MicroRNAs in meningiomas: Potential biomarkers and therapeutic targets
Meningiomas, characterized primarily as benign intracranial or spinal tumors, present distinctive challenges due to their variable clinical behavior, with certain cases exhibiting aggressive features linked to elevated morbidity and mortality. Despite their prevalence, the underlying molecular mecha...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-09-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024000325 |
| _version_ | 1797234060053970944 |
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| author | Ozal Beylerli Tatiana Ilyasova Huaizhang Shi Albert Sufianov |
| author_facet | Ozal Beylerli Tatiana Ilyasova Huaizhang Shi Albert Sufianov |
| author_sort | Ozal Beylerli |
| collection | DOAJ |
| description | Meningiomas, characterized primarily as benign intracranial or spinal tumors, present distinctive challenges due to their variable clinical behavior, with certain cases exhibiting aggressive features linked to elevated morbidity and mortality. Despite their prevalence, the underlying molecular mechanisms governing the initiation and progression of meningiomas remain insufficiently understood. MicroRNAs (miRNAs), small endogenous non-coding RNAs orchestrating post-transcriptional gene expression, have garnered substantial attention in this context. They emerge as pivotal biomarkers and potential therapeutic targets, offering innovative avenues for managing meningiomas. Recent research delves into the intricate mechanisms by which miRNAs contribute to meningioma pathogenesis, unraveling the molecular complexities of this enigmatic tumor. Meningiomas, originating from arachnoid meningothelial cells and known for their gradual growth, constitute a significant portion of intracranial tumors. The clinical challenge lies in comprehending their progression, particularly factors associated with brain invasion and heightened recurrence rates, which remain elusive. This comprehensive review underscores the pivotal role of miRNAs, accentuating their potential to advance our comprehension of meningioma biology. Furthermore, it suggests promising directions for developing diagnostic biomarkers and therapeutic interventions, holding the promise of markedly improved patient outcomes in the face of this intricate and variable disease. |
| first_indexed | 2024-04-24T16:26:03Z |
| format | Article |
| id | doaj.art-abb1c3838f204baf89e795a21abea4e4 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T16:26:03Z |
| publishDate | 2024-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-abb1c3838f204baf89e795a21abea4e42024-03-31T04:37:50ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-09-0193641648MicroRNAs in meningiomas: Potential biomarkers and therapeutic targetsOzal Beylerli0Tatiana Ilyasova1Huaizhang Shi2Albert Sufianov3Central Research Laboratory, Bashkir State Medical University, Republic of Bashkortostan, 3 Lenin Street, Ufa, 450008, Russia; Corresponding author.Department of Internal Diseases, Bashkir State Medical University, Republic of Bashkortostan 450008, Ufa, RussiaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaEducational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaMeningiomas, characterized primarily as benign intracranial or spinal tumors, present distinctive challenges due to their variable clinical behavior, with certain cases exhibiting aggressive features linked to elevated morbidity and mortality. Despite their prevalence, the underlying molecular mechanisms governing the initiation and progression of meningiomas remain insufficiently understood. MicroRNAs (miRNAs), small endogenous non-coding RNAs orchestrating post-transcriptional gene expression, have garnered substantial attention in this context. They emerge as pivotal biomarkers and potential therapeutic targets, offering innovative avenues for managing meningiomas. Recent research delves into the intricate mechanisms by which miRNAs contribute to meningioma pathogenesis, unraveling the molecular complexities of this enigmatic tumor. Meningiomas, originating from arachnoid meningothelial cells and known for their gradual growth, constitute a significant portion of intracranial tumors. The clinical challenge lies in comprehending their progression, particularly factors associated with brain invasion and heightened recurrence rates, which remain elusive. This comprehensive review underscores the pivotal role of miRNAs, accentuating their potential to advance our comprehension of meningioma biology. Furthermore, it suggests promising directions for developing diagnostic biomarkers and therapeutic interventions, holding the promise of markedly improved patient outcomes in the face of this intricate and variable disease.http://www.sciencedirect.com/science/article/pii/S2468054024000325MeningiomasMicroRNAsBiomarkersTherapeutic targetsTumorigenesisIntracranial tumors |
| spellingShingle | Ozal Beylerli Tatiana Ilyasova Huaizhang Shi Albert Sufianov MicroRNAs in meningiomas: Potential biomarkers and therapeutic targets Non-coding RNA Research Meningiomas MicroRNAs Biomarkers Therapeutic targets Tumorigenesis Intracranial tumors |
| title | MicroRNAs in meningiomas: Potential biomarkers and therapeutic targets |
| title_full | MicroRNAs in meningiomas: Potential biomarkers and therapeutic targets |
| title_fullStr | MicroRNAs in meningiomas: Potential biomarkers and therapeutic targets |
| title_full_unstemmed | MicroRNAs in meningiomas: Potential biomarkers and therapeutic targets |
| title_short | MicroRNAs in meningiomas: Potential biomarkers and therapeutic targets |
| title_sort | micrornas in meningiomas potential biomarkers and therapeutic targets |
| topic | Meningiomas MicroRNAs Biomarkers Therapeutic targets Tumorigenesis Intracranial tumors |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024000325 |
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