Nitric oxide products are not associated with metabolic syndrome
Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current stud...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2019-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581903361A.pdf |
| _version_ | 1818607635999490048 |
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| author | Klisić Aleksandra Kocić Gordana Kavarić Nebojša Pavlović Radmila Soldatović Ivan Ninić Ana |
| author_facet | Klisić Aleksandra Kocić Gordana Kavarić Nebojša Pavlović Radmila Soldatović Ivan Ninić Ana |
| author_sort | Klisić Aleksandra |
| collection | DOAJ |
| description | Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO ) xanthine dehydrogenase (XD H)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002 -1.019; p=0.016 ), XO (OR=1.014 ; 95% CI 1.003 -1.026 ; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 μmol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD , MDA and AOPP NOx is not associated with MetS. |
| first_indexed | 2024-12-16T14:29:54Z |
| format | Article |
| id | doaj.art-abb2a1b9b4f346c183fb10eeb50e47a1 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-16T14:29:54Z |
| publishDate | 2019-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-abb2a1b9b4f346c183fb10eeb50e47a12022-12-21T22:28:16ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662019-01-013833613671452-82581903361ANitric oxide products are not associated with metabolic syndromeKlisić Aleksandra0Kocić Gordana1Kavarić Nebojša2Pavlović Radmila3Soldatović Ivan4https://orcid.org/0000-0003-4893-1683Ninić Ana5https://orcid.org/0000-0003-3838-1606University of Montenegro, Faculty of Medicine, Primary Health Care Center, Podgorica, MontenegroUniversity of Niš, School of Medicine, Department of Medical BiochemistryUniversity of Montenegro, Faculty of Medicine, Primary Health Care Center, Podgorica, MontenegroUniversity of Milan, Department of Health, Animal Science and Food Safety, Milan, ItalyUniversity of Belgrade, Faculty of Medicine, Institute for Biostatistics, Medical informatics and researches in MedicineUniversity of Belgrade, Faculty of Pharmacy, Department of Medical BiochemistryBackground: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO ) xanthine dehydrogenase (XD H)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002 -1.019; p=0.016 ), XO (OR=1.014 ; 95% CI 1.003 -1.026 ; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 μmol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD , MDA and AOPP NOx is not associated with MetS.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581903361A.pdfinflammationmetabolic syndromeobesityoxidative stress |
| spellingShingle | Klisić Aleksandra Kocić Gordana Kavarić Nebojša Pavlović Radmila Soldatović Ivan Ninić Ana Nitric oxide products are not associated with metabolic syndrome Journal of Medical Biochemistry inflammation metabolic syndrome obesity oxidative stress |
| title | Nitric oxide products are not associated with metabolic syndrome |
| title_full | Nitric oxide products are not associated with metabolic syndrome |
| title_fullStr | Nitric oxide products are not associated with metabolic syndrome |
| title_full_unstemmed | Nitric oxide products are not associated with metabolic syndrome |
| title_short | Nitric oxide products are not associated with metabolic syndrome |
| title_sort | nitric oxide products are not associated with metabolic syndrome |
| topic | inflammation metabolic syndrome obesity oxidative stress |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581903361A.pdf |
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