Structure based design and synthesis of peptide inhibitor of human LOX-12: in vitro and in vivo analysis of a novel therapeutic agent for breast cancer.

Structure based design and synthesis of peptide inhibitor of human LOX-12: in vitro and in vivo analysis of a novel therapeutic agent for breast cancer.

Human breast cancer cell proliferation involves a complex interaction between growth factors, steroid hormones and peptide hormones. The interaction of growth factors, such as epidermal growth factor (EGF), with their receptors on breast cancer cells can lead to the hydrolysis of phospholipids and r...

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Bibliographic Details
Main Authors: Abhay Kumar Singh, Ratnakar Singh, Farhat Naz, Shyam Singh Chauhan, Amit Dinda, Abhay Anand Shukla, Kamaldeep Gill, Vaishali Kapoor, Sharmistha Dey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3285689?pdf=render

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