Hair product use, age at menarche and mammographic breast density in multiethnic urban women
Abstract Background Select hair products contain endocrine disrupting chemicals (EDCs) that may affect breast cancer risk. We hypothesize that, if EDCs are related to breast cancer risk, then they may also affect two important breast cancer risk factors: age at menarche and mammographic breast densi...
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Environmental Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12940-017-0345-y |
| _version_ | 1818619557865062400 |
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| author | Jasmine A. McDonald Parisa Tehranifar Julie D. Flom Mary Beth Terry Tamarra James-Todd |
| author_facet | Jasmine A. McDonald Parisa Tehranifar Julie D. Flom Mary Beth Terry Tamarra James-Todd |
| author_sort | Jasmine A. McDonald |
| collection | DOAJ |
| description | Abstract Background Select hair products contain endocrine disrupting chemicals (EDCs) that may affect breast cancer risk. We hypothesize that, if EDCs are related to breast cancer risk, then they may also affect two important breast cancer risk factors: age at menarche and mammographic breast density. Methods In two urban female cohorts (N = 248): 1) the New York site of the National Collaborative Perinatal Project and 2) the New York City Multiethnic Breast Cancer Project, we measured childhood and adult use of hair oils, lotions, leave-in conditioners, root stimulators, perms/relaxers, and hair dyes using the same validated questionnaire. We used multivariable relative risk regression models to examine the association between childhood hair product use and early age at menarche (defined as <11 years of age) and multivariable linear regression models to examine the association between childhood and adult hair product use and adult mammographic breast density. Results Early menarche was associated with ever use of childhood hair products (RR 2.3, 95% CI 1.1, 4.8) and hair oil use (RR 2.5, 95% CI 1.2, 5.2); however, additional adjustment for race/ethnicity, attenuated associations (hair products RR 1.8, 95% CI 0.8, 4.1; hair oil use RR 2.3, 95% CI 1.0, 5.5). Breast density was not associated with adult or childhood hair product or hair oil use. Conclusions If confirmed in larger prospective studies, these data suggest that exposure to EDCs through hair products in early life may affect breast cancer risk by altering timing of menarche, and may operate through a mechanism distinct from breast density. |
| first_indexed | 2024-12-16T17:39:23Z |
| format | Article |
| id | doaj.art-abb3d18efaba4718b313175eeacd67ce |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-16T17:39:23Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-abb3d18efaba4718b313175eeacd67ce2022-12-21T22:22:39ZengBMCEnvironmental Health1476-069X2018-01-011711810.1186/s12940-017-0345-yHair product use, age at menarche and mammographic breast density in multiethnic urban womenJasmine A. McDonald0Parisa Tehranifar1Julie D. Flom2Mary Beth Terry3Tamarra James-Todd4Department of Epidemiology, Mailman School of Public Health, Columbia University Medical CenterDepartment of Epidemiology, Mailman School of Public Health, Columbia University Medical CenterDepartment of Epidemiology, Mailman School of Public Health, Columbia University Medical CenterDepartment of Epidemiology, Mailman School of Public Health, Columbia University Medical CenterDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public HealthAbstract Background Select hair products contain endocrine disrupting chemicals (EDCs) that may affect breast cancer risk. We hypothesize that, if EDCs are related to breast cancer risk, then they may also affect two important breast cancer risk factors: age at menarche and mammographic breast density. Methods In two urban female cohorts (N = 248): 1) the New York site of the National Collaborative Perinatal Project and 2) the New York City Multiethnic Breast Cancer Project, we measured childhood and adult use of hair oils, lotions, leave-in conditioners, root stimulators, perms/relaxers, and hair dyes using the same validated questionnaire. We used multivariable relative risk regression models to examine the association between childhood hair product use and early age at menarche (defined as <11 years of age) and multivariable linear regression models to examine the association between childhood and adult hair product use and adult mammographic breast density. Results Early menarche was associated with ever use of childhood hair products (RR 2.3, 95% CI 1.1, 4.8) and hair oil use (RR 2.5, 95% CI 1.2, 5.2); however, additional adjustment for race/ethnicity, attenuated associations (hair products RR 1.8, 95% CI 0.8, 4.1; hair oil use RR 2.3, 95% CI 1.0, 5.5). Breast density was not associated with adult or childhood hair product or hair oil use. Conclusions If confirmed in larger prospective studies, these data suggest that exposure to EDCs through hair products in early life may affect breast cancer risk by altering timing of menarche, and may operate through a mechanism distinct from breast density.http://link.springer.com/article/10.1186/s12940-017-0345-yMenarcheMammographic breast densityEndocrine disrupting chemicalsCosmetics |
| spellingShingle | Jasmine A. McDonald Parisa Tehranifar Julie D. Flom Mary Beth Terry Tamarra James-Todd Hair product use, age at menarche and mammographic breast density in multiethnic urban women Environmental Health Menarche Mammographic breast density Endocrine disrupting chemicals Cosmetics |
| title | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
| title_full | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
| title_fullStr | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
| title_full_unstemmed | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
| title_short | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
| title_sort | hair product use age at menarche and mammographic breast density in multiethnic urban women |
| topic | Menarche Mammographic breast density Endocrine disrupting chemicals Cosmetics |
| url | http://link.springer.com/article/10.1186/s12940-017-0345-y |
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