Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra
Seven undescribed cembranoids, sacraoxides A–G (1, 3–8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher’s method and X-ray diffraction crystallography. Compounds...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-03-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.649287/full |
| _version_ | 1818727511716003840 |
|---|---|
| author | Bingyang Zhang Di Liu Wenyue Ji Kouharu Otsuki Koji Higai Feng Zhao Wei Li Kazuo Koike Feng Qiu |
| author_facet | Bingyang Zhang Di Liu Wenyue Ji Kouharu Otsuki Koji Higai Feng Zhao Wei Li Kazuo Koike Feng Qiu |
| author_sort | Bingyang Zhang |
| collection | DOAJ |
| description | Seven undescribed cembranoids, sacraoxides A–G (1, 3–8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher’s method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 and 36.4 ± 2.9 μM. |
| first_indexed | 2024-12-17T22:15:16Z |
| format | Article |
| id | doaj.art-abb1bd3ce5184448929b145ee8a28491 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-17T22:15:16Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-abb1bd3ce5184448929b145ee8a284912022-12-21T21:30:38ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-03-01910.3389/fchem.2021.649287649287Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacraBingyang Zhang0Di Liu1Wenyue Ji2Kouharu Otsuki3Koji Higai4Feng Zhao5Wei Li6Kazuo Koike7Feng Qiu8School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaFaculty of Pharmaceutical Sciences, Toho University, Tokyo, JapanFaculty of Pharmaceutical Sciences, Toho University, Tokyo, JapanSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, ChinaFaculty of Pharmaceutical Sciences, Toho University, Tokyo, JapanFaculty of Pharmaceutical Sciences, Toho University, Tokyo, JapanSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSeven undescribed cembranoids, sacraoxides A–G (1, 3–8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher’s method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 and 36.4 ± 2.9 μM.https://www.frontiersin.org/articles/10.3389/fchem.2021.649287/fullBoswellia sacraolibanumphytochemistrycembranoidsstructure elucidationanti-inflammatory |
| spellingShingle | Bingyang Zhang Di Liu Wenyue Ji Kouharu Otsuki Koji Higai Feng Zhao Wei Li Kazuo Koike Feng Qiu Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra Frontiers in Chemistry Boswellia sacra olibanum phytochemistry cembranoids structure elucidation anti-inflammatory |
| title | Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra |
| title_full | Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra |
| title_fullStr | Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra |
| title_full_unstemmed | Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra |
| title_short | Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra |
| title_sort | sacraoxides a g bioactive cembranoids from gum resin of boswellia sacra |
| topic | Boswellia sacra olibanum phytochemistry cembranoids structure elucidation anti-inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.649287/full |
| work_keys_str_mv | AT bingyangzhang sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra AT diliu sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra AT wenyueji sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra AT kouharuotsuki sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra AT kojihigai sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra AT fengzhao sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra AT weili sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra AT kazuokoike sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra AT fengqiu sacraoxidesagbioactivecembranoidsfromgumresinofboswelliasacra |