Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage
Abstract Background Basaloid squamous cell carcinoma of the esophagus (BSCCE) is generally detected at advanced stage and the prognosis is poorer than advanced conventional esophageal squamous cell carcinoma. Therefore, early detection is a critical to improve patients’ survival. However, only a few...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-5749-3 |
| _version_ | 1828769814618832896 |
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| author | Lianjun Di Kuang-I Fu Xinglong Wu Xuemei Liu Rui Xie Rong Zhu Biguang Tuo |
| author_facet | Lianjun Di Kuang-I Fu Xinglong Wu Xuemei Liu Rui Xie Rong Zhu Biguang Tuo |
| author_sort | Lianjun Di |
| collection | DOAJ |
| description | Abstract Background Basaloid squamous cell carcinoma of the esophagus (BSCCE) is generally detected at advanced stage and the prognosis is poorer than advanced conventional esophageal squamous cell carcinoma. Therefore, early detection is a critical to improve patients’ survival. However, only a few cases of early BSCCE have been reported and the endoscopic features of early BSCCE are not well described. We herein report the endoscopic features and associated histology of an early BSCCE limited within the mucosal lamina propria (m2). To our knowledge, this is the earliest BSCCE reported to date. Case presentation A 62-year-old male patient was admitted to our hospital because of epigastric pain for 3 months. White light endoscopy revealed a flat lesion with mild sloping at the periphery. The lesion was covered with leukoplakia, and normal vascular network could not be seen in the lesion. Magnifying endoscopy with narrow-band imaging showed abnormal intra-papillary capillary loop categorized as type B1 according to the classification of the Japan Esophageal Society. Iodine staining revealed a less-stained lesion. The lesion was completely resected through endoscopic submucosal dissection. Histopathologically, tumor cells, which were limited within the mucosal lamina propria, formed solid nests and lobule structures, with ribbon-like arrangement of sparse cytoplasm and round to ovoid hyperchromatic nuclei. A final diagnosis of early BSCCE was established. Conclusions This is the earliest BSCCE reported to date. The prominent lesion with a gentle rising slope and less-staining or abnormal stain might be initial feature of early BSCCE. |
| first_indexed | 2024-12-11T13:55:43Z |
| format | Article |
| id | doaj.art-abaf42387d0b4e6a9477e022b2463e30 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T13:55:43Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-abaf42387d0b4e6a9477e022b2463e302022-12-22T01:04:05ZengBMCBMC Cancer1471-24072019-05-011911510.1186/s12885-019-5749-3Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stageLianjun Di0Kuang-I Fu1Xinglong Wu2Xuemei Liu3Rui Xie4Rong Zhu5Biguang Tuo6Department of Gastroenterology, Affiliated Hospital, Zunyi Medical UniversityDepartment of Gastroenterology, Affiliated Hospital, Zunyi Medical UniversityDepartment of pathology, Affiliated Hospital, Zunyi Medical UniversityDepartment of Gastroenterology, Affiliated Hospital, Zunyi Medical UniversityDepartment of Gastroenterology, Affiliated Hospital, Zunyi Medical UniversityDepartment of Gastroenterology, Affiliated Hospital, Zunyi Medical UniversityDepartment of Gastroenterology, Affiliated Hospital, Zunyi Medical UniversityAbstract Background Basaloid squamous cell carcinoma of the esophagus (BSCCE) is generally detected at advanced stage and the prognosis is poorer than advanced conventional esophageal squamous cell carcinoma. Therefore, early detection is a critical to improve patients’ survival. However, only a few cases of early BSCCE have been reported and the endoscopic features of early BSCCE are not well described. We herein report the endoscopic features and associated histology of an early BSCCE limited within the mucosal lamina propria (m2). To our knowledge, this is the earliest BSCCE reported to date. Case presentation A 62-year-old male patient was admitted to our hospital because of epigastric pain for 3 months. White light endoscopy revealed a flat lesion with mild sloping at the periphery. The lesion was covered with leukoplakia, and normal vascular network could not be seen in the lesion. Magnifying endoscopy with narrow-band imaging showed abnormal intra-papillary capillary loop categorized as type B1 according to the classification of the Japan Esophageal Society. Iodine staining revealed a less-stained lesion. The lesion was completely resected through endoscopic submucosal dissection. Histopathologically, tumor cells, which were limited within the mucosal lamina propria, formed solid nests and lobule structures, with ribbon-like arrangement of sparse cytoplasm and round to ovoid hyperchromatic nuclei. A final diagnosis of early BSCCE was established. Conclusions This is the earliest BSCCE reported to date. The prominent lesion with a gentle rising slope and less-staining or abnormal stain might be initial feature of early BSCCE.http://link.springer.com/article/10.1186/s12885-019-5749-3Basaloid squamous cell carcinomaEarly diagnosisEndoscopic featureEsophagus |
| spellingShingle | Lianjun Di Kuang-I Fu Xinglong Wu Xuemei Liu Rui Xie Rong Zhu Biguang Tuo Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage BMC Cancer Basaloid squamous cell carcinoma Early diagnosis Endoscopic feature Esophagus |
| title | Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage |
| title_full | Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage |
| title_fullStr | Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage |
| title_full_unstemmed | Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage |
| title_short | Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage |
| title_sort | endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage |
| topic | Basaloid squamous cell carcinoma Early diagnosis Endoscopic feature Esophagus |
| url | http://link.springer.com/article/10.1186/s12885-019-5749-3 |
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