Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells
Recent studies have demonstrated that the membrane potential of Purkinje cells is bi-stable and that this phenomenon underlies bi-modal simple spike firing. Membrane potential alternates between a depolarized state, that is associated with spontaneous simple spike firing (up state), and a quiescent...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2009-11-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.03.012.2009/full |
| _version_ | 1811322054951043072 |
|---|---|
| author | Dan Rokni Zohar Tal Hananel Byk Yosef Yarom |
| author_facet | Dan Rokni Zohar Tal Hananel Byk Yosef Yarom |
| author_sort | Dan Rokni |
| collection | DOAJ |
| description | Recent studies have demonstrated that the membrane potential of Purkinje cells is bi-stable and that this phenomenon underlies bi-modal simple spike firing. Membrane potential alternates between a depolarized state, that is associated with spontaneous simple spike firing (up state), and a quiescent hyperpolarized state (down state). A controversy has emerged regarding the relevance of bi-stability to the awake animal, yet recordings made from behaving cat Purkinje cells have demonstrated that at least 50% of the cells exhibit bi-modal firing. The robustness of the phenomenon in-vitro or in anaesthetized systems on the one hand, and the controversy regarding its expression in behaving animals on the other hand suggest that state transitions are under neuronal control. Indeed, we have recently demonstrated that synaptic inputs can induce transitions between the states and suggested that the role of granule cell input is to control the states of Purkinje cells rather than increase or decrease firing rate gradually. We have also shown that the state of a Purkinje cell does not only affect its firing but also the waveform of climbing fiber-driven complex spikes and the associated calcium influx. These findings call for a reconsideration of the role of Purkinje cells in cerebellar function. In this manuscript we review the recent findings on Purkinje cell bi-stability and add some analyses of its effect on the regularity and variability of Purkinje cell activity. |
| first_indexed | 2024-04-13T13:29:45Z |
| format | Article |
| id | doaj.art-aba805578659401caa1874f7274a27f1 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-13T13:29:45Z |
| publishDate | 2009-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-aba805578659401caa1874f7274a27f12022-12-22T02:45:02ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022009-11-01310.3389/neuro.03.012.2009822Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cellsDan Rokni0Zohar Tal1Hananel Byk2Yosef Yarom3Department of Neurobiology, Institute of Life Sciences, and Interdisciplinary Center for Neural Computation, Hebrew UniversityDepartment of Neurobiology, Institute of Life Sciences, and Interdisciplinary Center for Neural Computation, Hebrew UniversityDepartment of Neurobiology, Institute of Life Sciences, and Interdisciplinary Center for Neural Computation, Hebrew UniversityDepartment of Neurobiology, Institute of Life Sciences, and Interdisciplinary Center for Neural Computation, Hebrew UniversityRecent studies have demonstrated that the membrane potential of Purkinje cells is bi-stable and that this phenomenon underlies bi-modal simple spike firing. Membrane potential alternates between a depolarized state, that is associated with spontaneous simple spike firing (up state), and a quiescent hyperpolarized state (down state). A controversy has emerged regarding the relevance of bi-stability to the awake animal, yet recordings made from behaving cat Purkinje cells have demonstrated that at least 50% of the cells exhibit bi-modal firing. The robustness of the phenomenon in-vitro or in anaesthetized systems on the one hand, and the controversy regarding its expression in behaving animals on the other hand suggest that state transitions are under neuronal control. Indeed, we have recently demonstrated that synaptic inputs can induce transitions between the states and suggested that the role of granule cell input is to control the states of Purkinje cells rather than increase or decrease firing rate gradually. We have also shown that the state of a Purkinje cell does not only affect its firing but also the waveform of climbing fiber-driven complex spikes and the associated calcium influx. These findings call for a reconsideration of the role of Purkinje cells in cerebellar function. In this manuscript we review the recent findings on Purkinje cell bi-stability and add some analyses of its effect on the regularity and variability of Purkinje cell activity.http://journal.frontiersin.org/Journal/10.3389/neuro.03.012.2009/fullmossy fiberCa imagingclimbing fibercomplex spikefiring statesimple spike |
| spellingShingle | Dan Rokni Zohar Tal Hananel Byk Yosef Yarom Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells Frontiers in Cellular Neuroscience mossy fiber Ca imaging climbing fiber complex spike firing state simple spike |
| title | Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells |
| title_full | Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells |
| title_fullStr | Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells |
| title_full_unstemmed | Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells |
| title_short | Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells |
| title_sort | regularity variabilty and bi stability in the activity of cerebellar purkinje cells |
| topic | mossy fiber Ca imaging climbing fiber complex spike firing state simple spike |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.03.012.2009/full |
| work_keys_str_mv | AT danrokni regularityvariabiltyandbistabilityintheactivityofcerebellarpurkinjecells AT zohartal regularityvariabiltyandbistabilityintheactivityofcerebellarpurkinjecells AT hananelbyk regularityvariabiltyandbistabilityintheactivityofcerebellarpurkinjecells AT yosefyarom regularityvariabiltyandbistabilityintheactivityofcerebellarpurkinjecells |