Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence
Introduction: Environmental microparticle is becoming a global pollutant and the entire population is increasingly exposed to the microparticles from artificial materials. The accumulation of microparticles including microplastics and its subsequent effects need to be investigated timely to keep sus...
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| Format: | Article |
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Elsevier
2023-07-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123222002065 |
| _version_ | 1797792615507165184 |
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| author | Di Wu Yudong Feng Rui Wang Jin Jiang Quanquan Guan Xu Yang Hongcheng Wei Yankai Xia Yongming Luo |
| author_facet | Di Wu Yudong Feng Rui Wang Jin Jiang Quanquan Guan Xu Yang Hongcheng Wei Yankai Xia Yongming Luo |
| author_sort | Di Wu |
| collection | DOAJ |
| description | Introduction: Environmental microparticle is becoming a global pollutant and the entire population is increasingly exposed to the microparticles from artificial materials. The accumulation of microparticles including microplastics and its subsequent effects need to be investigated timely to keep sustainable development of human society. Objectives: This study aimed to explore the accumulation of environmental particles in thrombus, the pathological structure in the blood circulation system. Methods: Patients receiving cardiovascular surgical operations were screened and twenty-six thrombi were collected, digested and filtered. Non-soluble microparticles were enriched on the filter membrane and then were analyzed and identified with Raman Spectrometer. The associations of particle status (presence or absence) or particle number in the thrombus and clinical indicators were examined. One strict quality control-particle detection system was designed to eliminate environmental contaminations. Results: Among twenty-six thrombi, sixteen contained eighty-seven identified particles ranging from 2.1 to 26.0 μm in size. The number of microparticles in each thrombus ranged from one to fifteen with the median reaching five. All the particles found in thrombi were irregularly block-shaped. Totally, twenty-one phthalocyanine particles, one Hostasol-Green particle, and one low-density polyethylene microplastic, which were from synthetic materials, were identified in thrombi. The rest microparticles included iron compounds and metallic oxides. After the adjustment for potential confounders, a significantly positive association between microparticle number and blood platelet levels was detected (P < 0.01). Conclusion: This study provides the first photograph and Raman spectrum evidence of microparticles in thrombi. A large number of non-soluble particles including synthetic material microparticles could accumulate in arteries, suggesting that the risk of microparticle exposure was under-estimated and the re-evaluation of its health effects is urgently needed. There will be a series of reports on assessing the health effects of microparticle exposure in humans in the future and this research provided clues for the subsequent research. |
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| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-03-13T02:36:33Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
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| series | Journal of Advanced Research |
| spelling | doaj.art-aba7e78a059d4b9c9f3f1246fa6426ab2023-06-29T04:14:15ZengElsevierJournal of Advanced Research2090-12322023-07-0149141150Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidenceDi Wu0Yudong Feng1Rui Wang2Jin Jiang3Quanquan Guan4Xu Yang5Hongcheng Wei6Yankai Xia7Yongming Luo8State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, ChinaChinese Academy of Sciences Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China; University of the Chinese Academy of Sciences, Beijing, 100049, ChinaDepartment of Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, ChinaState Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, ChinaState Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, ChinaState Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, ChinaState Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, ChinaState Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Corresponding authors.Chinese Academy of Sciences Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China; University of the Chinese Academy of Sciences, Beijing, 100049, China; Corresponding authors.Introduction: Environmental microparticle is becoming a global pollutant and the entire population is increasingly exposed to the microparticles from artificial materials. The accumulation of microparticles including microplastics and its subsequent effects need to be investigated timely to keep sustainable development of human society. Objectives: This study aimed to explore the accumulation of environmental particles in thrombus, the pathological structure in the blood circulation system. Methods: Patients receiving cardiovascular surgical operations were screened and twenty-six thrombi were collected, digested and filtered. Non-soluble microparticles were enriched on the filter membrane and then were analyzed and identified with Raman Spectrometer. The associations of particle status (presence or absence) or particle number in the thrombus and clinical indicators were examined. One strict quality control-particle detection system was designed to eliminate environmental contaminations. Results: Among twenty-six thrombi, sixteen contained eighty-seven identified particles ranging from 2.1 to 26.0 μm in size. The number of microparticles in each thrombus ranged from one to fifteen with the median reaching five. All the particles found in thrombi were irregularly block-shaped. Totally, twenty-one phthalocyanine particles, one Hostasol-Green particle, and one low-density polyethylene microplastic, which were from synthetic materials, were identified in thrombi. The rest microparticles included iron compounds and metallic oxides. After the adjustment for potential confounders, a significantly positive association between microparticle number and blood platelet levels was detected (P < 0.01). Conclusion: This study provides the first photograph and Raman spectrum evidence of microparticles in thrombi. A large number of non-soluble particles including synthetic material microparticles could accumulate in arteries, suggesting that the risk of microparticle exposure was under-estimated and the re-evaluation of its health effects is urgently needed. There will be a series of reports on assessing the health effects of microparticle exposure in humans in the future and this research provided clues for the subsequent research.http://www.sciencedirect.com/science/article/pii/S2090123222002065MicroparticlePigmentMicroplasticThrombusRaman Spectrometer |
| spellingShingle | Di Wu Yudong Feng Rui Wang Jin Jiang Quanquan Guan Xu Yang Hongcheng Wei Yankai Xia Yongming Luo Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence Journal of Advanced Research Microparticle Pigment Microplastic Thrombus Raman Spectrometer |
| title | Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence |
| title_full | Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence |
| title_fullStr | Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence |
| title_full_unstemmed | Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence |
| title_short | Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence |
| title_sort | pigment microparticles and microplastics found in human thrombi based on raman spectral evidence |
| topic | Microparticle Pigment Microplastic Thrombus Raman Spectrometer |
| url | http://www.sciencedirect.com/science/article/pii/S2090123222002065 |
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