Non-Coding RNAs in Hepatocellular Carcinoma
Liver cancer ranks as the fourth leading cause of cancer-related deaths. Despite extensive research efforts aiming to evaluate the biological mechanisms underlying hepatocellular carcinoma (HCC) development, little has been translated towards new diagnostic and treatment options for HCC patients. Hi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Livers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4389/2/3/17 |
| _version_ | 1827659458604433408 |
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| author | Mascha Korsch Alexander Margetts Claes Wahlestedt Ines Lohse |
| author_facet | Mascha Korsch Alexander Margetts Claes Wahlestedt Ines Lohse |
| author_sort | Mascha Korsch |
| collection | DOAJ |
| description | Liver cancer ranks as the fourth leading cause of cancer-related deaths. Despite extensive research efforts aiming to evaluate the biological mechanisms underlying hepatocellular carcinoma (HCC) development, little has been translated towards new diagnostic and treatment options for HCC patients. Historically, the focus has been centered on coding RNAs and their respective proteins. However, significant advances in sequencing and RNA detection technologies have shifted the research focus towards non-coding RNAs (ncRNA), as well as their impact on HCC development and progression. A number of studies reported complex post-transcriptional interactions between various ncRNA and coding RNA molecules. These interactions offer insights into the role of ncRNAs in both the known pathways leading to oncogenesis, such as dysregulation of p53, and lesser-known mechanisms, such as small nucleolar RNA methylation. Studies investigating these mechanisms have identified prevalent ncRNA changes in microRNAs, snoRNAs, and long non-coding RNAs that can both pre- and post-translationally regulate key factors in HCC progression. In this review, we present relevant publications describing ncRNAs to summarize the impact of different ncRNA species on liver cancer development and progression and to evaluate recent attempts at clinical translation. |
| first_indexed | 2024-03-09T23:22:44Z |
| format | Article |
| id | doaj.art-abb02cd31e664265af44bac12262760a |
| institution | Directory Open Access Journal |
| issn | 2673-4389 |
| language | English |
| last_indexed | 2024-03-09T23:22:44Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Livers |
| spelling | doaj.art-abb02cd31e664265af44bac12262760a2023-11-23T17:24:38ZengMDPI AGLivers2673-43892022-09-012318521310.3390/livers2030017Non-Coding RNAs in Hepatocellular CarcinomaMascha Korsch0Alexander Margetts1Claes Wahlestedt2Ines Lohse3Center for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL 33136, USACenter for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL 33136, USACenter for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL 33136, USACenter for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL 33136, USALiver cancer ranks as the fourth leading cause of cancer-related deaths. Despite extensive research efforts aiming to evaluate the biological mechanisms underlying hepatocellular carcinoma (HCC) development, little has been translated towards new diagnostic and treatment options for HCC patients. Historically, the focus has been centered on coding RNAs and their respective proteins. However, significant advances in sequencing and RNA detection technologies have shifted the research focus towards non-coding RNAs (ncRNA), as well as their impact on HCC development and progression. A number of studies reported complex post-transcriptional interactions between various ncRNA and coding RNA molecules. These interactions offer insights into the role of ncRNAs in both the known pathways leading to oncogenesis, such as dysregulation of p53, and lesser-known mechanisms, such as small nucleolar RNA methylation. Studies investigating these mechanisms have identified prevalent ncRNA changes in microRNAs, snoRNAs, and long non-coding RNAs that can both pre- and post-translationally regulate key factors in HCC progression. In this review, we present relevant publications describing ncRNAs to summarize the impact of different ncRNA species on liver cancer development and progression and to evaluate recent attempts at clinical translation.https://www.mdpi.com/2673-4389/2/3/17non-coding RNAsliver cancersnoRNAlncRNAhepatocellular carcinomamicroRNA |
| spellingShingle | Mascha Korsch Alexander Margetts Claes Wahlestedt Ines Lohse Non-Coding RNAs in Hepatocellular Carcinoma Livers non-coding RNAs liver cancer snoRNA lncRNA hepatocellular carcinoma microRNA |
| title | Non-Coding RNAs in Hepatocellular Carcinoma |
| title_full | Non-Coding RNAs in Hepatocellular Carcinoma |
| title_fullStr | Non-Coding RNAs in Hepatocellular Carcinoma |
| title_full_unstemmed | Non-Coding RNAs in Hepatocellular Carcinoma |
| title_short | Non-Coding RNAs in Hepatocellular Carcinoma |
| title_sort | non coding rnas in hepatocellular carcinoma |
| topic | non-coding RNAs liver cancer snoRNA lncRNA hepatocellular carcinoma microRNA |
| url | https://www.mdpi.com/2673-4389/2/3/17 |
| work_keys_str_mv | AT maschakorsch noncodingrnasinhepatocellularcarcinoma AT alexandermargetts noncodingrnasinhepatocellularcarcinoma AT claeswahlestedt noncodingrnasinhepatocellularcarcinoma AT ineslohse noncodingrnasinhepatocellularcarcinoma |