Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons

Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons

Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that causes motor neuron (MN) degeneration and results in patient death within a few years. To recapitulate the cytopathies of ALS patients’ MNs, <i>SOD1</i><sup>G85R</sup> mutant and corrected <i&...

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Main Authors: Hsiao-Chien Ting, Hui-I Yang, Horng-Jyh Harn, Ing-Ming Chiu, Hong-Lin Su, Xiang Li, Mei-Fang Chen, Tsung-Jung Ho, Ching-Ann Liu, Yung-Jen Tsai, Tzyy-Wen Chiou, Shinn-Zong Lin, Chia-Yu Chang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
amyotrophic lateral sclerosis (ALS)
induced pluripotent stem cell (iPSC)
motor neuron (MN)
<i>SOD1</i>
drug screening
gastrodin
Online Access:https://www.mdpi.com/2073-4409/10/10/2773

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