Iris atrophy after administration of Dexycu: Additional evidence and possible mechanism for a rare complication

Purpose: To report the observation of iris atrophy with the use of Dexycu in cataract surgery and describe a possible mechanism for this complication. Observations: Between 2020 and 2021, 2 patients underwent cataract surgery procedures with the use of Dexycu and experienced iris atrophy. The first...

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Main Authors: Azraa Ayesha, Ryan T. Wallace, Anthony P. Mai, Rachel G. Simpson, Craig J. Chaya
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:American Journal of Ophthalmology Case Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2451993623000142
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author Azraa Ayesha
Ryan T. Wallace
Anthony P. Mai
Rachel G. Simpson
Craig J. Chaya
author_facet Azraa Ayesha
Ryan T. Wallace
Anthony P. Mai
Rachel G. Simpson
Craig J. Chaya
author_sort Azraa Ayesha
collection DOAJ
description Purpose: To report the observation of iris atrophy with the use of Dexycu in cataract surgery and describe a possible mechanism for this complication. Observations: Between 2020 and 2021, 2 patients underwent cataract surgery procedures with the use of Dexycu and experienced iris atrophy. The first case of iris atrophy was discovered by 6-month follow-up and the second case by 2-month follow-up. The timing and nature of this complication possibly represent more than steroid-induced hypopigmentation. Conclusions and Importance: This publication adds further evidence of iris atrophy and a proposed mechanism associated with the use of Dexycu. Surgeons should be aware of this complication, especially when operating on eyes with dark irides.
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spelling doaj.art-abb59cd3982d4fc2b1928674696fe2702023-05-19T04:46:07ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362023-06-0130101806Iris atrophy after administration of Dexycu: Additional evidence and possible mechanism for a rare complicationAzraa Ayesha0Ryan T. Wallace1Anthony P. Mai2Rachel G. Simpson3Craig J. Chaya4University of Utah School of Medicine, USABaylor College of Medicine Department of Ophthalmology, USAUniversity of Utah Department of Ophthalmology, John A. Moran Eye Center, USAUniversity of Utah Department of Ophthalmology, John A. Moran Eye Center, USAUniversity of Utah Department of Ophthalmology, John A. Moran Eye Center, USA; Corresponding author. University of Utah Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, 65 Mario Capecchi Drive, Salt Lake City, UT, 84132, USA.Purpose: To report the observation of iris atrophy with the use of Dexycu in cataract surgery and describe a possible mechanism for this complication. Observations: Between 2020 and 2021, 2 patients underwent cataract surgery procedures with the use of Dexycu and experienced iris atrophy. The first case of iris atrophy was discovered by 6-month follow-up and the second case by 2-month follow-up. The timing and nature of this complication possibly represent more than steroid-induced hypopigmentation. Conclusions and Importance: This publication adds further evidence of iris atrophy and a proposed mechanism associated with the use of Dexycu. Surgeons should be aware of this complication, especially when operating on eyes with dark irides.http://www.sciencedirect.com/science/article/pii/S2451993623000142DexycuCataractSteroidIrisAtrophySurgery
spellingShingle Azraa Ayesha
Ryan T. Wallace
Anthony P. Mai
Rachel G. Simpson
Craig J. Chaya
Iris atrophy after administration of Dexycu: Additional evidence and possible mechanism for a rare complication
American Journal of Ophthalmology Case Reports
Dexycu
Cataract
Steroid
Iris
Atrophy
Surgery
title Iris atrophy after administration of Dexycu: Additional evidence and possible mechanism for a rare complication
title_full Iris atrophy after administration of Dexycu: Additional evidence and possible mechanism for a rare complication
title_fullStr Iris atrophy after administration of Dexycu: Additional evidence and possible mechanism for a rare complication
title_full_unstemmed Iris atrophy after administration of Dexycu: Additional evidence and possible mechanism for a rare complication
title_short Iris atrophy after administration of Dexycu: Additional evidence and possible mechanism for a rare complication
title_sort iris atrophy after administration of dexycu additional evidence and possible mechanism for a rare complication
topic Dexycu
Cataract
Steroid
Iris
Atrophy
Surgery
url http://www.sciencedirect.com/science/article/pii/S2451993623000142
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AT anthonypmai irisatrophyafteradministrationofdexycuadditionalevidenceandpossiblemechanismforararecomplication
AT rachelgsimpson irisatrophyafteradministrationofdexycuadditionalevidenceandpossiblemechanismforararecomplication
AT craigjchaya irisatrophyafteradministrationofdexycuadditionalevidenceandpossiblemechanismforararecomplication