <i>Annona muricata</i> plant is known for having anticancer activity. Its main compounds present in the leaves, stems and skin, allowing for its use as reducing agents. In this manuscript, AgNPs with leaf extract (AgNPs-LE) and fruit peel extract (AgNPs-PE) of <i>A. muricata</i> were biosynthesized obtaining an average nanoparticle diameter sizes smaller than 50 nm, being 19.63 ± 3.7 nm and 16.56 ± 4.1 nm, and with a surface plasmonic resonance (SPR) at 447 and 448 nm, respectively. The lactone functional group present in the LE and PE extracts was identified by the FTIR technique. The behavior and antiproliferation activity of AgNPs-LE and AgNPs-PE were evaluated in breast, colon and melanoma cancer cell lines. Our results showed that <i>Annona muricata</i> fruit peel, which is a waste product, has an antitumor effect more potent than leaf extract. This difference is maintained with AgNPs where the destruction of cancer cells was, for the first time, achieved using concentrations that do not exceed 3 μg/mL with a better therapeutic index in the different tumor strains. In conclusion, we present a low-cost one-step experimental setup to generate AgNPs-PE whose in-vitro biocompatibility and powerful therapeutic effect make it a very attractive tool worth exploiting.https://www.mdpi.com/2079-4991/11/5/1273green synthesis of silver nanoparticles<i>Annona muricata</i> fruit peelacetogeninsantiproliferative activity |
| spellingShingle | María G. González-Pedroza Liliana Argueta-Figueroa René García-Contreras Yaiza Jiménez-Martínez Eduardo Martínez-Martínez Saúl A. Navarro-Marchal Juan A. Marchal Raúl A. Morales-Luckie Houria Boulaiz Silver Nanoparticles from <em>Annona muricata</em> Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool Nanomaterials green synthesis of silver nanoparticles <i>Annona muricata</i> fruit peel acetogenins antiproliferative activity |
| title | Silver Nanoparticles from <em>Annona muricata</em> Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool |
| title_full | Silver Nanoparticles from <em>Annona muricata</em> Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool |
| title_fullStr | Silver Nanoparticles from <em>Annona muricata</em> Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool |
| title_full_unstemmed | Silver Nanoparticles from <em>Annona muricata</em> Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool |
| title_short | Silver Nanoparticles from <em>Annona muricata</em> Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool |
| title_sort | silver nanoparticles from em annona muricata em peel and leaf extracts as a potential potent biocompatible and low cost antitumor tool |
| topic | green synthesis of silver nanoparticles <i>Annona muricata</i> fruit peel acetogenins antiproliferative activity |
| url | https://www.mdpi.com/2079-4991/11/5/1273 |
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